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Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting
Date:4/20/2009

DENVER and CARLSBAD, Calif., April 20 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that Isis and its collaborators presented results on antisense inhibition of novel targets that could offer new mechanisms to treat cancer during the American Association for Cancer Research (AACR) meeting. Research conducted by Isis and its collaborators demonstrated the feasibility of targeting a large non-coding RNA, sigma RNA also known as Malat-1, that could offer a new therapeutic mechanism to treat disease. Isis also presented new preclinical data showing that antisense inhibition of STAT5 resulted in potent anti-tumor activity. The oral presentations were presented today, April 20, at the AACR 100th Annual Meeting 2009 in Denver, Colorado by Isis and its collaborators.

The presentation by R. Lin from The Scripps Research Institute on work done in collaboration with scientists from Isis and titled "Molecular Control of RNA Alternative Splicing by sigma RNA, a Marker for Carcinomas" showed that antisense inhibition of Malat-1 altered the splicing of multiple mRNAs. Altering splicing results in the production of different variations of a protein, including variations that could be associated with cancer. Malat-1 is up-regulated in many human cancers including liver, breast, lung, pancreas, colon, and prostate.

Isis scientist Y. Kim presented research titled "Selective Inhibition of STAT5 Expression in Acute Myeloid Leukemia Cells Results in Potent Antitumor Activity" showing that antisense inhibition of STAT5 increased survival in preclinical models of acute myeloid leukemia (AML) suggesting that antisense drugs targeting STAT5 may offer a new avenue to treat AML and related blood disorders.

"The work presented at this year's AACR demonstrates the broad applicability of
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SOURCE Isis Pharmaceuticals, Inc.
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