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International Guidelines for First-Line use of Freelite(TM) in Diagnosis and Management of Multiple Myeloma to be Published in "Leukemia"
Date:1/28/2009

In about 20% of patients with AL amyloidosis, the growth of abnormal plasma cells is more florid, and can be overtly cancerous - a condition known as myeloma. Myeloma cells gradually replace healthy bone marrow cells, leading to bone pain and infections. A patient with myeloma may develop (or present with) AL amyloidosis but it is rare for an AL amyloidosis patient (who does not have myeloma at presentation) to progress to advanced myeloma. Source: http://www.ucl.ac.uk/medicine/amyloidosis/nac/nac9.html.

About The Binding Site

The Binding Site Ltd. is a British based company specialising in the research, development and production of immunodiagnostic kits and reagents. The Binding Site manufactures a wide range of high quality and innovative products used in clinical laboratories world-wide. The business is divided into three main areas:-

    1) Freelite(TM), a novel and highly significant assay
       increasingly used for the diagnosis and monitoring of multiple myeloma
       (MM), a cancer of cells in the bone marrow. MM is the second most
       common blood cancer after non-Hodgkin's lymphoma. Considered almost
       untreatable only 20 years ago, huge strides have been made in the
       successful treatment of multiple myeloma with new drugs becoming
       available and new treatment regimes being assessed. Freelite has been
       used as a sensitive marker for the efficacy of some of these newer
       treatments and has helped clinicians gain a clear understanding of
       how some of these drugs are benefiting their patients. Furthermore,
       with numerous different therapies now available, treatment decisions
       which may have taken weeks or months can now be made in days thanks to
       the availability of sensitive and reliable results using Freelite.
       National and International guideli
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SOURCE The Binding Site Limited
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