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InterMune Reports Second Quarter 2008 Financial Results and Business Highlights
Date:7/31/2008

e its goal of having no more than 5% of

patients lost to follow-up at the time of the week 72

assessment.

ITMN-191:

-- On April 2, InterMune reported top-line results in the four dose

cohorts of treatment-naive patients chronically infected with

hepatitis C virus (HCV) genotype 1 in its Phase 1b multiple-

ascending-dose (MAD) monotherapy trial of ITMN-191:

-- Day 14 median viral kinetic results competitive with those

published for other direct antiviral compounds when used in

monotherapy for 14 days. Specifically, InterMune reported a

median 3.8 log reduction (equal to 99.98% reduction) in HCV RNA

from baseline at Day 14;

-- Significant and rapid viral kinetic activity when dosed every

12 hours; and

-- Excellent safety and tolerability in all dosage regimens.

-- InterMune reported successful completion of 13-week toxicology

studies in rats and monkeys at exposures higher than those expected

to be evaluated in clinical studies. These preclinical studies were

required before initiating the Phase 2 program of ITMN-191 which

will involve durations of therapy longer than those studied in Phase

1.

-- Announced on May 29 the initiation of a 14-day study of ITMN-191 in

combination with Pegasys(R) (pegylated interferon alpha-2a) and

Copegus(R) (ribavirin). The study is proceeding as planned.

-- Submitted several abstracts for possible presentation at the 59th

Annual Meeting of the American Association for the Study of Liver

Diseases (AASLD) to be held October 31 - November 4, 2008 in San

Francisco, including but not limited to data on ITMN-191.

Financial:

-- On June 24, InterMune exchanged $85 million
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SOURCE InterMune, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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