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Inovio Pharmaceuticals' DNA Vaccine for Foot-and-Mouth Disease Generates Protective Neutralizing Antibodies in Second Large-Animal Study
Date:6/30/2011

antly, the multi-subtype DNA vaccines targeting three or four subtypes simultaneously were able to induce equally strong levels of antibody titers compared to the single-subtype vaccines. Strong T-cell responses (cumulatively > 1,500 SFU/million PBMC), which would potentially play a role in treating the disease, were also noted against the four different subtype antigens. Speaking at the meeting, Dr. Sardesai noted, "Encouraged by these results with four subtypes, we are now expanding the coverage of our vaccine to include the three additional key circulating subtypes – SAT 1, 2, 3 – and will initiate further large animal studies to assess breadth of protection."

Dr. J. Joseph Kim, Inovio's president and CEO, said: "We are pleased to demonstrate these robust DNA vaccine immune responses in a second globally-important farm animal impacted by foot-and-mouth disease. FMD pandemics are a worldwide threat to food supply and society, and the limitations of today's FMD vaccines means they are not able to facilitate adequate protection. Inovio's FMD vaccine program could provide a global solution to this menacing threat to our world's food supply. We look forward to further developing this important vaccine."

About Foot-and-Mouth Disease

Foot-and-mouth disease (FMD) affects cloven-hoofed animals such as cattle, pigs, sheep, goats and water buffalo, and is capable of rapidly infecting large numbers of animals. Seven main types of FMD virus are believed to exist today. Like other viruses, the FMD virus continually evolves and mutates. To date there has been no cross-protection between strains even within the different subtypes of the FMD virus. Vaccine viruses which are not completely killed have resulted in FMD outbreaks, hence vaccines used today are administered to the herd only once an outbreak is detected in an area in order to limit the rapid spread of infection, thus limiting the potential utility of such vaccines.

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SOURCE Inovio Pharmaceuticals, Inc.
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