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Inovio Pharmaceuticals Reports Long-Term Immune Responses from Therapeutic Cervical Dysplasia and Cancer DNA Vaccine
Date:5/9/2011

itive responders as well as 3 of 5 patients who were non-responders at month 4. These patients were subsequently monitored through to study completion at month 9 (six months post last vaccination).  As expected, all three non-responders at month 4 still did not show a T cell response at month 9. In contrast, 91% of evaluated patients (10 of 11) displayed strong and persistent memory T-cell responses at month 9. Importantly, the level of T cell responses remained strong, with responses ranging from 100 to over 3800 SFU. These results are consistent and add validation to similar levels of persistent and strong T cell responses at month 9 observed by Inovio from its PENNVAX™ HIV vaccine studies in non-human primates.

Generation of T cell responses is considered instrumental in clearing cancerous cells from the body and imperative to achieving sufficient potency of new therapeutic vaccines against cancers. Achieving a sustained, durable immune response provides the prospect that the body will maintain a prolonged vigilance and fight against precancerous and cancerous cells of the cervix. Such persistent memory T cell responses previously have not been reported using other vaccine platforms, including competing viral vector programs. Additionally, the sustained T cell responses at month 9 reported here are at least ten-fold higher than those presented by competing vaccine candidates even at their peak short-term level.

"These results demonstrate the powerful potential of our SynCon™ VGX-3100 vaccine delivered using our proprietary CELLECTRA® electroporation system as well as the capabilities of our proprietary vaccine platform," said Dr. J. Joseph Kim, Inovio's president and CEO.  

"Based on the compelling data achieved from our Phase I cervical dysplasia clinical study, we are now evaluating the efficacy of VGX-3100 delivered using our CELLECTRA®

SOURCE Inovio Pharmaceuticals, Inc.
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