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JCI early table of contents for Aug. 15, 2013
Date:8/16/2013

e current issue of the Journal of Clinical Investigation, Michael Holtzman and colleagues at the Washington University School of Medicine report that expression of an inflammatory molecule, interleukin-33 (IL-33), is increased in the airways of both a mouse model of viral-induced COPD and humans with COPD. Increased IL-33 was associated with an increase in mucus production, and expression of other COPD-implicated genes. The authors found in their mouse model that expression of the gene encoding IL-33 was localized to a population of lungs cells that were induced in the airway after viral infection. These results lay the groundwork for potential therapeutic strategies aimed at preventing COPD after acute lung infection.

TITLE: Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease

AUTHOR CONTACT: Michael Holtzman
Washington University School of Medicine, St. Louis, MO, USA
Phone: 314-362-8970; Fax: 314-362-9002; E-mail: holtzmanm@wustl.edu

View this article at: http://www.jci.org/articles/view/65570?key=ae7cd696212eb8d494a6


ALSO IN THIS ISSUE

TITLE: Intestinal Epithelial Vitamin D Receptor Signaling Inhibits Experimental Colitis

AUTHOR CONTACT: Yan Chun Li
The University of Chicago, Chicago, IL, USA
Phone: 773-702-2477; Fax: 773-702-2281; E-mail: cyan@medicine.bsd.uchicago.edu

View this article at: http://www.jci.org/articles/view/65842?key=2b9d5961301e6f81b988

TITLE: Fanconi anemia signaling network regulates the spindle assembly checkpoint

AUTHOR CONTACT: D. Wade Clapp
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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3

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