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Increased Light Leads to Early Detection: Caliper Life Sciences Introduces Bioware(R) Ultra Cancer Cell Lines
Date:4/15/2008

-Researchers Now Able to Detect a Single Cancer Cell Through In Vivo

Imaging-

HOPKINTON, Mass., April 15 /PRNewswire-FirstCall/ -- Caliper Life Sciences, Inc. (Nasdaq: CALP) today introduced Bioware(R) Ultra cell lines, a range of ultra bright light producing tumor cell lines created specifically for in vivo imaging applications. Bioware Ultra cell lines are 10 to 100 times brighter than cell lines created using traditional methods, which allows researchers, for the first time ever, to detect a single cancer cell in an animal via non-invasive in vivo imaging.

Visualizing and tracking tumor progression in vivo is critical to better understanding how therapeutic treatments impact disease. In vivo imaging provides researchers with the ability to recognize tumor growth and behaviors at the cellular level within living animals. By tagging a tumor with the gene for luciferase, the same gene that allows a firefly to glow, the tumor can produce light that can be monitored using Caliper's highly sensitive IVIS imaging systems. As the disease progresses and reacts to specific compounds, researchers can measure tumor growth and evaluate the efficacy of compounds in real time. This ability to track disease progression in vivo offers a more conclusive understanding of how potential drugs will react in and impact humans.

Increasing the brightness of tumor producing cell lines significantly improves researchers' ability to monitor early tumor behavior and detect micrometastases sooner. Caliper's Bioware Ultra light producing cell lines incorporate the enhanced luc2 gene from Promega. The luc2 gene, an optimized version of luciferase for expression in mammalian cells, creates intensified visible li
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SOURCE Caliper Life Sciences, Inc.
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