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Intarcia Therapeutics, Inc. Presents ITCA 650 Phase 1b Study Results as a Late-Breaker at the American Diabetes Association 69th Scientific Sessions
Date:6/8/2009

DUROS(R) continuous delivery of exenatide produces impressive reductions in fasting plasma glucose, HbA1c and body weight during 28-day treatment

NEW ORLEANS, June 8 /PRNewswire/ -- Intarcia Therapeutics, Inc. today presented results from the first clinical study of ITCA 650 (DUROS(R) continuous delivery of exenatide) for the treatment of type 2 diabetes as a late-breaker at the Annual Conference of the American Diabetes Association in New Orleans, LA (June 5-9, 2009). Results of the phase 1b study demonstrate substantial reductions in fasting plasma glucose (FPG) within 24 hours of the start of treatment and a sustained glucose lowering effect throughout the 28 day treatment period. Other important results from the study were substantial reductions in postprandial glucose (PPG), HbA1c and body weight.

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"This study was designed to evaluate a more effective and patient-friendly approach to deliver exenatide therapy for the treatment of type 2 diabetes," said K. Alice Leung, President & CEO of Intarcia Therapeutics, Inc. "ITCA 650 ensures that patients receive the benefits of an optimized dose of exenatide immediately upon initiation of treatment, and it continuously provides consistent, round-the-clock control of blood glucose without requiring patients to inject themselves."

The phase 1b dose ranging study was conducted at multiple centers in the United States and evaluated a 28-day course of ITCA 650 treatment among 44 type 2 diabetes patients (10-12 patients/dose arm) on a stable treatment regimen of diet and exercise or treatment with metformin and/or thiazolidinediones. The study included four dose arms to which patients were randomized to receive 10 mcg/day, 20 mcg/day, 40 mcg/day or 80 mcg/day exenatide for a 28 day treatment duratio
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