Navigation Links
In vivo visualization of alternative splicing
Date:1/28/2008

The February 1 cover of G&D features an unprecedented use of fluorescent proteins to visualize developmentally regulated alternative mRNA splicing in a living organism. Dr. Hidehito Kuroyanagi and colleagues at the Tokyo Medical and Dental University engineered a transgenic alternative splicing reporter system to monitor the developmentally regulated switching of let-2 alternative splicing in live C. elegans worms. The splicing of let-2 changes during the lifetime of the worm: Embryos and early larvae express exon 9, while adult worms express exon 10. By linking exons 9 and 10 with differently colored fluorescent proteins (green and red, respectively).

Drs. Kuroyanagi & Hagiwara's team was able to visually monitor let-2 splicing patterns during the life of an individual worm. The reporter system enables experimental analysis of regulation mechanisms underlying the developmental or cell-type-specific profiles of alternative splicing in living organisms. We are coming to realize that the molecular mechanisms of alternative splicing are highly conserved throughout metazoan evolution, explains Dr. Kuroyanagi.


'/>"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1

Related biology technology :

1. Novel Alternative Approach to Inhibiting Insulin Growth Factor (IGF) May Provide New Treatment for Breast Cancer and Other Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/14/2017)... Oregon (PRWEB) , ... August 14, 2017 , ... ... that provide essential device-to-computer interconnect using USB or PCI Express, announced the release ... , SYZYGY is intended to satisfy the need for a compact, low cost, ...
(Date:8/11/2017)... , Aug. 11, 2017  Market researcher ... York Times article regarding the telemedicine market.  ... to Kalorama Information.  The article, "Heart ... That"  used information from Kalorama Information,s ... & Telemedicine Market  (Sleep, Diabetes, Vital ...
(Date:8/11/2017)... ... 11, 2017 , ... Algenist continues to disrupt the skincare industry with today’s ... , Collagen is the key structural element skin needs to maintain its youthful ... , First to market with proprietary collagen water active ...
(Date:8/10/2017)... , ... August 09, 2017 , ... ... help the agriculture industry reach its ideal customers with the right message. Their ... , “As a Midwest company, we realize how crucial the agriculture industry is,” ...
Breaking Biology Technology:
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/24/2017)... , Mar 24, 2017 Research and Markets ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 15.1% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
Breaking Biology News(10 mins):