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JCI early table of contents for March 25, 2013
Date:3/25/2013

View this article at: http://www.jci.org/articles/view/65220?key=e01448d06d00a554dcf9

ACCOMPANYING COMMENTARY

TITLE:
Desmoglein 1, Differentiation, and Disease

AUTHOR CONTACT:
John R. Stanley
Dept. Of Dermatology, Philadelphia, PA, USA
Phone: 215/898-3240; Fax: 215-573-2033; E-mail: jrstan@mail.med.upenn.edu

View this article at: http://www.jci.org/articles/view/69071?key=64cb3a0ec3a2a8bbeb4f

Researchers optimize embryonic stem cell-derived retinal progenitors for transplant

Tissues derived from embryonic stem cells (ESCs) could potentially be used to replace cells and tissues in patients with degenerative diseases, but they could also cause serious side effects - ESCs and ESC-derived progenitor cells have previously been shown to spontaneously form tumors. In this issue of the Journal of Clinical Investigation, researchers led by Ying Jin at the Institute of Health Sciences in Shanghai, identified a cellular signaling pathway that controls tumorigenicity in ESC-derived retinal progenitor cells. Retinal degeneration is a leading cause of blindness that could potentially be treated by replacement of the defective retinal cells. Jin and colleagues found that the WNT signaling cascade was a critical determinant of both the tumorigenicity and therapeutic function of ESC-derived retinal progenitors. By inhibiting WNT signaling, they could improve the function of retinal progenitors in mice while preventing tumor formation. In a companion commentary, Kang Zhang and colleagues the University of California, San Diego, discuss how these findings could broadly apply to the development of new stem cell therapies.

TITLE:
WNT signaling determines tumorigenicity and funct
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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