Navigation Links
Increased fertility rate for IVF patients achieved by new equipment design

A novel system for processing embryos during IVF treatment has been shown to significantly improve the chances of pregnancy by more than a quarter.

Pioneered by a Newcastle team of fertility experts at the University and within the NHS, the innovative design of interlinked incubators provides a totally enclosed and controlled environment within which every step of the IVF process can be performed.

Research published today in the journal PLoS ONE reveals that the introduction of the new system into the Newcastle Fertility Centre at Life, part of the Newcastle Hospitals NHS Foundation Trust, resulted in a 27% increase in pregnancy rate compared with conventional equipment used in IVF treatment labs.

Traditionally, in IVF procedures embryos are cultured in incubators, which provide a controlled environment. However, it is necessary to check embryo development under the microscope.

This generally involves removing them from the controlled environment of the incubators, which may be harmful. The system developed by the Newcastle team overcomes this problem by enabling all procedures to be conducted within an enclosed and controlled environment.

Initially the new system was tested extensively to make sure that it maintained stable environmental conditions (for air quality and temperature). Subsequent studies on embryos donated to research showed a significant increase in the proportion of embryos developing normally over a period of 6-7 days.

After introduction into the laboratories at Newcastle Fertility Centre at Life, the team were able to compare the treatment outcomes over a period of three years. The study, found that 45% achieved a clinical pregnancy compared to 32% and 35% in each of the preceding two years. This represents a minimum increase of 27% in the clinical pregnancy rate; a clinical pregnancy means that a heart beat was seen on the scan at 7 weeks gestation.

The study, which took account of variability between patients, included women aged 37 or less, undergoing their first cycle of IVF or ICSI, and who had more than ten ovarian follicles (the structures which contain a mature egg).

This is the first and only system of its kind to be installed in the UK, however, based on the innovative design from the Newcastle team, similar systems have already been exported to IVF clinics in the Netherlands, Canada and Thailand.

This positive benefit to IVF patients came from investment into cutting edge research in embryonic stem cell research and was funded by the Medical Research Council and One North East.

Newcastle University's Professor Mary Herbert who led the research team at Newcastle Fertility Centre at Life, part of the Newcastle Hospitals NHS Foundation Trust and based at the Centre for Life, said: "Our aim was to keep eggs and embryos in conditions similar to those they would experience naturally - inside a woman's body. This led our team to design and develop a system in which it is possible to perform all of the technical procedures while maintaining stable conditions throughout the IVF process."

Alison Murdoch, Professor of Reproductive Medicine who leads the clinical service at Newcastle Fertility Centre at Life said: "Growing good embryos is the key to IVF success and everyone, even those who have a very small prospect of success, deserve to have the best possible chance. Since installing this new technology over 850 babies have now been born."


Contact: Karen Bidewell
Newcastle University

Related biology technology :

1. Downsizing and the Need for Increased Selling Effectiveness Fuel Delta Points Growth
2. Amgen’s Third Quarter 2011 Revenue and Adjusted Earnings Per Share (EPS) Each Increased 3 Percent to $3.9 Billion and $1.40
3. Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE
4. Dune Medicals MarginProbe™ Demonstrates Increased Positive Margin Identification Leading to Reduction in Patients Indicated for Re-excision in Landmark Lumpectomy Surgery Trial
5. US Dominance in Scientific Research Significantly Challenged by Increased Competition from Europe and Asia, According to Thomson Reuters Study
6. Proposition 19 Decision Prompts Cannabis Science to Anticipate Increased Demand for its Pharmaceutical Products for Critical Ailments and Begin the Formal Application Process for FDA Clinical Trials Immediately
7. Shire plc: Continued Excellent Performance in Q3, Full Year Earnings Expectations Increased, New Value in Pipeline Emerging
8. Sigma-Aldrich (Nasdaq: SIAL) Reports Q3 2010 Diluted EPS of $0.76. Diluted EPS Increased by 9% and 19% on a Reported and Adjusted Basis, Respectively. Q3 Sales Performance Remains Strong; Full Year 2010 Diluted Adjusted EPS Outlook Raised to $3.20 -
9. Reportlinker Adds Downstream Processing in Biopharmaceuticals - Increased Demand for Biologics Drives Improvement in Cost -effective Purification Technologies
10. Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010
11. Meta-Analysis of SYMLIN(R) Clinical Data Showed No Increased Risk of Cardiovascular Adverse Events Associated With SYMLIN Treatment in Patients With Type 2 Diabetes
Post Your Comments:
(Date:11/24/2015)... - ProMetic Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ("ProMetic" ... , President and Chief Executive Officer of ProMetic, will be ... th Annual Healthcare Conference to be held at the ... st , at 8.50am (ET) and ProMetic,s management team ... presentation will be available live via a webcast accessible at ...
(Date:11/24/2015)... Nev. , Nov. 24, 2015  PDL BioPharma, Inc. ... P. McLaughlin , the company,s president and chief executive officer, ... Healthcare Conference next week in New York City ... occur on Tuesday, December 1, 2015 at 9:30 a.m. EST. ... Please connect to the website at least 15 minutes prior ...
(Date:11/24/2015)... Nov. 24, 2015 According to two new studies, ... This is something that many doctors, scientists, and public health ... remains: with fewer PSA tests being done, will there be ... Dr. David Samadi, "Despite the efforts made in ... the second leading cancer cause of death in men, killing ...
(Date:11/23/2015)... 2015 China Cord Blood Corporation (NYSE: ... of cord blood collection, laboratory testing, hematopoietic stem cell ... preliminary unaudited financial results for the second quarter and ... 2015. --> --> ... for the second quarter of fiscal 2016 increased by ...
Breaking Biology Technology:
(Date:11/9/2015)... , Nov. 9, 2015  Synaptics Inc. (NASDAQ: ... today announced broader entry into the automotive market with ... match the pace of consumer electronics human interface innovation. ... are ideal for the automotive industry and will be ... Europe , Japan ...
(Date:10/29/2015)... , Oct. 29, 2015  The J. Craig Venter ... titled, "DNA Synthesis and Biosecurity: Lessons Learned and Options ... of Health and Human Services guidance for synthetic biology ... --> --> ... has the potential to pose unique biosecurity threats. It ...
(Date:10/29/2015)... , October 29, 2015 ... authentication company focused on the growing mobile commerce ... announces that StackCommerce, a leading marketplace to discover ... the Wocket® smart wallet on StackSocial for this ... ("NXT-ID" or the "Company"), a biometric authentication company ...
Breaking Biology News(10 mins):