Navigation Links
Integrated Analysis Demonstrates Alpha(1)-Augmentation Therapy Significantly Reduces Loss of Lung Tissue in Patients with AAT-deficiency-related Emphysema
Date:11/15/2010

for the AAT treatment group and -6.379g/L for the placebo group, a statistically significant difference of 2.297 (95% CI, 0.669 to 3.926; p = 0.006).

"The mean data from the integrated analysis demonstrate a deceleration of lung tissue loss with AAT augmentation therapy versus placebo with statistical significance," said Stockley.

The effect of augmentation therapy with any Alpha(1)-proteinase inhibitor (A1PI) on pulmonary exacerbations and on the progression of emphysema in Alpha(1)-antitrypsin deficiency has not been demonstrated in a single, prospective, randomized, controlled clinical trial.

The two clinical trials included in the integrated analysis were a three-year Danish-Dutch study of 56 patients (http://ajrccm.atsjournals.org/cgi/content/full/160/5/1468) and the EXAcerbations and CT scan as Lung Endpoints (EXACTLE) trial of 77 patients over 24 to 30 months (http://erj.ersjournals.com/content/33/6/1345.full).  In both trials, patients were randomized to receive infusions of A1PI or a placebo.  The results suggested a trend toward reduction in emphysema progression with A1PI therapy, as measured by CT densitometry. The trials were not powered to show efficacy; thus neither trial reached statistical significance on its own. Pooling the data increased the number of patients and the statistical power of the analysis.

Talecris Biotherapeutics, manufacturer of PROLASTIN®-C (Alpha(1)-Proteinase Inhibitor [Human]), funded the integrated analysis and the EXACTLE trial included in the analysis.

About PROLASTIN®-C

PROLASTIN-C is indicated for chronic augmentation and maintenance therapy in Alpha(1)-antitrypsin (AAT) deficiency in patients with emphysema.  AAT deficiency is a genetic condition in which low level
'/>"/>

SOURCE Talecris Biotherapeutics
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Golub Capital Provides Financing to Support The Recapitalization of Integrated DNA Technologies, Inc.
2. ClearTrial Selected to Provide Methodologies for Accurately Forecasting and Budgeting Clinical Spend and Integrated Financial Controls at CBI Conference
3. All TT Electronics Integrated Manufacturing Services Facilities Accredited with Medical Manufacturing Standard
4. Thomson Reuters is First to Offer Fully Integrated Pipeline and Clinical Trials
5. Integrated Electrical Services Awarded Contract to Provide Electrical Systems for U.S. Army Medical Research Institute of Infectious Diseases
6. Xybion Unveils Pristima™ VM, an Integrated Enterprise Software Solution for Vivarium and Veterinary Care Management
7. PDI and Physicians Interactive Partner To Provide Integrated, Personal and Digital Solutions to Life Sciences Companies
8. China Integrated Energy, Inc. Announces Preliminary Third Quarter Financial Results and Increases Full Year Guidance
9. China Integrated Energy, Inc. Announces Eight Million Share Public Follow-On Offering
10. CapitalBio Corporation and VigeneTech Inc. Have Announced the Launch of a Fully Integrated Microarray Solution Platform
11. Shanghai ChemPartner and Agios Expand Integrated Drug Discovery Research Collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Nematicide is a type of chemical ... parasitic roundworms, found in massive quantities virtually everywhere—in ... animals. Nematicides have tended to be broad-spectrum toxicants ... through the soil. A single gram of soil ... more than 10,000 species classified, they are one ...
(Date:9/30/2014)... Over the last decade, the laboratory filtration market is ... increased acceptance of new filtration technologies in end users ... also catalyzing the growth of laboratory filtration market. , ... at a strong CAGR during the forecast period of ... by 2019. The market is mainly driven by the ...
(Date:9/30/2014)... 30, 2014 Proove Biosciences , ... excited to announce a new genetic test built upon ... Pain Perception Test will provide physicians with an ... pain tolerance levels are stratified between individuals. With this ... a person has a genetic predisposition that will affect ...
(Date:9/30/2014)... Jose, California (PRWEB) September 30, 2014 ... measure the level of each type of cholesterol carrier ... since the presence of excessive cholesterol levels in the ... a precursor condition to heart attack and other cardiovascular ... fatality worldwide, therefore testing for cholesterol levels on a ...
Breaking Biology Technology:Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... available in German . , Researchers at ... France and UK, have engineered a material that exhibits ... temperature. It,s called a "multiferroic," and it means that ... electrically charged (ferroelectric) and also the ability to be ...
... Fla., Aug. 22, 2011 BioRestorative Therapies, Inc. (OTCQB: ... Company,s filing of its Quarterly Report on Form 10-Q with ... now being traded on the OTCQB market, the middle tier ... that are subject to the reporting requirements of the SEC, ...
... from the University of the Basque Country (Spain) has ... liquids seized by police and suspected to be explosive. ... health, such as methanol and boric acid. Each ... in principle, are for indoor firework manufacturing (i.e. flares ...
Cached Biology Technology:Locating the elusive 2BioRestorative Therapies, Inc. Announces Upgrade to OTCQB Market 2Are those liquids explosive? 2
(Date:9/30/2014)... led by Clemson University associate professor Brian Powell, ... the U.S. Department of Energy,s Experimental Program to ... impact on South Carolina in the advancement of ... "Understanding the scientific and engineering needs for safely ... technologies is imperative if South Carolina is to ...
(Date:9/30/2014)... drinking water may increase the risk of stillbirth ... led by a Boston University School of Public ... journal Environmental Health , compared 1,091 PCE-exposed ... in Cape Cod, Ma., where water was contaminated ... by the installation of vinyl-lined asbestos cement pipes. ...
(Date:9/30/2014)... England Journal of Medicine reports positive results of ... against the subset of lung cancer marked by rearrangement ... 50 patients with advanced non-small cell lung cancer testing ... 72 percent, with 3 complete responses and 33 partial ... for the disease to resume its growth after being ...
Breaking Biology News(10 mins):Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Contaminated water linked to pregnancy complications, BU study finds 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2
... research and reform in American immigration law must go ... (ASCB) declared today in a position paper that outlines ... "Despite having the best research and educational institutions in ... significant hurdle for retaining the world,s most promising scientists ...
... to a wide cross-section of human society, both as a ... less well understood is the global nature of this association ... and societies. This relationship is explored by David Wilson of ... of Melbourne in Australia in a paper published in the ...
... is the first time that a clear link has been ... birth and risk of Autism Spectrum Disorder and follows from ... Sweden. , The research, led by The University of Manchester, ... grown, low weight babies appear more susceptible to the condition. ...
Cached Biology News:Cell biologists say immigration reform critical to scientific education and competitiveness 2Is the humble fig more than just a fruit? 2Bigger birth weight babies at greater risk of autism 2
100 g monoclonal antibody which can immunocapture ~10 g of Complex IV from heart mitochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture....
Rabbit polyclonal to GPR56 ( Abpromise for all tested applications). entrezGeneID: 9289 SwissProtID: Q9Y653...
...
Tube-O-DIALYZER Floats, small....
Biology Products: