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IsoTis Files Definitive Proxy Statement
Date:9/5/2007

/A>. Documents filed with the SEC by IsoTis are also available free of charge on the investor relations portion of the IsoTis website at http://www.IsoTis.com. The proxy statement was first mailed to stockholders on or about September 5, 2007.

Participants in the Solicitation

IsoTis, and its directors and executive officers may be deemed to be participants in the solicitation of proxies from IsoTis' stockholders in connection with the proposed merger with Integra. The names of IsoTis' directors and executive officers and a description of their interests in IsoTis are set forth in IsoTis S.A.'s Annual Report on Form 20-F, which was filed with the SEC on May 11, 2007. Investors and stockholders can obtain more detailed information regarding the direct and indirect interests of IsoTis' directors and executive officers in the merger by reading the definitive proxy statement.


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