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Investigational Studies Highlight Potential Utility of Zevalin(R) (Ibritumomab Tiuxetan) Radioimmunotherapy in Stem Cell Transplantation for Non-Hodgkin's Lymphoma
Date:6/1/2008

pport. The maximum tolerated dose (MTD) was not reached in the study. These data indicate that the dose of (90)Yttrium used with the Zevalin regimen can be escalated provided there is a stem cell rescue.

(90)Yttrium Ibritumomab Tiuxetan Combined with High-dose BEAM Chemotherapy and Autologous Stem Cell Transplantation for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma, Abstract 8615

The goal of this phase II trial was to evaluate the safety and efficacy of combining RIT with high-dose carmustine, cytarabine, etoposide, and melphalan (BEAM) chemotherapy and ASCT in patients with relapsed or refractory NHL. With a median follow up of 11 months, results from the first ten patients showed adverse events were similar to those seen with high-dose BEAM alone. The authors concluded that these preliminary results suggest that the combination of RIT and BEAM followed by ASCT is does not add significantly to the toxicity of BEAM alone and the combination is effective therapy.

About Zevalin(R)

Zevalin(R) (Ibritumomab Tiuxetan) is a form of cancer therapy called radioimmunotherapy and is indicated as part of the Zevalin therapeutic regimen for treatment of relapsed or refractory, low-grade or follicular B-cell non-Hodgkin's lymphoma, including patients with rituximab refractory follicular NHL. It was approved by the FDA in February of 2002 as the first radioimmunotherapeutic agent for the treatment of NHL.

Rare deaths associated with an infusion reaction symptom complex have occurred within 24 hours of rituximab infusions. Yttrium-90 Zevalin administration results in severe and prolonged cytopenias in most patients. Severe cutaneous and mucocutaneous reactions have been reported. The most serious adverse reactions of the Zevalin therapeutic regimen were primarily hematologic, including neutropenia, thrombocytopenia, and anemia. Infusion- related toxicities were associated with pre-administration of rituximab. The risk of hematologic toxicity
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SOURCE Cell Therapeutics, Inc.
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