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International Guidelines for First-Line use of Freelite(TM) in Diagnosis and Management of Multiple Myeloma to be Published in "Leukemia"
Date:1/28/2009

produce antibodies and are a specialised form of B-lymphocyte. In myeloma a single cell becomes malignant and produces a very large number of identical cells (a clone). In normal circumstances, the antibody molecules present in the blood are very varied in their structure, reflecting the large number of infections they may be required to combat. In patients with myeloma very large quantities of a single type of antibody are produced. This is called a paraprotein and it is present in the blood and/or urine in about 99% of cases. Normal antibody levels are almost always reduced in myeloma. This, combined with a slight reduction in numbers of neutrophils, leads to a susceptibility to infections which may be life-threatening. When there is no detectable paraprotein it is called non-secretory myeloma. Detection of a paraprotein is not sufficient to give a diagnosis of multiple myeloma, as this may also occur in other conditions including lymphoma, MGUS, amyloidosis and some inflammatory disorders. Source: http://www.lrf.org.uk/en/1/infdispatmul.html.

About AL amyloidosis

AL amyloidosis used to be called 'primary systemic amyloidosis' and is now the most commonly diagnosed form of the disease. Patients with AL amyloidosis have an abnormal line of cells (called plasma or B cells) which are usually in the bone marrow, and which produce the amyloid forming protein. The AL amyloid forming protein is part of a protein called monoclonal immunoglobulin; the part that forms AL amyloid is called the light chain. Abnormal free light chains can be measured in the blood in about 95% of patients with AL amyloidosis. The underlying bone marrow disorder/monoclonal immunoglobulin producing disorder is known by many different names (plasma cell disorder, plasma cell dyscrasia, paraprotein disorder, monoclonal gammopathy, etc), and is very subtle in 80% of patients.
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