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Inovio Pharmaceuticals' Foot-and-Mouth Disease DNA Vaccine Introduces Critical Advantages in Fight Against Most Serious Farm Animal Disease
Date:3/2/2011

cine constructs targeting all seven main FMD virus serotypes, moving from antigen design to large animal testing in only a few months.

In a study conducted in pigs, just a single vaccination with an Inovio FMD vaccine comprising four of the most common FMD serotypes generated high titer, antigen-specific antibody responses for each serotype in the vaccinated animals. The responses were boosted even higher with a second immunization. High levels of T-cell responses were also measured in the vaccinated animals. All vaccines were administered intramuscularly with Inovio's CELLECTRA® electroporation delivery system.

There are several potential advantages of Inovio's FMD DNA vaccine:

  • Inovio's SynCon™ DNA vaccine cannot cause disease, which is a possibility using current killed viral FMD vaccines due to incomplete virus inactivation. This limits current vaccination to herds that may be imminently exposed to FMD. Inovio's vaccine would permit truly preventive vaccination.
  • Inovio's SynCon™ universal vaccine is designed to generate broader, cross-protective immune responses across different FMD serotypes, unlike existing vaccines that must be matched to the FMD serotype.
  • Current FMD vaccines display the same multiple proteins as the actual virus. Healthy vaccinated animals can therefore not be distinguished from infected animals, frequently leading to the slaughter of uninfected herds. Inovio's SynCon vaccine is encoded for a single antigen (VP1 protein) common across FMD serotypes. Because it is a synthetic consensus antigen unmatched to naturally existing FMD strains, a blood test can distinguish non-infected vaccinated animals from naturally infected animals. This could potentially reduce the slaughter of healthy animals in outbreak areas.
  • Better thermal stability of Inovio's product overcomes the challenge of expensive and/or unavailable cold storage and transport in developing countries at high risk of FMD
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  • SOURCE Inovio Pharmaceuticals, Inc.
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