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Intradigm Licenses Key Next Generation RNA Interference (RNAi) Intellectual Property From University of Massachusetts Medical School
Date:4/9/2008

elf as a leader in the development and commercialization of novel RNAi therapeutics," said Mohammad Azab, M.D., president and chief executive officer of Intradigm. "We have established an impressive IP portfolio that spans the areas of siRNA structure and sequence, as well as RNAi delivery, providing us a distinct competitive advantage enjoyed by very few other companies."

"We are keenly aware of the critical role that the fundamental RNAi research being conducted in our labs may play in ultimately bringing novel RNAi therapeutics to patients who desperately need them," stated James P. McNamara, Ph.D., Executive Director of the Office of Technology Management at the University of Massachusetts Medical School. "For this reason, we are driven to align with leaders in the RNAi therapeutic space, such as Intradigm, to provide them access to our intellectual property and support their important drug development efforts. We are eager to witness Intradigm's progress and excited at that prospect of our IP playing a central role in the company's future success."

ABOUT THE RNAi NANOPLEX DELIVERY TECHNOLOGY

To address the issue of effective and targeted delivery of RNAi therapeutics, Intradigm has developed and in-licensed an extensive intellectual property portfolio around its proprietary RNAi Nanoplex (NPX) delivery technology. The RNAi NPX delivery technology is a modular, multi-component delivery vector that carries active siRNA molecules in its core with the flexibility to attach a Polyethylene Glycol (PEG) layer and/or a targeting ligand to the polymer-siRNA NPX to improve circulation half life and achieve selective distribution to the target tissue. At the core of the RNAi NPX delivery technology is Intradigm's proprietary peptide-based biodegradable polymer known as PolyTran(TM). PolyTran enables safe systemic delivery of the siRNAs. Additionally, this platform is unique in its ability to offer tissue specific targeting of siRNA through the attachm
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SOURCE Intradigm Corporation
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