Navigation Links
International team identifies 480 genes that control human cell division
Date:1/7/2008

PITTSBURGH A team of U.S., Israeli and German scientists used computational biology techniques to discover 480 genes that play a role in human cell division and to identify more than 100 of those genes that have an abnormal pattern of activation in cancer cells.

Malignant cells have lost control of the replication process, so detecting differences in cell cycle gene activation in normal and malignant cells provides important clues about how cancers develop, said Ziv Bar-Joseph, a Carnegie Mellon University computational biologist who led the study. These genes also are potential targets for drug therapy.

Unlike many cancer studies, which seek to identify missing genes that might cause cancer, this new research shows that genes can contribute to cancer in less obvious ways. What we see is that there are many genes that are present and yet still involved in cancer because they are not activated, or expressed, in the way they normally are, said co-lead author Itamar Simon, a molecular biologist at Hebrew University Medical School in Israel. Rather than cycling on and off as normally occurs when cell replication and development proceeds, these genes are expressed in a steady state or not at all.

The findings will be reported in the online Early Edition of the Proceedings of the National Academy of Science during the week of Jan.7.

The genes found to be deregulated in cancer cells include a few, such as PER2 and HOXA9 that already have been linked to cancer. Most have not, including at least three genes responsible for repairing genetic mutations that occur as DNA is duplicated in the cell.

The failure of the DNA repair genes to cycle in cancer cells raises the possibility that some mutations associated with cancer may not cause cancer. Some of the mutations may be caused by the non-cycling genes, rather than the other way around, said Bar-Joseph, an assistant professor of computer science and machine learning in the School of Computer Sci
'/>"/>

Contact: Byron Spice
bspice@cs.cmu.edu
412-268-9068
Carnegie Mellon University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. QED International Associates Announces Changes to the HealthShares(TM) Autoimmune-Inflammation and Neuroscience Indexes - Correction
2. QED International Associates Announces Changes to the HealthShares(TM) Autoimmune-Inflammation and Neuroscience Indexes
3. Baxter International Fourth Quarter 2007 Financial Results Conference Call
4. Statement of International Dairy Foods Association President and CEO Connie Tipton
5. BioMS Medicals pivotal international multiple sclerosis trial receives positive review from Data Safety Monitoring Board
6. Lucid Expands Support Internationally: Dr. Colin Stahel appointed Director for Asia Pacific Region
7. International Substance Detection Firm IDenta To Release New Lead Test Kit - Rash Of Toy Incidents Leads Company To Enter New Marketplace
8. International Human Rights Day Recognized by Terasem Movement, Inc.s Third Annual Colloquium on the Law of Transbeman Persons
9. Corium International, Inc. Announces Appointment of Phyllis Gardner, M.D. and Daniel G. Welch to Board
10. Chambers Joins PRA International as Senior Vice President of Human Resources
11. Daval International Limited Gains Approval for Phase IIB Trial of AIMSPRO(R)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... RI (PRWEB) January 22, 2015 Protocol ... , The growing team of brand-neutral, independent consultants, Protocol ... Philip Rogers explained that over the years, his company ... , Moroso, Town of Plainfield, as well as others. ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Controlled Substance ... Alliance, which helps companies check the legal requirements around ... expand to China. , As their international operations ... globally adopting software solutions built as a result of ...
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2Varian Honored Among World's 100 Most Sustainable Corporations 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... Nov. 29 AMDL, Inc. (Amex:,ADL), headquartered ... and Jilin China, through its wholly owned ... biopharma company and today,announced that Jade has ... Federation of Industry and Commerce for its ...
... Mass., Nov. 29 Merrimack Pharmaceuticals,Inc., a privately ... of novel treatments for autoimmune disease and cancer, ... from its Board of,Directors and the addition of ... a Director at Merrimack since May 2006. He,was ...
... (Nasdaq: MATK ) announced today that it ... Conference in San Francisco,CA. The conference is being ... Hotel.,Steve Dubin, CEO, will be presenting on Thursday, ... live audio webcast of Martek,s presentation can be ...
Cached Biology Technology:AMDL's Chinese Subsidiary Wins Key Brand Excellence Award for Anti-Aging Treatment 2Merrimack Pharmaceuticals Announces the Addition of Robert Gay to its Board of Directors 2Merrimack Pharmaceuticals Announces the Addition of Robert Gay to its Board of Directors 3
(Date:1/22/2015)... - Today, FindBiometrics, the leading source of biometrics industry news, interviews ... design. "When we launched FindBiometrics 12 years ago ... , founder and CEO of FindBiometrics. "Now it,s maturing very ... key players on a very broad scale.  We are known ...
(Date:1/22/2015)... , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... market, reports on the recent success of the Wocket™ smart wallet at ... Wocket smart wallet was named as one of the "11 Hot Products ... Best Products Launched At CES So Far" by Newseveryday.com and "The top ...
(Date:1/22/2015)... EyeLock, Inc. , a market leader of iris-based identity authentication ... to the new role of Senior Vice President of Mobile ... mobile platforms and wearable solutions for EyeLock,s technologies. Gerber brings ... semiconductor industry to his role at EyeLock, with expertise in ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2
... 2009 Kidney damage associated with the autoimmune disease lupus ... them to congregate in and attack the organs, researchers at ... In a separate study with an international team, the ... to protect the kidneys from a different sort of immune ...
... at Pembroke Mall , Virginia ... Turner Network Sales (TNS), the distribution, sales and marketing arm ... partnering with Cox Communications of Hampton Roads to ... a service designed to help prevent crimes against children by ...
... STERLING, Va., April 3 The General Services ... (ABBTECH) as a provider of Personal Identity Verification ... services, under Homeland Security Presidential Directive 12 (HSPD-12). ... their GSA Schedule 70 contract under the GSA ...
Cached Biology News:UT Southwestern researchers probe kidney damage, protection in lupus 2UT Southwestern researchers probe kidney damage, protection in lupus 3truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children 2truTV and Cox Offer Free Digital Fingerprinting to Help Prevent Crimes Against Children 3ABBTECH Staffing Services Certified by GSA as an HSPD-12 Managed Service Provider 2
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Rabbit Anti-Mouse Ym1 Polyclonal Antibody,...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
... Analysis of large numbers of samples may ... system which requires minimum operator attention. ... PowerStream software and interface CE 4900. The ... operates in Windows XP and Windows 98 and ...
Biology Products: