Navigation Links
Insero Health Reports Positive Data on Phase I Trial of Novel Therapy for Drug-resistant Epilepsy
Date:5/17/2013

MIAMI, May 17, 2013 /PRNewswire/ -- Insero Health, Inc., a company developing natural compounds to address unmet medical needs in epilepsy and related neurological disorders, is today reporting top-line results from a Phase Ib trial of its lead compound INS001 in patients with drug-resistant epilepsy.  The data are being presented at the AntiEplileptic Drug and Device Trials (AED) Xll meeting by Dr. Steven Schachter , Harvard Medical School epileptologist and Chairman of Insero's Scientific Advisory Board.  In this study, INS001 appeared safe and well tolerated.

INS001 is a naturally occurring compound that has shown promising activity in multiple preclinical epilepsy models.  Insero researchers believe that INS001 exerts its anti-epileptic effects through a unique combination of mechanisms: it is both a potent acetylcholinesterase inhibitor and an NMDA-receptor antagonist.  The compound has previously demonstrated good safety and signs of therapeutic activity in a Phase II trial in Alzheimer's disease, as well as in preclinical models of multiple sclerosis and neuropathic pain.

The Phase I trial was a single-center, inpatient, open-label, rapid dose escalation study in patients with drug-resistant epilepsy.  INS001 was safe and well tolerated at doses expected to be therapeutic, and increased cardiac parasympathetic tone and electrical stability were observed.

Dr. Schachter noted, "The positive safety demonstrated in this first trial of INS001 in drug-resistant epilepsy is a step forward in the clinical development of this therapy as a potential new treatment option for patients with epilepsy whose seizures are inadequately treated today."

Insero expects to initiate a Phase II proof of principle trial in patients with drug-resistant epilepsy by early next year.

Epilepsy affects about three million people in the U.S. and over 50 million people
'/>"/>

SOURCE Insero Health, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. HealthSparq to Reveal New Healthcare Transparency Benchmark Study at AHIP Institute 2013
2. Best Practices for Tracking Tissue in the Healthcare Supply Chain, Webinar Hosted by Xtalks
3. Cambrex To Present At UBS Global Healthcare Conference
4. Ampio Pharmaceuticals Announces Participation at the UBS Global Healthcare Conference
5. Orexigen Therapeutics to Present at the Bank of America Merrill Lynch 2013 Health Care Conference
6. ViroPharma To Participate In Two May Healthcare Investor Conferences
7. PrimeraDx Featured in the Goldman Sachs Healthcare Research Teams GS Emerging Healthcare Series
8. Sangamo BioSciences Announces Presentation at the Bank of America Merrill Lynch 2013 Health Care Conference
9. Neurocrine Biosciences To Present At The Bank of America Merrill Lynch 2013 Health Care Conference
10. CellHealth Institute is Named 2013 Edison Award Winner
11. AtheroNova Announces Approval for Phase 1 by the Russian Ministry of Healthcare with Commencement of Human Trials Imminent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 2014  The In Silico Drug Discovery Conference today ... at the conference, which takes place at North Carolina ... 4, 2014. Researchers, students, drug developers, business development professionals, ... KEYNOTE SPEAKERS Ruben ... of Pharmacy Drug Discovery with Three Dimensional ...
(Date:9/17/2014)... JH Technologies announces the grand opening ... JH Technologies, a leader in sales and support of ... partnership with Leica Microsystems into the Southern California market. ... will be featured at the grand opening slated for ... is located within the JH Technologies office’s at 18025 ...
(Date:9/17/2014)... 2014 Hussey Copper , a leader ... antimicrobial copper, announces Gilmour Academy Ice Arena,s conversion of ... antimicrobial solid touch surface to help protect against bacteria.  ... surface that kills greater than 99.9% of MRSA, E-coli ... , Innovative ...
(Date:9/17/2014)... de septiembre de 2014  Cryoport, Inc. ... mundial de soluciones logísticas avanzadas criogénicas para ... vida, anunció hoy la contratación de Broekman ... sede en Rótterdam, Países Bajos, para proporcionar ... en rápido crecimiento. Según los términos del ...
Breaking Biology Technology:In Silico Drug Discovery Conference Announces Speakers and Topics 2In Silico Drug Discovery Conference Announces Speakers and Topics 3In Silico Drug Discovery Conference Announces Speakers and Topics 4In Silico Drug Discovery Conference Announces Speakers and Topics 5In Silico Drug Discovery Conference Announces Speakers and Topics 6In Silico Drug Discovery Conference Announces Speakers and Topics 7JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 2JH Technologies displays newest microscope imaging technology at Southern California showroom grand opening 3Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Innovative Gilmour Academy Ice Arena changes more than 200 fixtures to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5
... FRANKLIN LAKES, N.J., May 27 Collagen Matrix, ... States Food and Drug,Administration,s 510(k) clearance of its ... protection of tendon injuries in which,there has been ... Collagen Tendon Wrap is a resorbable type 1 ...
... Planned for September 2008, PLYMOUTH MEETING, Pa., May ... (,BMP Sunstone, or the ,Company,),today announced that it has ... market a new Propess applicator in China., Prior ... dilation to,help induce labor, and is currently distributed via ...
... Judges for Nikon Small World, MELVILLE, N.Y., ... received a record number of entries for the ... by over 300,images. The oldest and most respected ... world,s best photomicrographers who create beautiful,imagery while showing ...
Cached Biology Technology:Collagen Matrix, Inc. Receives FDA 510(k) Clearance for TenoMend(TM) Collagen Tendon Wrap for the Management and Protection of Tendon Injuries 2BMP Sunstone Receives Import Drug License (IDL) from SFDA 2BMP Sunstone Receives Import Drug License (IDL) from SFDA 3Nikon Instruments Receives Record Number of Entries for Nikon Small World 2
(Date:9/17/2014)... USA -- "Nature has developed, very cleverly, some lessons ... in optical design," said Joseph Shaw, director of the ... explore surfaces and structures at the nanoscale, we,ll discover ... San Diego in August during a conference called "The ... and Rongguang Liang of the University of Arizona College ...
(Date:9/17/2014)... Institute of Oncology-Bellvitge Biomedical Research Institute (ICO-IDIBELL), led ... expressed in normal accompanying cells in colorectal tumors. ... classify colorectal tumors, predict the evolution of the ... prevent relapses. , Biomarkers , ... population considering both sexes. About 30,000 new cases ...
(Date:9/17/2014)... faster since the 1960s. The typical development phases of ... accelerated -- by as much as 70 percent. This ... scientists from Technische Universitt Mnchen based on long-term data ... since 1870. Their findings were published recently in ... was a hot topic, with the very survival of ...
Breaking Biology News(10 mins):Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3Five genes to predict colorectal cancer relapses 2Global change: Trees continue to grow at a faster rate 2Global change: Trees continue to grow at a faster rate 3
... new study reports for the first time that a less-virulent ... humans. The research appears in the October 1 issue ... Crossing the species barrier is an important step in the ... have focused on the ability of highly pathogenic strains, such ...
... a new study reports for the first time that a ... to humans. The research appears in the October 1 ... , Crossing the species barrier is an important step in ... studies have focused on the ability of highly pathogenic strains, ...
... trials ever, researchers have found that an experimental vaccine ... of shingles--a painful nerve and skin infection--and dramatically reduced ... the disease. The findings appear in the June 2 ... The Shingles Prevention Study, conducted over 5 ½-years, was ...
Cached Biology News:First Whole Genome Map of Genetic Variability in Parkinson’s Disease 2Transplanting Animal Organs Could Soon Be A Reality 2Experimental shingles vaccine proves effective in nationwide study 2Experimental shingles vaccine proves effective in nationwide study 3Experimental shingles vaccine proves effective in nationwide study 4
... This kit is designed for the ... large vector plasmids at any position (for ... included FRT-PGK-gb2-neo-FRT cassette is designed to allow ... eukaryotic cells. It combines a prokaryotic promoter ...
... Agencourt AMPure is a magnetic ... requires no sample transfer, centrifugation ... purifies small and large PCR ... 384-well microplates. Agencourt AMPure can ...
Kit includes your choice of reagents for labeling 3 x 10 9 cells and EasySep magnet....
Plasmid expressing PLAP reporter gene....
Biology Products: