Navigation Links
JCI early table of contents for Aug. 15, 2013
Date:8/16/2013

Biomarkers predict time to ovarian cancer recurrence

Ovarian cancer often remains undetected until it is at an advanced stage. Despite positive responses to initial treatment, many patients are at risk of tumor recurrence. A multitude of genetic markers have been implicated in ovarian cancer prognosis. However, the genetic testing required is not practical or affordable in a clinical setting. In this issue of the Journal of Clinical Investigation, Roel Verchaak and colleagues at the MD Anderson Cancer Center identify protein biomarkers that are predictive for time of ovarian cancer recurrence and develop a PRotein-driven index of OVARian cancer (PROVAR). Using PROVAR, the authors were able to discriminate between patients with high and low risk of cancer recurrence, as well as short-term and long-term survival prognosis. In combination with genetic diagnosis, analysis of protein biomarkers may be useful in predicting outcome and determining a treatment plan for ovarian cancer patients.

TITLE: Predicting Time to Ovarian Carcinoma Recurrence Using Protein Markers

AUTHOR CONTACT: Roel G.W. Verhaak
MD Anderson Cancer Center, Houston, TX, USA
Phone: 7135632293; E-mail: RVerhaak@mdanderson.org

View this article at: http://www.jci.org/articles/view/68509?key=d03afe0843e018bcf8a0


A molecule involved in development of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is characterized by poor airflow due to the breakdown of lung tissue, mucus accumulation and airway dysfunction. Development of COPD is most commonly associated with smoking tobacco, however, it also occurs after acute respiratory infections such as influenza. It is unclear how prior lung disease leads to COPD. In the current issue of the Journal of Clinical Investigation, Michael Holtzman and colleagues at the Washington University School of Medicine report that expression of an inflammatory molecule, interleukin-33 (IL-33), is increased in the airways of both a mouse model of viral-induced COPD and humans with COPD. Increased IL-33 was associated with an increase in mucus production, and expression of other COPD-implicated genes. The authors found in their mouse model that expression of the gene encoding IL-33 was localized to a population of lungs cells that were induced in the airway after viral infection. These results lay the groundwork for potential therapeutic strategies aimed at preventing COPD after acute lung infection.

TITLE: Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease

AUTHOR CONTACT: Michael Holtzman
Washington University School of Medicine, St. Louis, MO, USA
Phone: 314-362-8970; Fax: 314-362-9002; E-mail: holtzmanm@wustl.edu

View this article at: http://www.jci.org/articles/view/65570?key=ae7cd696212eb8d494a6


ALSO IN THIS ISSUE

TITLE: Intestinal Epithelial Vitamin D Receptor Signaling Inhibits Experimental Colitis

AUTHOR CONTACT: Yan Chun Li
The University of Chicago, Chicago, IL, USA
Phone: 773-702-2477; Fax: 773-702-2281; E-mail: cyan@medicine.bsd.uchicago.edu

View this article at: http://www.jci.org/articles/view/65842?key=2b9d5961301e6f81b988

TITLE: Fanconi anemia signaling network regulates the spindle assembly checkpoint

AUTHOR CONTACT: D. Wade Clapp
Indiana University, Indianapolis, IN, USA
Phone: 317-278-9290; Fax: 317-274-8679; E-mail: dclapp@iupui.edu

View this article at: http://www.jci.org/articles/view/67364?key=6dc2a2297a9ddb1dd3b7

TITLE: Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts

AUTHOR CONTACT: Jae-Hyuck Shim
Weill Cornell Medical College, New York, NY, USA
Phone: 212-746-2078; Fax: 212-746-9215; E-mail: jas2060@med.cornell.edu

View this article at: http://www.jci.org/articles/view/69443?key=820d4b38e367f804b885

TITLE: Differentiation and functional regulation of human fetal NK cells

AUTHOR CONTACT: Jakob Michaelsson
Karolinska Institutet, Stockholm, UNK, SWE
Phone: +46 763142535; E-mail: jakob.michaelsson@ki.se

View this article at: http://www.jci.org/articles/view/68989?key=e247bd20642c062caca9

TITLE: Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy

AUTHOR CONTACT: Leisa Johnson
Genentech, Inc., South San Francisco, CA, USA
Phone: 650-467-7381; Fax: 650-225-6412; E-mail: leisaj@gene.com

View this article at: http://www.jci.org/articles/view/67892?key=e94d797612ede6a94c5c


'/>"/>

Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related biology technology :

1. Netsmart Clients to Receive Nearly $2 Million in Meaningful Use EHR Incentive Payments
2. Access BridgeGap Ventures to Focus on Early-Stage Therapeutic Opportunities
3. VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer
4. Sequenom Announces 2011 Operational Highlights and Early 2012 Outlook
5. CSL Behring Study Confirms Early Treatment with Berinert® Provides Faster Resolution of Acute Hereditary Angioedema Symptoms
6. Corporate Venturing and Early-Stage Financing in the Spotlight at BioTrinity
7. Butamax Early Adopters Group surpasses capacity targets with addition of Big River; Membership represents 11 production facilities and nearly 900 million gallons of ethanol capacity
8. Researchers peek at the early evolution of sex chromosomes
9. Discuss Early Results of the DIAN Trial at CBIs 6th Annual Alzheimers Drug Development Summit
10. Early career distinction: Prestigious award recognizes physicists work in electron dynamics
11. JCI early table of contents for Sept. 4, 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/10/2017)... , ... October 10, 2017 , ... San Diego-based team ... its corporate rebranding initiative announced today. The bold new look is part of ... the company moves into a significant growth period. , It will also expand its ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and ... San Diego Rotary Club. The event entitled “Stem Cells and Their ... 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter ...
(Date:10/10/2017)... ... 10, 2017 , ... USDM Life Sciences , the ... sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer Jaye ... GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to achieving ...
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... The award-winning ... to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... is faced with the challenge of how to continue to feed a growing nation. ...
Breaking Biology Technology:
(Date:4/4/2017)... --  EyeLock LLC , a leader of iris-based identity ... and Trademark Office (USPTO) has issued U.S. Patent No. ... iris image with a face image acquired in sequence ... th issued patent. "The issuance ... multi-modal biometric capabilities that have recently come to market ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/24/2017)... Controller General of Immigration from Maldives Mr. Mohamed Anwar and ... international IAIR Award for the most innovative high security ePassport and eGates  ... ... Maldives Immigration Controller General, Mr. Mohamed Anwar ... right) have received the IAIR award for the "Most innovative high security ...
Breaking Biology News(10 mins):