Navigation Links
Inovio Pharmaceuticals' Prostate Cancer DNA Vaccine Demonstrates Strong T Cell Responses in Monkeys; Company on Track for Phase I Clinical Trial
Date:6/29/2011

BLUE BELL, Pa., June 29, 2011 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE Amex: INO), a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today that its therapeutic DNA vaccine for prostate cancer showed remarkable immune responses in monkeys, following similarly strong, antigen-specific and sustainable T cell levels in previously reported data from earlier animal studies. The data was presented by Dr. J. Joseph Kim, Ph.D., president & CEO of Inovio, at the BIO International Convention in Washington, DC. The strength of this new large animal data reinforces Inovio's plan to start a Phase I clinical trial for this prostate cancer DNA vaccine (INO-5150) by mid-year 2012.

In this monkey trial, vaccinations with INO-5150, Inovio's SynCon™ therapeutic DNA vaccine for prostate cancer, generated strong and robust T cell immune responses. The level of T cell responses from this INO-5150 study was similar to the level of T cell responses observed from a previously conducted monkey study of VGX-3100, Inovio's Phase II-stage therapeutic vaccine for cervical cancer and dysplasia. In a Phase I study, VGX-3100 generated best-in-class T cell responses, which were persistent through the complete study duration of nine months.

In a prior study in mice, INO-5150 immunization induced potent antibody and T cell responses, providing initial evidence that its concept for a therapeutic DNA vaccine comprising a broader collection of antigens, administered with Inovio's electroporation-based delivery technology, would improve the breadth and effectiveness of a prostate cancer immunotherapy. Furthermore, the SynCon™ DNA vaccine evaluated in this study was generated by the creation of PSA and PSMA synthetic consensus immunogens based on human and macaque sequences, which enabled the amino acid sequences of th
'/>"/>

SOURCE Inovio Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Inovio Pharmaceuticals to Present at 13th Annual BIO CEO & Investor Conference
2. Inovio Pharmaceuticals Foot-and-Mouth Disease DNA Vaccine Introduces Critical Advantages in Fight Against Most Serious Farm Animal Disease
3. Inovio Pharmaceuticals Enters Phase II Clinical Trial with SynCon™ DNA Vaccine for Cervical Dysplasia Caused by HPV
4. Inovio Pharmaceuticals Reports Long-Term Immune Responses from Therapeutic Cervical Dysplasia and Cancer DNA Vaccine
5. Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2008 Financial Results on Monday, August 11, at 8:30 A.M. EDT
6. ISTA Pharmaceuticals Reports Second Quarter 2008 Financial Results
7. SGX Pharmaceuticals Announces Financial Results for the Three and Six Months Ended June 30, 2008
8. ADVENTRX Pharmaceuticals to Report Second Quarter 2008 Results
9. Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121, an ErbB3 Antagonist
10. VIA Pharmaceuticals to Present at Fourth Annual Noble Financial Equity Conference
11. Anthera Pharmaceuticals Completes $19 Million Financing; Appoints Christopher S. Henney as Chairman
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... , Aug. 20, 2014 Neurotrope, Inc. ... a conference call to provide an update on ... Eastern daylight timeDial-in numbers:(888) 505-4369 (U.S. and Canada) ... web cast: www.neurotropebioscience.com , under "Investor Relations"The teleconference ... completion through September 2, 2014 at (888) 203-1112 ...
(Date:8/20/2014)... 2014 The 6th Annual Arrowhead ... on October 29-30 in San Francisco, CA. This year’s ... government researchers and clinicians focused on addressing and solving ... In the twelve years since the sequencing of the ... introduced with pharmacogenetic information in the label and molecular ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient ... its myPROpad™ ePRO tablet with the addition of a ... most widely used and well-respected Patient Reported Outcome (PRO) ... is used during clinical trials and in other health ... used to demonstrate Health-Related Quality of Life outcomes (HRQoL) ...
(Date:8/19/2014)... 2014 Research and Markets  has announced the addition ... Business Report" report to their offering. This ... in US$ Thousands by the following Product Segments: Media, Sera, and ... US, Canada , Japan , ... Latin America . Annual estimates and forecasts are ...
Breaking Biology Technology:Neurotrope To Host Conference Call 26th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2EQ-5D™ Assessment Now Available for iPad 2Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2
... 27 454 Life Sciences, a Roche,company, in ... have developed a method, using the company,s Genome ... with an,unprecedented level of detail. The new method ... gross changes to the,genetic code in a very ...
... new hires are fruits of strategic plan, ... era of,growth and discovery, Boston Biomedical Research Institute, ... Watertown, MA, has,recruited seven new scientists, a 23% ... newly hired scientists are the fruits of a ...
... Luminex Corporation,(Nasdaq: LMNX ) today announced that ... Forum to be held October 9-11,2007, in San ... Balthrop, president and chief,executive officer, and Harriss T. ... Pacific time; 12:30 p.m. Eastern time on Thursday,October ...
Cached Biology Technology:454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation 2454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation 3New Scientists Boost Disease-based Research at Boston Biomedical Research Institute 2New Scientists Boost Disease-based Research at Boston Biomedical Research Institute 3Luminex Corporation to Present at Biotechnology Industry Organization Investor Forum 2
(Date:8/19/2014)... MA -- MIT chemical engineers have devised a new ... are released slowly over a few weeks. When applied ... the body to rapidly form new bone that looks ... type of coated scaffold could offer a dramatic improvement ... involves transplanting bone from another part of the patient,s ...
(Date:8/19/2014)... Scientists at the Houston Methodist Research Institute have figured ... using a pipette -- a common laboratory tool that,s ... preliminary test results in a recent issue of the ... "Studying single cells and their unique functions has become ... faculty member Lidong Qin, Ph.D., the project,s principal investigator. ...
(Date:8/19/2014)... Science Center at San Antonio and The University of ... of more than $750,000 in grants through the San ... in 2003, SALSI is a model of how a ... center join forces for greater research and graduate education. ... focus on public health issues and diseases of global ...
Breaking Biology News(10 mins):Engineering new bone growth 2Engineering new bone growth 3Moving single cells around -- accurately and cheaply 2San Antonio Life Sciences Institute awards $750,000 to innovators 2San Antonio Life Sciences Institute awards $750,000 to innovators 3
... Monell Chemical Senses Center have succeeded in growing mature taste ... have been able to successfully keep the cells alive for ... long-term model opens a range of new opportunities to increase ... functions in nutrition, health and disease. , "We have an ...
... have sequenced and compared the genomes of planktonic microbes ... The pioneering study yielded insight into the specialization of ... than 13,000 feet. , "By reading the information stored ... begin to measure the pulse of this marine ecosystem," ...
... a piece of real estate may be its most ... the University of California, San Diego (UCSD) and the ... genes and other features distributed along the chromosomes of ... how microbial cells operate. , In a paper published ...
Cached Biology News:Living taste cells produced outside the body 2Living taste cells produced outside the body 3Sequencing our seas 2Sequencing our seas 3Patterns in genome organization may partially explain how microbial cells work 2Patterns in genome organization may partially explain how microbial cells work 3