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JCI early table of contents for Aug. 15, 2013

Biomarkers predict time to ovarian cancer recurrence

Ovarian cancer often remains undetected until it is at an advanced stage. Despite positive responses to initial treatment, many patients are at risk of tumor recurrence. A multitude of genetic markers have been implicated in ovarian cancer prognosis. However, the genetic testing required is not practical or affordable in a clinical setting. In this issue of the Journal of Clinical Investigation, Roel Verchaak and colleagues at the MD Anderson Cancer Center identify protein biomarkers that are predictive for time of ovarian cancer recurrence and develop a PRotein-driven index of OVARian cancer (PROVAR). Using PROVAR, the authors were able to discriminate between patients with high and low risk of cancer recurrence, as well as short-term and long-term survival prognosis. In combination with genetic diagnosis, analysis of protein biomarkers may be useful in predicting outcome and determining a treatment plan for ovarian cancer patients.

TITLE: Predicting Time to Ovarian Carcinoma Recurrence Using Protein Markers

MD Anderson Cancer Center, Houston, TX, USA
Phone: 7135632293; E-mail:

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A molecule involved in development of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is characterized by poor airflow due to the breakdown of lung tissue, mucus accumulation and airway dysfunction. Development of COPD is most commonly associated with smoking tobacco, however, it also occurs after acute respiratory infections such as influenza. It is unclear how prior lung disease leads to COPD. In the current issue of the Journal of Clinical Investigation, Michael Holtzman and colleagues at the Washington University School of Medicine report that expression of an inflammatory molecule, interleukin-33 (IL-33), is increased in the airways of both a mouse model of viral-induced COPD and humans with COPD. Increased IL-33 was associated with an increase in mucus production, and expression of other COPD-implicated genes. The authors found in their mouse model that expression of the gene encoding IL-33 was localized to a population of lungs cells that were induced in the airway after viral infection. These results lay the groundwork for potential therapeutic strategies aimed at preventing COPD after acute lung infection.

TITLE: Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease

AUTHOR CONTACT: Michael Holtzman
Washington University School of Medicine, St. Louis, MO, USA
Phone: 314-362-8970; Fax: 314-362-9002; E-mail:

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TITLE: Intestinal Epithelial Vitamin D Receptor Signaling Inhibits Experimental Colitis

The University of Chicago, Chicago, IL, USA
Phone: 773-702-2477; Fax: 773-702-2281; E-mail:

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TITLE: Fanconi anemia signaling network regulates the spindle assembly checkpoint

Indiana University, Indianapolis, IN, USA
Phone: 317-278-9290; Fax: 317-274-8679; E-mail:

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TITLE: Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts

Weill Cornell Medical College, New York, NY, USA
Phone: 212-746-2078; Fax: 212-746-9215; E-mail:

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TITLE: Differentiation and functional regulation of human fetal NK cells

AUTHOR CONTACT: Jakob Michaelsson
Karolinska Institutet, Stockholm, UNK, SWE
Phone: +46 763142535; E-mail:

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TITLE: Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy

Genentech, Inc., South San Francisco, CA, USA
Phone: 650-467-7381; Fax: 650-225-6412; E-mail:

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Contact: Corinne Williams
Journal of Clinical Investigation

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