Navigation Links
Inovio Pharmaceuticals' Prostate Cancer DNA Vaccine Demonstrates Strong T Cell Responses in Monkeys; Company on Track for Phase I Clinical Trial
Date:6/29/2011


For its cervical cancer vaccine, Inovio is currently conducting a randomized, placebo controlled, double blind Phase II study evaluating the effects of VGX-3100 treatment on the clearance of moderate or severe cervical intraepithelial neoplasia (CIN 2/3) cervical lesions. A total of 148 patients will be enrolled in 25 study centers in the US, Korea, South Africa, Australia, and Canada.

In a previous Phase I study of 18 adult females with CIN 2/3 stages, 72% of vaccinated subjects (13 of 18) developed significant antigen-specific T-cell responses during the first four months of treatment (each patient was vaccinated at months 0, 1, and 3) by standardized T cell assay. Furthermore, 91% of evaluable responders (10 of 11) displayed strong and persistent memory T-cell responses at month 9, with strong T cell responses.

In the Phase I escalating dose study, all three dose groups experienced significant antigen specific antibody and T-cell immune responses against multiple antigens. In the third and final dose group, five of six (83%) patients developed the highest level of T-cell responses achieved by any non-replicating vaccine platform in patients to date.

The leukemia study, pWT1, utilizing Inovio's electroporation delivery technology, is a single dose, Phase II trial currently recruiting up to 170 CML and AML patients. This leukemia trial is being conducted in a collaboration with the University of Southampton. All vaccinated subjects will initially receive six doses of two DNA vaccines (called p.DOM-WT1-37 and p.DOM-WT1-126) delivered at four week intervals. Vaccine responders may continue with booster vaccinations every three months out to 24 months. The study will also have control AML/CML patients enrolled across the two arms as non-vaccinated controls for comparison. The primary endpoints will be molecular response to a disease marker called BCR-ABL in CML patients and time to disease progression in AML patients. The study will also
'/>"/>

SOURCE Inovio Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Inovio Pharmaceuticals to Present at 13th Annual BIO CEO & Investor Conference
2. Inovio Pharmaceuticals Foot-and-Mouth Disease DNA Vaccine Introduces Critical Advantages in Fight Against Most Serious Farm Animal Disease
3. Inovio Pharmaceuticals Enters Phase II Clinical Trial with SynCon™ DNA Vaccine for Cervical Dysplasia Caused by HPV
4. Inovio Pharmaceuticals Reports Long-Term Immune Responses from Therapeutic Cervical Dysplasia and Cancer DNA Vaccine
5. Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2008 Financial Results on Monday, August 11, at 8:30 A.M. EDT
6. ISTA Pharmaceuticals Reports Second Quarter 2008 Financial Results
7. SGX Pharmaceuticals Announces Financial Results for the Three and Six Months Ended June 30, 2008
8. ADVENTRX Pharmaceuticals to Report Second Quarter 2008 Results
9. Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121, an ErbB3 Antagonist
10. VIA Pharmaceuticals to Present at Fourth Annual Noble Financial Equity Conference
11. Anthera Pharmaceuticals Completes $19 Million Financing; Appoints Christopher S. Henney as Chairman
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... , Aug. 20, 2014 Clintrax ... services located in Raleigh, NC ... Evans as Vice President of Administration. ... will oversee all corporate processes, including their alignment ... Clintrax Global, Brad worked as an HR executive, ...
(Date:8/20/2014)... to biotechnology firms has revealed early bottlenecks on ... the researchers suggest that better communication of basic ... to faster commercialization down the road. , Biopharmaceutical ... university laboratories and licensed to biotechnology firms. Bottlenecks ... a high failure rate. But a new study ...
(Date:8/20/2014)... history lessons often have it that American Indians largely ... chicken pox, influenza and tuberculosis brought to the New ... vary, about 20 million people lived in the Americas ... them were killed by European diseases., But new research ... University and Johannes Krause of the University of Tubingen ...
(Date:8/20/2014)... succeeded in measuring vibrational motion of a single molecule ... vibration of a single molecule differs from the behaviour ... performed at the University of California, Irvine, where post-doctoral ... as a visiting fellow under professor Vartkess A. Apkarian, ... was lead by Professor Eric O. Potma. The results ...
Breaking Biology Technology:Clintrax Global, Inc. Announces Addition to Executive Team 2Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3Seeing a molecule breathe 2
... 29, 2011 University of Utah chemists developed a method ... speed chemical reactions and are crucial for producing energy, chemicals ... also made a discovery that will make it easier to ... properties of catalysts interact to affect how well a catalyst ...
... is a byproduct of nearly all electrical devices and ... aircraft or operating a power plant. Engineering researchers at ... lead to techniques for better capturing and putting this ... marble-sized pellets of the new material are aluminum and ...
... 29, 2011 Today BioSpace , the leading ... Biotech Beach™ Hotbed Campaign, marking the 14th edition. ... organizations across Southern California. Each company,s brand is added ... that is promoted online as well as at industry ...
Cached Biology Technology:Building better catalysts 2Building better catalysts 3Rensselaer engineers 'cook' promising new heat-harvesting nanomaterials in microwave oven 2BioSpace Spotlights Southern California's Life Science Community 2
(Date:8/20/2014)... 20, 2014 George E. Fox, a John and Rebecca ... Houston (UH), was named a fellow in the International Society ... , Fox is one of four members two from ... chosen as fellows in 2014. Fellows are elected every three ... than 500 members from more than 20 countries, the ISSOL ...
(Date:8/20/2014)... 158 pregnant teenagers in Rochester, NY, nearly half engaged ... ice, cornstarch, vacuum dust, baby powder and soap, and ... Moreover, such teens had significantly lower iron levels as ... , Pregnant teens, regardless of pica, are at higher ... deficiency and anemia. Low iron in pregnant teens raises ...
(Date:8/20/2014)... (HCI) at the University of Utah have identified and ... the unregulated enzyme driving the blood cancer chronic myeloid ... 6,000 new cases of CML will be diagnosed in ... inhibitors (TKIs), target BCR-ABL and are effective at controlling ... it in a way that allows patients to get ...
Breaking Biology News(10 mins):UH professor named fellow by International Astrobiology Society 2Pica in pregnant teens linked to low iron 2Blueprint for next generation of chronic myeloid leukemia treatment 2
... COLUMBUS, Ohio Reversing a protein deficiency through gene ... survival in mice that serve as a model for the ... This muscle-wasting disease results when a child,s motor neurons ... muscles produce insufficient amounts of what is called survival ...
... 2010) -- IEEE-USA President Evelyn Hirt praises the Intel-led ... to support investment in U.S.-based technology companies over the ... increase jobs for college graduates. "We commend the ... businesses and for creating high-skill job opportunities for U.S. ...
... The increasing prevalence of type 2 diabetes places a huge ... healthcare systems. Half of all heart attacks and stroke cases, ... the effects of this metabolic syndrome. In Germany alone, some ... number of cases worldwide is projected to reach 370 million ...
Cached Biology News:Study: Gene therapy reverses effects of lethal childhood muscle disorder in mice 2Study: Gene therapy reverses effects of lethal childhood muscle disorder in mice 3Study: Gene therapy reverses effects of lethal childhood muscle disorder in mice 4IEEE-USA President praises US job growth initiative by Invest in America Alliance 2The pig and its pancreas 2The pig and its pancreas 3
Rabbit polyclonal to Presenilin 1, prediluted ( Abpromise for all tested applications). entrezGeneID: 5663 SwissProtID: P49768...
Mouse monoclonal [LPL4A.1] to Plastin L ( Abpromise for all tested applications). SwissProtID: P13796...
... MaV203 Competent Yeast Cells are designed for ... 1). S. cerevisiae strain MaV203 contains deletions ... for use with GAL4-based two-hybrid systems. The ... for selection of ProQuest bait and prey ...
Request Info...
Biology Products: