Navigation Links
In vivo visualization of alternative splicing
Date:1/28/2008

The February 1 cover of G&D features an unprecedented use of fluorescent proteins to visualize developmentally regulated alternative mRNA splicing in a living organism. Dr. Hidehito Kuroyanagi and colleagues at the Tokyo Medical and Dental University engineered a transgenic alternative splicing reporter system to monitor the developmentally regulated switching of let-2 alternative splicing in live C. elegans worms. The splicing of let-2 changes during the lifetime of the worm: Embryos and early larvae express exon 9, while adult worms express exon 10. By linking exons 9 and 10 with differently colored fluorescent proteins (green and red, respectively).

Drs. Kuroyanagi & Hagiwara's team was able to visually monitor let-2 splicing patterns during the life of an individual worm. The reporter system enables experimental analysis of regulation mechanisms underlying the developmental or cell-type-specific profiles of alternative splicing in living organisms. We are coming to realize that the molecular mechanisms of alternative splicing are highly conserved throughout metazoan evolution, explains Dr. Kuroyanagi.


'/>"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

0

GOOD

Page: 1

Related biology technology :

1. Novel Alternative Approach to Inhibiting Insulin Growth Factor (IGF) May Provide New Treatment for Breast Cancer and Other Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... Possible mold re-infestation in Guilemtte School sparked concern among teachers ... posted May 14, 2013, the state is going to inspect ... Cleaning Products offered a tip how to kill mold ... in the Eagle Tribune report (5.14.13) that the fear of ... first-grade classroom was closed due to the high-level of spores ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Clinovo's ... an 8-week training program starting on June 11th, 2013. ... clinical trial professionals reach the next step in their ... Offices in Palo Alto, and streamed online. , Taught ... award-winning papers, Clinovo's new “CDISC Standards: Theory and Application” ...
(Date:5/20/2013)... May 20, 2013  MiMedx Group, Inc. (NASDAQ: ... of patent protected regenerative biomaterials and bioimplants processed from ... a revolving line of credit with Bank of America.  ... by the Company,s accounts receivable and inventory, allows MiMedx ... 2014.  The facility will be used for general corporate ...
(Date:5/20/2013)... Biomarkers and Clinigene International are set to unveil their ... 2013 AAPS/ National Biotechnology Conference May 20-22 ... Marina , San Diego, CA. ... company representatives at their collaborative seminar, "Biosimilarity, Immunogenicity and ... 1-2 p.m. in the conference,s Spinnaker Room. ...
Breaking Biology Technology:Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 2Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 3Clinovo Launches TechTrainings on CDISC Standards 2Pacific Biomarkers and Clinigene International To Announce Laboratory Solutions for Developers of Biosimilars at 2013 AAPS/ National Biotechnology Conference 2
... Top Industry Analyst -, EVANSTON, Ill., Oct. ... industries manage a wide range of sales and ... global management,consulting firm specializing in sales and marketing ... Javelin(TM) Software Suite provides a unified platform for ...
... Pharmasset, Inc.,(Nasdaq: VRUS ) management will ... held from October 13-14, 2008 at the Waldorf ... Medical Officer, will,provide an overview of the company ... About Pharmasset, Pharmasset is a clinical-stage ...
... Facet Solutions, Inc. today,announced the successful completion of ... the lumbar spine by Dr. Vijay Goel,s laboratory ... combination of Facet,Solutions, ACADIA(TM) Facet Replacement System (AFRS(TM)) ... with a,polymeric disc replacement device in a finite ...
Cached Biology Technology:Newly Integrated Software Suite From ZS Associates Offers Comprehensive Set of Sales Performance Management Software Solutions 2Newly Integrated Software Suite From ZS Associates Offers Comprehensive Set of Sales Performance Management Software Solutions 3Facet Solutions Completes Facet Joint and Disc Replacement Study 2
(Date:5/20/2013)... New Geology articles posted online ... cover a wide swath of geoscience subdisciplines, including ... and paleobotany. Locations studied include Siberia; the Sumatran ... Apuane, Italy; Ukraine; Mars; and the Southeastern U.S. ... Rubies, jadeite, and plate tectonics;, 2. The clear ...
(Date:5/18/2013)... 18, 2013) Research presented today at Digestive Disease ... with findings about the impact of coffee on autoimmune ... While coffee consumption recently has been associated with reduced ... a few more cups of java each month also ... disease. Researchers at the Mayo Clinic, Rochester, MN, linked ...
(Date:5/17/2013)... The State University of New Jersey, and City University ... called Visikol TM that effectively clears organisms to ... place of chloral hydrate, which is one of the ... tightly regulated by the Drug Enforcement Administration (DEA) due ... or clearing agents, are vital for viewing organisms under ...
Breaking Biology News(10 mins):New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 2New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 3New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 4New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 5New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 6New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 7New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 8New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 9New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 10New in GEOLOGY: Gems, Darwin, Mars, Hemp, Snowball Earth, a Siberian Impact Crater, and More 11Coffee consumption associated with reduced risk of autoimmune liver disease 2New formula invented for microscope viewing, substitutes for federally controlled drug 2New formula invented for microscope viewing, substitutes for federally controlled drug 3
... computer tools and cryo-electron microscopes, researchers at Baylor College of ... bacteria and, in doing so, opened the door to a ... and animals. , In a report that appears in and ... Nature, Dr. Wah Chiu, professor in the BCM department of ...
... created a new type of 'bio-gel' which provides a pH ... the journal Advanced Materials (March 2006). , The gel is ... (pairs of amino acids) to provide an environment in which ... gel mimics the properties of cell scaffolds which naturally occur ...
... For neurons, overexcitement is deadly. To avoid ... from the synapse through membrane-bound transporters. If ... get excited to death-- a phenomenon that may ... disease. , Indeed, brain deterioration after stroke is ...
Cached Biology News:Unraveling the viral mechanism 2Manchester scientists create new bio-gel for 3D cell culture 2
NATIVE RAT OSTEOCALCIN...
Form: Ready to use Applications: Immunohistology-frozen, Immunohistology-paraffin, Western Blot, ELISA...
Form: Ready to use Applications: ELISA...
EnzChek Ultra Xylanase Assay Kit *500 assays*...
Biology Products: