Navigation Links
Inovio Pharmaceuticals Reports Long-Term Immune Responses from Therapeutic Cervical Dysplasia and Cancer DNA Vaccine
Date:5/9/2011

BLUE BELL, Pa., May 9, 2011 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE Amex: INO), a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, has reported data demonstrating long-term durability of immune responses induced by VGX-3100, its investigational DNA vaccine for treating cervical dysplasia and cancer caused by human papillomavirus (HPV). These results were presented at the 15th Annual Conference on Women's Health Care Issues, hosted in New York by the International Infectious Disease Society for Obstetrics and Gynecology-USA, by Mark Bagarazzi, MD, Inovio's chief medical officer.

The data were generated through a long-term assessment of participants in Inovio's Phase I study of 18 adult females with moderate or severe cervical intraepithelial neoplasia (CIN 2/3), a high-grade premalignant lesion that may lead to cervical cancer. This study was designed to assess immune responses generated by and safety of the vaccine.

In this study, 72% of vaccinated subjects (13 of 18) developed significant antigen-specific T-cell responses during the first four months of treatment (each patient was vaccinated at months 0, 1, and 3) by standardized interferon-γ ELISpot assay. The third and highest dose group displayed the strongest level of T cell responses, with 83% (5 of 6) positive responders. The level of T cell responses in positive responders ranged from 100 to over 5000 spot forming units (SFU) per million cells when measured after overnight stimulation in the standardized ELISpot assay. In contrast, competing vaccine approaches targeting HPV therapy have consistently shown sub-100 SFU levels even when using more sensitive assays.

This newly reported data evaluated 11 of 13 pos
'/>"/>

SOURCE Inovio Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Inovio Pharmaceuticals Enters Phase II Clinical Trial with SynCon™ DNA Vaccine for Cervical Dysplasia Caused by HPV
2. Inovio Pharmaceuticals Foot-and-Mouth Disease DNA Vaccine Introduces Critical Advantages in Fight Against Most Serious Farm Animal Disease
3. Inovio Pharmaceuticals to Present at 13th Annual BIO CEO & Investor Conference
4. Vanda Pharmaceuticals Reports First Quarter 2011 Results
5. MAP Pharmaceuticals Reports First Quarter of 2011 Financial Results
6. Anadys Pharmaceuticals to Report First Quarter 2011 Financial Results
7. Keryx Biopharmaceuticals, Inc. Announces First Quarter 2011 Financial Results
8. Keryx Biopharmaceuticals, Inc. To Host Conference Call on First Quarter 2011 Financial Results
9. Keryx Biopharmaceuticals Announces Positive Final Data from Zerenex™ Short-Term Phase 3 Study
10. Optimer Pharmaceuticals and Clinical Investigators to Present Data at Upcoming Medical Meetings
11. Auxilium Pharmaceuticals to Announce First Quarter 2011 Results and Conduct Conference Call on Monday, May 9, 2011
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire/ - iCo Therapeutics ... today reported financial results for the six months ... are expressed in Canadian dollars and presented under ... Quarter 2014 Highlights , Announced top-line ... (VA) primary endpoint for subjects enrolled in the ...
(Date:8/29/2014)... Due to a misstatement posted by the ... Cell Technology Center, LLC ( ASCTC ) was reported as ... that might benefit ALS patients. Because of ASCTC's exclusive ... technologies and therapeutic applications, FRC listed ASCTC as one of ... who wish not to support research that requires the death ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 SPIE Fellow ... Physics and Optical Science and Director of the Center ... North Carolina at Charlotte, and co-founder and Chairman of ... serve as the 2015 Vice President of SPIE, the ... President Philip Stahl announced recent election results at the ...
(Date:8/28/2014)... “This kit has an improved extraction efficiency and provides users ... said Mark Tess, PhD, Mycotoxin Product Manager for Charm Sciences. ... USDA-GIPSA inspection agencies that have a need to detect aflatoxin ... a matter of minutes with nothing but our equipment and ... grain before accepting it, but they no longer have to ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... SAN DIEGO, Jan. 13 NexBio, a privately held ... that David Wurtman, MD, MBA, Vice President of Corporate ... 2009 Biotech Showcase in San Francisco, CA, on January ... to save lives and to improve the quality of ...
... BOSTON, Jan. 13 Johnston Blakely & Company, ... to announce that Michael,D. Webb has joined the ... Mr. Webb will,participate with the firm on internal ... and private equity placements, with a,particular focus on ...
... HOPE, Pa., Jan. 13 Jubilant Organosys,Ltd., ... today that its,Bangalore-based subsidiary, Jubilant Biosys Ltd., ... BioLeap, LLC, USA. Under this partnership, ... computational fragment,based drug design platform with Jubilant,s ...
Cached Biology Technology:NexBio to Present at 2009 Biotech Showcase 2NexBio to Present at 2009 Biotech Showcase 3Jubilant and BioLeap Announce New Partnership in Drug Discovery 2Jubilant and BioLeap Announce New Partnership in Drug Discovery 3
(Date:8/29/2014)... Kansas City, MO. - In a cell,s nucleus, ... known as histones, an amalgam biologists call chromatin. ... as a nuclear "sidekick," the mere packing material ... Recently, however, biologists have developed a greater appreciation ... In 2012, investigators from multiple research institutions studying ...
(Date:8/28/2014)... America (ESA) is pleased to announce the selection of ... Society. Honorary Membership acknowledges those who have served ESA ... the affairs of the Society that has reached an ... the ESA Governing Board and then voted on by ... the Awards Ceremony at Entomology 2014, ESA,s Annual Meeting ...
(Date:8/28/2014)... traditional cigarettes, but still release toxins into the ... , Scientists studying secondhand smoke from e-cigarettes discovered ... particles, with close-to-zero exposure to organic carcinogens. However, ... second-hand e-cigarette smoke were found to be significantly ... of polycyclic aromatic hydrocarbons cancer-causing organic compounds ...
Breaking Biology News(10 mins):'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3Fred Baxendale selected as Honorary Member of the Entomological Society of America 2Second-hand e-cig smoke compared to regular cigarette smoke 2
... A team of researchers, led by biologists at Dartmouth, ... in Lake Baiyangdian, the largest lake in the North ... drinking water for the people who live around it. ... Lake Baiyangdian, all at varying distances from major sources ...
... Is getting new knees on your list of New ... indicates that women wait longer to pursue knee-replacement surgery ... can no longer stand the pain, these women may ... on hold indefinitely, according to Lynn Snyder-Mackler, Distinguished Alumni ...
... If youre worried about high cholesterol levels and keeping ... and eggs just yet. A new study says they ... University have discovered that lower cholesterol levels can actually ... assistant professor of health and kinesiology, and Simon Sheather, ...
Cached Biology News:Dartmouth researchers alarmed by levels of mercury and arsenic in Chinese freshwater ecosystem 2Listen-up ladies: Don't postpone knee-replacement surgery 2Listen-up ladies: Don't postpone knee-replacement surgery 3Surprise -- cholesterol may actually pose benefits, study shows 2
Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
EPH electrode, cathode, 1. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
... paraffin tissue array is designed for ... interest in extensive panels of different ... heart, kidney, liver, lung, muscle, spleen ... positively charged glass slide. Each ...
Rat Normal Multiple Tissue Array 1 slide...
Biology Products: