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JCI early table of contents for Aug. 8, 2013
Date:8/9/2013

Engineered rice protects against rotavirus

For children and immune compromised adults in developing countries, diarrheal disease induced by rotavirus can be life threatening. Current rotaviral vaccines are highly effective in the Western world, but are not as effective in developing countries. Additionally, these vaccines are not appropriate for use outside of a very narrow age window or in immune compromised individuals. In the current issue of the Journal of Clinical Investigation Yoshikazu Yuki and colleagues at the University of Tokyo report the development of a strain of rice that produces a rotavirus-specific antibody. Both normal and immune deficient mice fed the engineered rice were protected against rotavirus. The researchers also report that the rice maintains its efficacy even after long-term storage and heat exposure. This study provides a low cost, efficient strategy for prevention of rotavirus infection.

TITLE: Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection

AUTHOR CONTACT: Daisuke Tokuhara
The Institute of Medical Science, The University of Tokyo, Tokyo, UNK, JPN
Phone: 81-3-5449-5271; Fax: 81-3-5449-5411; E-mail: tokuhara@ims.u-tokyo.ac.jp

View this article at: http://www.jci.org/articles/view/70266?key=de80321a713532149b56


Tumor microenvironment allows cancer cells to hide from the immune system

Cancer progression is aided by the ability of tumors to evade recognition by the immune system. In this issue of the Journal of Clinical Investigation, Gerard Blobe and colleagues at Duke University identify a mechanism by which tumors evade detection. Using mouse models of breast cancer and melanoma, they show that loss of the Type III TGF-β
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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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