Navigation Links
JCI early table of contents for March 25, 2013
Date:3/25/2013

Exploring the cause of sudden unexplained death in epilepsy

Dravet syndrome (DS) is a form of infantile-onset, treatment-resistant epilepsy that is caused by a mutation in the gene encoding a voltage-gated sodium channel, SCN1A. DS patients have a 30-fold increased risk of dying from sudden unexplained death in epilepsy (SUDEP) compared to patients with other forms of pediatric-onset epilepsy. In this issue of the Journal of Clinical Investigation, Franck Kalume and colleagues at the University of Washington characterized SUDEP in a mouse model of DS. Observation using video, electroencephalography, and electrocardiography revealed that a prolonged slowing of the heart beat preceded SUDEP in mice. Treatment with with drugs that reduce activity in the parasympathetic nervous system reduced the incidence of SUDEP, suggesting that mortality results from seizure-related parasympathetic hyperactivity. In a companion Attending Physician, Orrin Devinsky and colleagues discuss how these results could relate to SUDEP in human DS patients.

TITLE:
Sudden unexpected death in a mouse model of Dravet Syndrome

AUTHOR CONTACT:
William Catterall
University of Washington, Seattle, WA, USA
Phone: (206) 543-1970; Fax: (206) 685-3822; E-mail: wcatt@uw.edu

View this article at: http://www.jci.org/articles/view/66220?key=bc7ca495798f6f01e8cf

ACCOMPANYING THE ATTENDING PHYSICIAN

TITLE:
Sudden death in epilepsy: Of mice and men

AUTHOR CONTACT:
Orrin Devinsky
New York University Langone Medical Center
Phone: 646-558-0803; E-mail: od4@nyu.edu

View this article at: http://www.jci.org/articles/view/67759?key=77e9caf46a8bc6b89166

Lymphatic
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Netsmart Clients to Receive Nearly $2 Million in Meaningful Use EHR Incentive Payments
2. Access BridgeGap Ventures to Focus on Early-Stage Therapeutic Opportunities
3. VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer
4. Sequenom Announces 2011 Operational Highlights and Early 2012 Outlook
5. CSL Behring Study Confirms Early Treatment with Berinert® Provides Faster Resolution of Acute Hereditary Angioedema Symptoms
6. Corporate Venturing and Early-Stage Financing in the Spotlight at BioTrinity
7. Butamax Early Adopters Group surpasses capacity targets with addition of Big River; Membership represents 11 production facilities and nearly 900 million gallons of ethanol capacity
8. Researchers peek at the early evolution of sex chromosomes
9. Discuss Early Results of the DIAN Trial at CBIs 6th Annual Alzheimers Drug Development Summit
10. Early career distinction: Prestigious award recognizes physicists work in electron dynamics
11. JCI early table of contents for Sept. 4, 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... (PRWEB) September 23, 2014 Cambridge Semantics, ... Semantic Web technology, was named in the recent ‘Hype ... Inc. , The report details key insights pertaining ... , According to Gartner analysts Michael Shanler and Stephen ... innovation activities, expose complex relationships with scientific stakeholders, and ...
(Date:9/23/2014)... WASHINGTON, New York , September 23, 2014 ... ), a leading provider of  Closed System Transfer   ... a new exclusive partnership with Taiwanese distributor MedFront Medical Technology ... regulatory bodies in Taiwan , ... for approval as the company continues to expand ...
(Date:9/23/2014)... Latham, NY (PRWEB) September 23, 2014 ... line of deep ultra violet emitters in the 280 ... of standard UV emitters which range from 280nm to ... air and water sanitation as well as curing. Mark ... product line of special interest to manufacturers is that ...
(Date:9/23/2014)... York (PRWEB) September 23, 2014 ... around the globe will convene at the ... Conference, to be held October 26-28 in ... evidence-based research and practice in individualized integrative ... scientists, researchers, nurses, psychologists, nutritionists, naturopaths, acupuncturists, ...
Breaking Biology Technology:Cambridge Semantics Identified in Gartner’s ‘Hype Cycle for Life Sciences 2014’ Report 2Equashield Enters Taiwan Following Expansion to Australia, Japan, China 2Marktech Introduces its New Line of Deep UV Emitters 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 3
... Celsion Corporation (Nasdaq: CLSN ), an oncology ... of innovative oncology drugs, today announced that it has ... select group of institutional investors, including certain officers and ... 8% redeemable convertible preferred stock with a stated value ...
... massive death of brain cells after a stroke, the explosion in ... as autism, schizophrenia and mental retardation show no physical signs of ... brain cells communicate with one another. To understand ... activity is key. But even the best imaging devices available ...
... success of the previous conferences of the series held ... (EPD) conferences are a leading venue for experts from ... as a processing technique for fabrication of both traditional ... electric surface charge on particles in suspension, which migrate ...
Cached Biology Technology:Celsion Corporation Announces Convertible Preferred Stock Financing and Amended License Agreement for Aggregate Gross Proceeds of up to $9 Million 2Celsion Corporation Announces Convertible Preferred Stock Financing and Amended License Agreement for Aggregate Gross Proceeds of up to $9 Million 3Celsion Corporation Announces Convertible Preferred Stock Financing and Amended License Agreement for Aggregate Gross Proceeds of up to $9 Million 4New UCLA-designed microscope records firing of thousands of individual neurons in 3-D 2New UCLA-designed microscope records firing of thousands of individual neurons in 3-D 34th International Conference on Electrophoretic Deposition 24th International Conference on Electrophoretic Deposition 34th International Conference on Electrophoretic Deposition 4
(Date:9/22/2014)... be much more useful in homes, if they could ... the world with cameras and lasers, which have difficulty ... hidden in clutter. A complementary way robots can "sense" ... small ultra-high frequency radio-frequency identification (UHF RFID) tags. Inexpensive ... RFID-equipped robot to search a room for the correct ...
(Date:9/22/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD ), a ... market, issues the following corporate shareholder update following the ... Letter from the CEO : ... joined the NASDAQ to support ramping of production of ... authentication products and services. This strategic achievement positions NXT-ID to ...
(Date:9/21/2014)... cowpea (black-eyed peas) is a fascinating example of how ... is the story of the scientist behind the research. ... of the 21st Century to serve as an accessible ... was recently published by the Crop Science Society of ... (IITA). , Singh has devoted his life,s work to ...
Breaking Biology News(10 mins):New RFID technology helps robots find household objects 2New RFID technology helps robots find household objects 3NXT-ID Issues Shareholder Corporate Update 2NXT-ID Issues Shareholder Corporate Update 3NXT-ID Issues Shareholder Corporate Update 4
... examine the safety and preliminary effectiveness of two ... opened to volunteer enrollment. The trial, sponsored by ... (NIAID), part of the National Institutes of Health, ... Africa and the United States. , Although no ...
... "Because up to 75 percent of breast cancer,patients ... pathway,drugs that target different molecules along that pathway ... a researcher from,The University of Texas M. D. ... now emerging,about the importance of the phosphatidylinositol 3 ...
... PANTHER, a protein classification system from,Applied Biosystems, got ... molecular and biological function (GO ontology) and known,pathways. ... it incorporate,automated GO surrepresentation analysis with graphical output. ... paper describing the Database is available freely ...
Cached Biology News: MetaChip provides quick, efficient toxicity screening of potential drugs 2PANTHER Protein Classification System Database 5.0 2PANTHER Protein Classification System Database 5.0 3
... V is a fully integrated system for ... processing that deliver excellent quality microarray images. ... quality microarray scanner that is based on ... background rejection and spatial resolution. The DNAscope ...
Ca2+ Channel Ca gamma 2 Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 50 µl Consult technical datasheet for details....
Rabbit polyclonal antibody to NCOA2 [Agarose Immobilized]...
Monocarboxylate (lactate) transporter 2...
Biology Products: