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Independent Study Corroborates Prana's Strategy to Treat Alzheimer's Disease Patients.
Date:4/1/2009

labe and his colleagues provides an explanation, showing that synaptic activity stimulates the release of Abeta and zinc leading to the build up of toxic Abeta oligomers at the synapse. Previous studies demonstrating that PBT2, can disperse Abeta oligomers attracted by synaptic zinc, suggest that the benefit of PBT2 seen in the recent clinical trial may reflect this synaptic effect".

Professor Colin Masters, Director of the Mental Health Research Institute and Laureate Professor of Medicine at the University of Melbourne, said "these findings provide independent validation that this therapeutic approach is likely to benefit Alzheimer's disease patients by slowing down or delaying the onset of the illness".

The study titled "A role for Synaptic Zinc in Activity-Dependent A(beta) Oligomer Formation and Accumulation at Excitatory Synapses" will be published in the April 1 issue of the Journal of Neuroscience.(1)

(1) Deshpande A, Kawai H, Metherate R, Glabe CG, and Busciglio J. J. Neurosci 2009; 29 (13)

About Prana Biotechnology Limited

Prana Biotechnology was established to commercialise research into Alzheimer's disease and other major age-related neurodegenerative disorders. The Company was incorporated in 1997 and listed on the Australian Stock Exchange in March 2000 and listed on NASDAQ in September 2002. Researchers at prominent international institutions including The University of Melbourne, The Mental Health Research Institute (Melbourne) and Massachusetts General Hospital, a teaching hospital of Harvard Medical School, contributed to the discovery of Prana's technology.

* For further information, and descriptions of the peer-reviewed journals, please visit the Company's web site at www.pranabio.com.

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