Navigation Links
JCI early table of contents for Aug. 8, 2013
Date:8/9/2013

Engineered rice protects against rotavirus

For children and immune compromised adults in developing countries, diarrheal disease induced by rotavirus can be life threatening. Current rotaviral vaccines are highly effective in the Western world, but are not as effective in developing countries. Additionally, these vaccines are not appropriate for use outside of a very narrow age window or in immune compromised individuals. In the current issue of the Journal of Clinical Investigation Yoshikazu Yuki and colleagues at the University of Tokyo report the development of a strain of rice that produces a rotavirus-specific antibody. Both normal and immune deficient mice fed the engineered rice were protected against rotavirus. The researchers also report that the rice maintains its efficacy even after long-term storage and heat exposure. This study provides a low cost, efficient strategy for prevention of rotavirus infection.

TITLE: Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection

AUTHOR CONTACT: Daisuke Tokuhara
The Institute of Medical Science, The University of Tokyo, Tokyo, UNK, JPN
Phone: 81-3-5449-5271; Fax: 81-3-5449-5411; E-mail: tokuhara@ims.u-tokyo.ac.jp

View this article at: http://www.jci.org/articles/view/70266?key=de80321a713532149b56


Tumor microenvironment allows cancer cells to hide from the immune system

Cancer progression is aided by the ability of tumors to evade recognition by the immune system. In this issue of the Journal of Clinical Investigation, Gerard Blobe and colleagues at Duke University identify a mechanism by which tumors evade detection. Using mouse models of breast cancer and melanoma, they show that loss of the Type III TGF-β receptor (TGFBR3) in tumors promotes cancer progression by altering signaling in tumor-associated immune cells. This study supports the use of TGF-β inhibitors to enhance the efficacy of therapies that promote immune-mediated elimination of tumor cells.

TITLE: Type III TGF-β receptor downregulation generates and immunotolerant tumor microenvironment

AUTHOR CONTACT: Gerard C. Blobe
Duke University, Durham, NC, USA
Phone: (919) 668-1352; Fax: (919) 681-6906; E-mail: blobe001@mc.duke.edu

View this article at: http://www.jci.org/articles/view/65745?key=f673123b974c4089ed3b


ALSO IN THIS ISSUE

TITLE: Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity

AUTHOR CONTACT: Hongzhen Hu
University of Texas Health Science at Houston, Houston, TX, USA
Phone: 713-500-7525; E-mail: Hongzhen.Hu@uth.tmc.edu

View this article at: http://www.jci.org/articles/view/66413?key=07980efc5faef311fc46

TITLE: Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B

AUTHOR CONTACT: Jody Baron
University of California, San Francisco, San Francsico, CA, USA
Phone: 415 476 5728; Fax: 415 476 0659; E-mail: jody.baron@ucsf.edu

View this article at: http://www.jci.org/articles/view/68182?key=4813eaa63d2ce5b8fb76

TITLE: Increased Fanconi C expression contributes to the emergency granulopoiesis response

AUTHOR CONTACT: Elizabeth Eklund
Northwestern University and Jesse Brown VHA Medical Center, Chicago, IL, USA
Phone: 312 503 3207; Fax: 312 908 5717; E-mail: e-eklund@northwestern.edu

View this article at: http://www.jci.org/articles/view/69032?key=1ae6052432e2d7e84f1e

TITLE: Nanoparticle-based flow virometry for the analysis of individual virions

AUTHOR CONTACT: Jean-Charles Grivel
Eunice Kennedy Shriver National Institute of Child Health & Human Development, Bethesda, MD, USA
Phone: 301 496 1298; Fax: 301 480 0857; E-mail: mailto:grivelj@mail.nih.gov

View this article at: http://www.jci.org/articles/view/67042?key=a318cc3a6f46bf3f4469


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related biology technology :

1. Pearly Whites Laser Dentistry Launches Ground Breaking Cavity Prevention Program that Can Lower Decay Rates by 74%
2. RiboMed and Austrian Institute of Technology Partner on Epigenetic Tests for Early Lung Cancer Detection, Sub-typing and Drug Response
3. Surveyed Physicians Indicate that Xtandi is Prescribed to Nearly One Quarter of Metastatic Castrate-Resistant Prostate Cancer Patients Who Have Failed to Respond to Prior Docetaxel Treatment
4. Adult cells transformed into early-stage nerve cells, bypassing the pluripotent stem cell stage
5. Early Stage Drug Delivery Technologies: 62 Profiles of Start-ups and Emerging Companies
6. Finally, the need of nearly every woman wanting to look more beautiful is fulfilled with Crisalix, the first online direct-to-consumer 3D imaging using standard pictures
7. Bed Bugs Get Family Throwing Nearly All Their Possessions, My Cleaning Offers Help With Complimentary Samples of Non-Pesticide Bed Bug Bully
8. Elsevier Launches Web-Based Pathway Studio and Adds New Molecular Data from Its Biology Journals to Boost Early Discovery Research
9. JCI early table of contents for March 25, 2013
10. The Elsevier Foundation, TWAS, and OWSD Honor Early Career Women Scientists in Developing Countries at the Annual AAAS Meeting
11. Patheon to Host Complimentary Seminar on “Getting Your Drug through Phase I Early Development Effectively” at Milton Park, UK Facility
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... PA (PRWEB) , ... August 16, 2017 , ... While ... they are much more closely connected than one might think. A Mesh Is ... will open at the University City Science Center’s Esther Klein Gallery (EKG) on August ...
(Date:8/15/2017)... -- After spending the past two years building a state-of-the-art technology ... now offers this platform to healthcare stakeholders (hospitals, foundations, biopharma companies ... data collection vis a vis their members, under their own brand. ... this offer. ... ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kenall, a leader in sealed ... stay tightly sealed and perform efficiently for years. The downlights are ideal for ... aren't enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food and ...
(Date:8/14/2017)... ... August 14, 2017 , ... ... device-to-computer interconnect using USB or PCI Express, announced the release of SYZYGY™, a ... intended to satisfy the need for a compact, low cost, low pin-count, high-performance ...
Breaking Biology Technology:
(Date:3/30/2017)... The research team of The Hong Kong Polytechnic University (PolyU) ... ground breaking 3D fingerprint minutiae recovery and matching technology, pushing contactless ... use in identification, crime investigation, immigration control, security of access and ... ... A research team led by Dr Ajay Kumar ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access ... 15.1% over the next decade to reach approximately $1,580 million by ... and forecasts for all the given segments on global as well ...
Breaking Biology News(10 mins):