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Increased Drug Related Cardiac Toxicity Leads Gwathmey Preclinical Testing Services to Create Novel Cardionomics(TM) Services for Preclinical Cardiac Safety Screening of Drug Candidates
Date:5/8/2008

y available cardiac safety screening expertise and technologies. With this new service, we will design and execute stronger preclinical studies to help eliminate the risk of cardiac safety issues in drugs before they hit the pipeline" said Dr. Judith Gwathmey, President and CSO of Gwathmey Preclinical Testing Services, Inc.
Features of Gwathmey Preclinical's Cardionomics(TM) Services include:

-- Cardiac catheterization

-- Pressure-volume determinations

-- Isolated perfused hearts

-- Telemetry

-- Echocardiography

-- Electrocardiography

-- Isolated muscle studies (animal and human)

-- Human heart failure tissue cDNA array for human pharmacogenomics and

toxicogenomics

These kinds of pre-clinical services on animal models are typically only available in major university settings, which can make easy and immediate access to them difficult.

"Dr. Judith Gwathmey has a record of performing important work in heart failure over several decades. Cardionomics(TM) is an extension of her interest and expertise in this arena. Support for development of highly innovative management strategies will facilitate drug discovery, a needed boost for the field of heart failure," said Gary S. Francis, M.D., Section Head, Clinical Cardiology at the Cleveland Clinic.

Dr. Gwathmey, who conceived this new service concept, is a world-renowned cardiac scientist. She has one of the most cited papers in heart failure research on calcium handling in human myocardium. It has remained in the top fifty most cited papers for over 25 years. Dr. Gwathmey has authored over 160 manuscripts on cardiovascular disease including arrhythmias, cardiac myocyte function, ischemia and global heart function in normal and disease states. She is the author of the highly regarded text book: "Heart Failure: Basic Science and Clinical Medicine," cited by the New England Journal of Medicine.

In support of the new services, Gwat
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SOURCE Gwathmey Preclinical Testing Services, Inc.
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