Navigation Links
JCI early table of contents for March 25, 2013
Date:3/25/2013

View this article at: http://www.jci.org/articles/view/65220?key=e01448d06d00a554dcf9

ACCOMPANYING COMMENTARY

TITLE:
Desmoglein 1, Differentiation, and Disease

AUTHOR CONTACT:
John R. Stanley
Dept. Of Dermatology, Philadelphia, PA, USA
Phone: 215/898-3240; Fax: 215-573-2033; E-mail: jrstan@mail.med.upenn.edu

View this article at: http://www.jci.org/articles/view/69071?key=64cb3a0ec3a2a8bbeb4f

Researchers optimize embryonic stem cell-derived retinal progenitors for transplant

Tissues derived from embryonic stem cells (ESCs) could potentially be used to replace cells and tissues in patients with degenerative diseases, but they could also cause serious side effects - ESCs and ESC-derived progenitor cells have previously been shown to spontaneously form tumors. In this issue of the Journal of Clinical Investigation, researchers led by Ying Jin at the Institute of Health Sciences in Shanghai, identified a cellular signaling pathway that controls tumorigenicity in ESC-derived retinal progenitor cells. Retinal degeneration is a leading cause of blindness that could potentially be treated by replacement of the defective retinal cells. Jin and colleagues found that the WNT signaling cascade was a critical determinant of both the tumorigenicity and therapeutic function of ESC-derived retinal progenitors. By inhibiting WNT signaling, they could improve the function of retinal progenitors in mice while preventing tumor formation. In a companion commentary, Kang Zhang and colleagues the University of California, San Diego, discuss how these findings could broadly apply to the development of new stem cell therapies.

TITLE:
WNT signaling determines tumorigenicity and funct
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Netsmart Clients to Receive Nearly $2 Million in Meaningful Use EHR Incentive Payments
2. Access BridgeGap Ventures to Focus on Early-Stage Therapeutic Opportunities
3. VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer
4. Sequenom Announces 2011 Operational Highlights and Early 2012 Outlook
5. CSL Behring Study Confirms Early Treatment with Berinert® Provides Faster Resolution of Acute Hereditary Angioedema Symptoms
6. Corporate Venturing and Early-Stage Financing in the Spotlight at BioTrinity
7. Butamax Early Adopters Group surpasses capacity targets with addition of Big River; Membership represents 11 production facilities and nearly 900 million gallons of ethanol capacity
8. Researchers peek at the early evolution of sex chromosomes
9. Discuss Early Results of the DIAN Trial at CBIs 6th Annual Alzheimers Drug Development Summit
10. Early career distinction: Prestigious award recognizes physicists work in electron dynamics
11. JCI early table of contents for Sept. 4, 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... ... detection and quantification of partially hydrolyzed gluten in foods, has been accepted by ... the method “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” ...
(Date:7/30/2015)... ... 30, 2015 , ... The 2015 Market Research Report on the Global ... the global Propanol market with a focus on the Chinese situation. Major companies included ... Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , ...
(Date:7/30/2015)... across the globe, ISN improves the efficiency and effectiveness of contractor management systems. ISN,s ... reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Headquartered in Dallas, TX , ISN has additional offices in Calgary ...
(Date:7/30/2015)... ... July 30, 2015 , ... GEA's Pony™ NS2006L ... operation up to 1500 bar. The sanitary design gauge of the NS2006L is ... , The Pony™ NS2006L homogenizer is an ideal solution for the processing of ...
Breaking Biology Technology:RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2
... Jan. 12 The Risk Management and Patient,Safety ... 2009 audio,program calendar. The RM&PSI ( http://www.rmpsi.com ... ), is a national leader in,clinical risk management ... health care institutions. , ...
... The French agency Agence de Medecine,Preventive (AMP) announced ... Director for the SIVAC (Supporting Independent Immunization and,Vaccine ... to,the development of national immunization technical advisory groups ... in Asia. These committees will help,national health authorities ...
... PARK, Ill., Jan. 12 Abbott today is,announcing ... previously issued 2008 earnings-per-share guidance of $3.31 to ... expects earnings per share,of $3.65 to $3.70 under ... basis. The midpoint of this 2009 guidance ...
Cached Biology Technology:The Risk Management and Patient Safety Institute Announces Winter and Spring 2009 Audio Program Lineup, Annual Conference Dates 2The Risk Management and Patient Safety Institute Announces Winter and Spring 2009 Audio Program Lineup, Annual Conference Dates 3French Agency AMP Appoints Dr Kamel Senouci as Director of SIVAC Initiative (Supporting Independent Immunization and Vaccine Advisory Committees) 2French Agency AMP Appoints Dr Kamel Senouci as Director of SIVAC Initiative (Supporting Independent Immunization and Vaccine Advisory Committees) 3Abbott Announces Earnings Guidance for 2009 2
(Date:7/21/2015)... July 21, 2015  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... announces that it has filed provisional patent 62/192218 ... This invention highlights next generation ... an account, but also the user using unique ...
(Date:7/13/2015)... OXFORD, Conn. , Jul. 13, 2015 /PRNewswire/ ... the "Company"), a biometric authentication company focused on ... it has filed provisional patent 62/188684 for ... NXT-ID achieves another new convenient and secure method ... expands new, innovative payment methods, introduced with its ...
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new Match-in-Sensor™ ... hardware encapsulated fingerprint sensor and matching solution. ... literally off the grid, isolating fingerprint image ... the fingerprint sensor to provide ultimate protection ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3
... pregnant women have twice the risk of preterm delivery ... to a new study by the Kaiser Permanente Division ... Oxford University Press,s journal Human Reproduction on ... Embryology. The study found that pregnant women with ...
... RIVERSIDE, Calif. The leading cause of death in all ... to chemotherapy, a form of treatment in which chemicals are ... UC Riverside biochemists that focuses on cancer cells reports that ... vegetables and fruit improves cancer cells, response to chemotherapy. ...
... The Marine Mammal Center is seeing a large number of ... a study to determine when and why the sea lions contract ... a surge in the number of sea lions admitted as a ... be lethal for patients. The current research will focus on ...
Cached Biology News:Depression during pregnancy can double risk of preterm delivery 2How eating fruit and vegetables can improve cancer patients' response to chemotherapy 2The Marine Mammal Center begins new leptospirosis study in California 2
... Features, Special optically clear polystyrene formulation ... performance in immunoassay applications , Plates ... lower coefficients of variation , Eight-well ... elimi-nating strip loss while in use even ...
...
... Easy-Titer Human IgM Assay Kit to address ... easy-to-perform assay for Human IgM that eliminates ... incorporates a simple mix-and-read assay that allows ... 15-500 ng/ml in approximately 30 minutes. The ...
... clarification reagent; Ideal for clarifying many ... proteins, nucleic acids, & proteoglycans; Contains ... improves downstream processing; Utilizes a reagent ... supplied as a suspension in saline; ...
Biology Products: