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Inovio Pharmaceuticals' Prostate Cancer DNA Vaccine Demonstrates Strong T Cell Responses in Monkeys; Company on Track for Phase I Clinical Trial
Date:6/29/2011

e antigens to differ slightly from the native protein. In humans, this novel approach may help the body's immune system to overcome its "self-tolerance" of cancerous cells created in the body by recognizing these cells as being foreign and mounting an immune response to clear these cells.

Inovio is currently manufacturing clinical grade INO-5150 with the goal of launching its planned Phase I study in mid-2012.

Dr. Kim said: "The immune response data achieved by our SynCon™ prostate cancer vaccine in this large animal study is exceptional. It reinforces the repeatedly and consistently strong, long-lasting immune responses achieved by Inovio's DNA vaccine platform against multiple cancers as well as other diseases. We are optimistic about the potential of this therapeutic vaccine in our planned prostate cancer human study and broadly speaking for cancers in general, including our currently progressing cervical cancer and leukemia Phase II clinical studies."

The development of a new treatment for prostate cancer would be a significant medical advance given that present treatment options (surgery, radiation and hormone deprivation), while somewhat effective, all carry deleterious side effects and often do not confer long-term cure. Across the United States, there were 218,000 new cases of prostate cancer and more than 32,000 deaths in 2010.

Inovio's Cancer Portfolio...Into Phase II and Diverse Cancer TypesInovio's SynCon™ DNA vaccine technology has created the potential for a new generation of cancer vaccines. Inovio is moving forward with two DNA vaccines in Phase II development:

  • VGX-3100, Inovio's proprietary DNA vaccine for treating cervical dysplasia and cancer caused by human papillomavirus (HPV); and,
  • pWT1, a DNA vaccine for treating acute and chronic myeloid leukemia (CML and AML). Inovio is also working with partners on this DNA vaccine using its electroporation delivery technology.

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    SOURCE Inovio Pharmaceuticals, Inc.
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