Navigation Links
Individual differences caused by shuffled chunks of DNA in the human genome
Date:9/27/2007

enome DNA into manageable-sized pieces about 3000 bases long; tagged and rescued the paired ends of the fragments; and then analyzed their sequence with a high-throughput, rapid-sequencing method developed by 454 Life Sciences.

454 Sequencing can generate hundreds of thousands of long read pairs that are unique within the human genome to quickly and accurately determine genomic variations, explained Michael Egholm, a co-author of the study and vice president of research and development at 454 Life Sciences.

Previous work, based on point mutations estimated that there is a 0.1 percent difference between individuals, while this work points to a level of variation between two- and five-times higher, said Snyder.

We also found hot spots particular regions where there is a lot of variation, said Korbel. While these regions may be still actively undergoing evolution, they are often regions associated with genetic disorder and disease.

These results will have an impact on how people study genetic effects in disease, said Alex Eckehart Urban, a graduate student in Snyders group, and one of the principal authors on the study. It was previously assumed that landmarks, like the SNPs mentioned earlier, were fairly evenly spread out in the genomes of different people. Now, when we are hunting for a disease gene, we have to take into account that structural variations can distort the map and differ between individual patients.

While it may sound like a contradiction, says Snyder, this study supports results we have previously reported about gene regulation as the primary cause of variation. Structural variation of large of spans of the genome will likely alter the regulation of individual genes within those sequences.

According to the authors, even in healthy people, there are variants in which part of a gene is deleted or sequences from two genes are fused together with
'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Age of empowered individuals: People power behind robust computing
2. The Enterprise and the Individual
3. WTN Interview: HHS Secretary calls for $550 million health care fund to reduce deaths caused by medical errors
4. Human Primary Preadipocytes and Differentiated Adipocytes
5. Low Abundance cDNA Cloned Using Stratagenes Human Universal cDNA Library
6. Control RT-PCR Primers for Human Gene Transcripts with Varying Abundance
7. New Mammalian Expression Vectors Employ Stable, High-Level Fluorescence Humanized Renilla GFP Reporter
8. Human Universal cDNA Library Array I
9. Map and Link Human Genetic Disorders with SSLP Analysis
10. RT-PCR Primer Sets for Human and Mouse Mismatch Repair Genes
11. Transfection of Green Fluorescent Protein into Human Adrenalcarcinoma Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 The report “Pharmacy Automation ... Packaging and Labeling Systems, Table-top Counters) by End-user ... Forecasts & Trends to 2019” analyzes and studies ... North America, Europe, Asia-Pacific, and the Rest of ... and 30 figures spread through 300 pages and ...
(Date:10/20/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced four new ... and provides a good start to Q4.  The orders are for ... and one in the Middle East . ... Peter Bruijns , President & CEO. "Total bidding activity and ... have been for any complete year since the company has tracked ...
(Date:10/20/2014)... OncLive® is pleased to ... Thomas Jefferson University has joined its Strategic Alliance ... Partnership program, the Sidney Kimmel Cancer Center at ... of the Center’s cutting-edge research programs, comprehensive approach ... other health care professionals from the Sidney Kimmel ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The 9th ... will take place at the Congress Center ... is now available at http://www.abim.ch . ... organizations from all over the globe will ... latest products and developments on the world ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
... Show on the road. Convinced that American companies are shipping ... 18-city bus tour called Show Us the Jobs . ... Web sites were among the 51 people who toured Wisconsin ... the Bush administration to promote a growing economy. , ,Make ...
... The Sachs-Bloomberg Global Biotech Forum for Investing & ... its forum in Boston, April 1-2. The conference is designed ... companies. , ,The chance to raise venture capital on the ... operating officer at ConjuGon. "I think we're unlike a lot ...
... in my career, dating back as long ago as 1988, ... a lifestyle and joined teams to create magazines to examine ... best - well ahead of our time. , ,Now, many ... and consumer electronics market, the emerging digital lifestyle. This time, ...
Cached Biology Technology:Theres a surprising, and positive, side to the offshore jobs debate 2Theres a surprising, and positive, side to the offshore jobs debate 3Digital Lifestyle: I'm linked in, now what? 2Digital Lifestyle: I'm linked in, now what? 3Digital Lifestyle: I'm linked in, now what? 4
(Date:10/16/2014)... the bowel lining develops and, in the process, suggested ... The researchers produced evidence that stem cells are responsible ... feature of the bowel lining, and believe these stem ... finding as scientists are still divided on the stem ... Wee Tan and Professor Tony Burgess from the Walter ...
(Date:10/16/2014)... 2014 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market ... Wocket™, the Smart Wallet, at the 13 th ... leading global conference on the intersection of technology and ... Anderson , founder and publisher of the Strategic News ...
(Date:10/15/2014)... Gauß-Allianz has admitted Johannes Gutenberg University Mainz (JGU) ... science hub continues to maintain a significant nationwide ... , "The acceptance of Johannes Gutenberg University Mainz ... a milestone in the national and international competition ... state of Rhineland-Palatinate can be proud that Mainz ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... Concern over access to clean water is no ... California faces its worst drought in recorded history. According ... reservoirs and many groundwater basins are well below average. ... the two largest water systems, and an outdated statewide ...
... Researchers at the University of Kentucky Markey Cancer Center ... insight into the genetic mechanisms underlying Huntington,s disease and ... (or TNRs) in DNA. , The research, performed ... of toxicology and biochemistry and the Madeline James & ...
... aren,t made of actin filaments. But their assembly is crucial ... researchers think helps to lay down memories. In the July ... ( www.jcb.org ), Rex et al. reveal that LTP,s ... different pathways, a discovery that helps explain why it is ...
Cached Biology News:Researchers achieve major breakthrough with water desalination system 2Researchers achieve major breakthrough with water desalination system 3Researchers achieve major breakthrough with water desalination system 4Researchers gain insight into mechanism underlying Huntington's 2Building memories with actin 2
Request Info...
Agarose-LE, 500 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
Request Info...
Biology Products: