Navigation Links
Injection-free vaccination technique could address global vaccine challenge for HIV, malaria
Date:2/4/2013

ctiveness of the microneedle array, they applied it to mice. Using imaging (in collaboration with Professor Frederic Geissmann, King's College London) they observed how the vaccine dissolved in the skin and were able to identify for the first time exactly which specialised immune cells in the skin 'pick up' this type of vaccine and activate the immune system. The researchers found the first evidence that a sub-set of specialised dendritic cells in the skin were responsible for triggering this immune response.

When compared with a traditional needle vaccine method, the immune response generated by the dried microneedle vaccine (kept at room temperature) was equivalent to that induced by the same dose of injected liquid vaccine that had been preserved at -80C.

Dr Linda Klavinskis from the Peter Gorer Department of Immunobiology at King's College London, said: 'We have shown that it is possible to maintain the effectiveness of a live vaccine by drying it in sugar and applying it to the skin using microneedles a potentially painless alternative to hypodermic needles. We have also uncovered the role of specific cells in the skin which act as a surveillance system, picking up the vaccine by this delivery system and kick-starting the body's immune processes.

'This work opens up the exciting possibility of being able to deliver live vaccines in a global context, without the need for refrigeration. It could potentially reduce the cost of manufacturing and transportation, improve safety (as there would be no loss in potency), and avoids the need of hypodermic needle injection, reducing the risk of transmitting blood-borne disease from contaminated needles and syringes.

'This new technique represents a huge leap forward in overcoming the challenges of delivering a vaccination programme for diseases such as HIV and malaria. But these findings may also have wider implications for other infectious disease vaccination programmes, for example
'/>"/>

Contact: Katherine Barnes
katherine.barnes@kcl.ac.uk
44-207-848-3076
King's College London
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Vaccination reduces the risk of unvaccinated badger cubs testing tuberculosis positive
2. Notre Dame researchers demonstrate new DNA detection technique
3. Research could improve laser-manufacturing technique
4. Clinical technique sets new standard for speed in battle to prevent pandemic infection
5. In new mass-production technique, robotic insects spring to life
6. ResearchMoz: Vaccine Production Market (Trends, Techniques, Key Players, Spending Estimates and Forecasts)
7. Nanosurgery and the fight against cancer: Major breakthrough at Polytechnique Montral
8. Scientists learn how to out run damage with imaging technique
9. New measuring techniques can improve efficiency, safety of nanoparticles
10. Metamaterials may advance with new femtosecond laser technique
11. New imaging technique moves from lab to clinic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 15, 2014 -- According to the International Atomic ... security comes from terrorists acquiring sufficient quantities of ... a crude nuclear explosive device. The IAEA also ... have involved gram-level quantities, which can be challenging ... to a new study appearing this week in ...
(Date:7/10/2014)... basis of psychiatric disorders has been extremely challenging because ... but are insufficient to cause disease. Now investigators reporting ... journal Cell Stem Cell describe a strategy ... interact with other risk factors or environmental exposures to ... pinpoints a genetic variant that may predispose individuals to ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
(Date:1/15/2014)... "The interface is the device," Nobel laureate Herbert ... to be found at the junctures where layers ... of nanotechnology, the interfaces between layers of metal ... such high-tech favorites as spintronics, high-temperature superconductors, ferroelectrics ...
Breaking Biology Technology:Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3A deeper look at interfaces 2
... ANGELES, Feb. 18 The Board of Directors wishes to ... 2009 it resolved to file a Form 15 with effect ... the approval of stockholders but in the interests of keeping ... Release.The effect of this filing is to release the company ...
... SAN DIEGO, Feb. 18 Zogenix, Inc. ("Zogenix"), a ... Drug,Administration (FDA) has provided a target date of July ... for Sumavel DosePro (sumatriptan,injection) needle-free delivery system. Zogenix ... treatment of migraine attacks with or without,aura, and the ...
... Inc. (the "Company") (Nasdaq: PDGI ), a ... biotechnology, generic drug and medical device companies, today announced ... Brazil to further enhance its Latin American presence.PharmaNet has ... 2002 with a network of field-based staff in Brazil, ...
Cached Biology Technology:EESTECH Inc - Release From SEC Filing 2EESTECH Inc - Release From SEC Filing 3EESTECH Inc - Release From SEC Filing 4Zogenix Reports FDA Provides New PDUFA Date for Sumavel(TM) DosePro(TM) 2PharmaNet Development Group, Inc. Expands Latin America Operations with Opening of Brazil Office 2PharmaNet Development Group, Inc. Expands Latin America Operations with Opening of Brazil Office 3PharmaNet Development Group, Inc. Expands Latin America Operations with Opening of Brazil Office 4PharmaNet Development Group, Inc. Expands Latin America Operations with Opening of Brazil Office 5
(Date:7/11/2014)... There is evidence that under the normal ... and development, maintain neuronal environment, and exhibit ... and neurodegenerative disease. Previous studies have found ... cells after chemical induction have reduced viability, ... application. Prof. Xiaodong Yuan, Kailuan General Hospital, ...
(Date:7/11/2014)... Research and Markets has announced the addition ... Analysis Size Share Growth Trends and Forecast to 2019" ... http://photos.prnewswire.com/prnh/20130307/600769 The rising number of ... high level security in both private and public sector. ... and passwords, tokens etc. are vulnerable to attacks. Biometrics ...
(Date:7/11/2014)... of all vertebrates, information is transmitted through synapses, ... signal to be passed from one brain cell ... abundant type of synapse, can be either excitatory ... memory, perception and cognition, and the balance between ... For instance, every time we learn something, ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Blame it on the astrocytes 2
... HILO, HawaiiIn collaboration with Stanford University and ... Service Pacific Southwest Research Station,s Institute of Pacific ... developing "hybrid ecosystems"a mix of native and non-native ... in tropical forests. The research team, comprised ...
... parrots and iguanas may seem inoffensive at first glance when ... escape and become invasive species. This has been confirmed by ... 63 Spanish zoos. Birds are the animals most likely to ... (non-indigenous) species, they could become an entry channel for these ...
... -- Specialized white blood cells called T cells and ... and eliminate "non-self" substances such as viruses and bacteria. ... immunoreceptors on the cell surface bind to specific regions on, ... pathways inside the T cells and B cells that control ...
Cached Biology News:US Forest Service and 2 universities team up to develop new ecosystems for Hawaiian forests 275 percent of Spanish zoos at risk of exotic animals escaping 275 percent of Spanish zoos at risk of exotic animals escaping 3
Recombinant Equine IL-6...
... two highly efficient methods of identifying recombinant ... By using the large-scale screen method in ... is to transfer partial colonies of E. ... into the solutions provided by the kits ...
... Fernandez and G. Butcher (1998). • The ... much research in the immunology area. There ... MHC proteins and in their function as ... faced with the prospect of tackling biochemical ...
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
Biology Products: