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Intensive Lifestyle Intervention Program for Overweight or Obese Patients with Nonalcoholic Steatohepatitis Reduces Weight and Improves Overall Liver Health
Date:10/27/2008

Research to be presented Sunday, November 2, 2008 at this year's liver

meeting in San Francisco, California, October 31 - November 4

SAN FRANCISCO, Oct. 27 /PRNewswire/ -- Nonalcoholic steatohepatitis (NASH) is strongly associated with obesity, and there is no approved medical therapy for this chronic progressive liver disease. Researchers tested the effects of weight reduction using a state-of-the-art lifestyle intervention program. To do so, 31 overweight or obese patients with NASH were randomized into two groups. Subjects in the first group were put on a lifestyle intervention program consisting of diet, exercise, and behavior modification. Those in the second group received standard nutrition counseling.

According to Kittichai Promrat, MD, principal investigator of the study, "The lifestyle intervention program focuses on changing both eating and exercise habits with a goal of producing a 7-10% weight loss. Participants were seen weekly in small groups (3 to 5 members) conducted by a Master's level nutritionist or health educator for the first 6 months and bi-weekly during the latter 6 months of the program."

After 48 weeks, those on the lifestyle intervention program successfully lost about 9% of their weight, and had significantly greater improvements in liver biopsy findings (hepatic steatosis and overall histologic NASH activity score), and more improved liver enzyme levels compared to those in the control group. Dr. Promrat concludes, "We were extremely encouraged by the results. Weight loss through lifestyle intervention program improves NASH. This approach should be further evaluated in larger trial."

Abstract title:

Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis (NASH)

AASLD is the leading medical organization for advancing the science and practice of hepatology. Founded by physicians in 1950, AASLD's vision is to prevent and cure liver diseases. Thi
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SOURCE AASLD
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