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Intradigm Receives Notice of Allowance for Key RNA Interference (RNAi) Patent Covering Potent siRNA Sequence
Date:3/17/2009

Issuance Will Give Company Patents in Each of the Three Critical Areas of RNAi Therapeutic Development

PALO ALTO, Calif., March 17 /PRNewswire/ -- Intradigm Corporation, a leading developer of targeted, systemic RNA interference (RNAi) therapeutics, today announced that the United States Patent and Trademark Office (USPTO) has issued the company a notice of allowance for a patent covering various aspects of a potent small interfering RNA (siRNA) sequence. The allowed subject matter covers a specific double-stranded siRNA sequence that is directed against the angiogenic pathway and which possesses therapeutic potential in the treatment of cancer. This notice of allowance pertains to the first of a number of pending patent applications covering proprietary Intradigm siRNA sequences against more than 50 clinically relevant targets.

As the first sequence-specific patent for which Intradigm has received a notice of allowance, this development supplements the company's existing patents, giving Intradigm allowed intellectual property (IP) covering each of the three critical areas for RNAi therapeutic development: target sequences, delivery and structural features. This breadth of intellectual property places Intradigm in a uniquely strong position within the RNAi therapeutic industry, especially among other private companies in the space.

"The receipt of this notice of allowance provides us a great deal of confidence in our ability to successfully prosecute our large number of pending sequence patents and, in turn, build one of the industry's strongest siRNA sequence patent positions," said Philip Haworth, chief executive officer of Intradigm. "Additionally, once this patent issues, Intradigm will possess issued patents related to siRNA sequences, siRNA delivery technology and siRNA structural motifs. We believe this breadth of coverage provides the company with a key competitive advantage in the RNAi therapeutics space."

ABOUT INTRADIGM

Intradigm is a private biotechnology company committed to the discovery, development and delivery of targeted, systemic RNA interference (RNAi) therapeutics for the treatment of serious diseases with an initial focus on oncology. Intradigm is unique among private companies, with its comprehensive RNAi therapeutics platform consisting of structural features for next-generation RNAi molecules, biodegradable polycationic polymers for the delivery of RNAi therapeutics and proprietary siRNA sequence applications. Our proprietary delivery technology is unique in its potential to offer safe and effective systemic administration using a library of novel peptide-based biodegradable polymers.

We have established an impressive proprietary portfolio of siRNA sequences against more than 50 highly valued oncology and other disease targets. In addition, we have secured an exclusive license to the Zamore patent family from the University of Massachusetts, which covers broad structural features of siRNA design for more potent next-generation siRNA sequences. Our goal is to grow Intradigm to become a leading company in enabling the development of novel RNAi therapeutics against a broad range of therapeutic targets using our siRNA sequences and delivery technology.

For more information on Intradigm, please visit www.intradigm.com.


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SOURCE Intradigm Corporation
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