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Interleukin-6 Inhibitor Sirukumab (CNTO 136) Phase 2 Data Show Promise in the Treatment of Active Rheumatoid Arthritis
Date:5/25/2011

LONDON, May 25, 2011 /PRNewswire/ -- Results from a Phase 2 multicenter, randomized, double-blind, proof-of-concept and dose-finding study showed that treatment with sirukumab (CNTO 136) improved signs and symptoms of rheumatoid arthritis (RA) in patients with active disease despite treatment with methotrexate (MTX).  Findings from Part A of the two-part trial presented at the 2011 European League Against Rheumatism (EULAR) Congress showed that a greater proportion of patients receiving sirukumab achieved a significantly greater reduction in Disease Activity Score 28 (DAS28 CRP) at week 12, the primary endpoint of the study.  All patients in this study were continued on MTX.  Sirukumab is a human monoclonal IgG1 kappa antibody that targets the cytokine interleukin (IL)-6 and is currently in Phase 2 study investigating its use in moderately to severely active RA as a subcutaneously administered treatment.

RA is a chronic, systemic inflammatory condition that is characterized by symptoms that include pain, stiffness and inflammation, and in some cases, joint destruction and disability.  It is estimated 1.5 million Americans(1) and more than 23.5 million people worldwide(2) are affected by the condition, for which there is no cure.

"Not all patients respond to initial treatment, and in my experience a proportion of patients receiving currently available therapies will either have an inadequate response or lose response over time," said Josef Smolen, M.D., Professor of Medicine at the Department of Internal Medicine at the Medical University of Vienna, Austria, and study investigator.  "There continues to be a need for additional therapeutic options for the treatment of rheumatoid arthritis, a serious, progressive autoimmune disease. The results we have seen to date with sirukumab are promising, and we look forward to seeing future data from the ongoing clinical studies."

Investigators reported data from Part A of the s
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SOURCE Centocor Ortho Biotech Inc.
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