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Inovio Pharmaceuticals' Prostate Cancer DNA Vaccine Demonstrates Strong T Cell Responses in Monkeys; Company on Track for Phase I Clinical Trial
Date:6/29/2011

BLUE BELL, Pa., June 29, 2011 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE Amex: INO), a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today that its therapeutic DNA vaccine for prostate cancer showed remarkable immune responses in monkeys, following similarly strong, antigen-specific and sustainable T cell levels in previously reported data from earlier animal studies. The data was presented by Dr. J. Joseph Kim, Ph.D., president & CEO of Inovio, at the BIO International Convention in Washington, DC. The strength of this new large animal data reinforces Inovio's plan to start a Phase I clinical trial for this prostate cancer DNA vaccine (INO-5150) by mid-year 2012.

In this monkey trial, vaccinations with INO-5150, Inovio's SynCon™ therapeutic DNA vaccine for prostate cancer, generated strong and robust T cell immune responses. The level of T cell responses from this INO-5150 study was similar to the level of T cell responses observed from a previously conducted monkey study of VGX-3100, Inovio's Phase II-stage therapeutic vaccine for cervical cancer and dysplasia. In a Phase I study, VGX-3100 generated best-in-class T cell responses, which were persistent through the complete study duration of nine months.

In a prior study in mice, INO-5150 immunization induced potent antibody and T cell responses, providing initial evidence that its concept for a therapeutic DNA vaccine comprising a broader collection of antigens, administered with Inovio's electroporation-based delivery technology, would improve the breadth and effectiveness of a prostate cancer immunotherapy. Furthermore, the SynCon™ DNA vaccine evaluated in this study was generated by the creation of PSA and PSMA synthetic consensus immunogens based on human and macaque sequences, which enabled the amino acid sequences of th
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SOURCE Inovio Pharmaceuticals, Inc.
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