Navigation Links
Improved culture system for hepatitis C virus infection
Date:7/15/2008

A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the Hepatitis C virus (HCV) and provide a realistic environment to evaluate possible treatments. The novel cell line, described in the July 16 issue of PLoS ONE, will allow pharmaceutical companies to effectively test new drug candidates or possible vaccines for the HCV infection, which afflicts about 170 million people worldwide. Currently, there is no animal model that is effective for testing such therapies.

Assistant Professor of Medicine Martina Buck, Ph.D., researcher at UC San Diego's Department of Medicine and Moores UCSD Cancer Center developed the novel culture system, which mimics the biology of HCV infection in humans.

"This is the first efficient and consistent model system for HCV to be developed," said Buck, adding that it will now enable researchers not only to conduct mechanistic experiments in culture, such as blocking the virus pathways, but also to more effectively screen possible therapies for HCV. "There is a need for new treatments, and for development of a possible vaccine for HCV. Now we have a model system to support work by investigators in this area."

Currently, there is only a single treatment for HCV, PEG- interferon-α. The drug combination has an average response rate of about 50 percent in HCV cases, but it is much lower than that, closer to 20 percent, in individuals with liver cirrhosis. It can also cause severe flu-like side effects. Approximately 10,000 deaths due to cirrhosis of the liver and several thousand more from liver cancer are attributed to HCV infection in the United States each year.

The HCV life cycle is only partially understood because, until now, it has not been possible to efficiently infect normal human hepatocytes, or liver cells, in culture. According to Buck, the valuable Huh-7 system
'/>"/>

Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Oridion Launches its Fully Integrated Remote Monitoring System and SARA Software for Improved Patient Safety
2. Varian Medical Systems Introduces New and Improved VariSeed(TM) 8.0 Software for Permanent Seed Prostate Brachytherapy Treatments
3. Novo Nordisk Increased Operating Profit by 11% in the First Nine Months of 2007 Based on a 9% Sales Increase and an Improved Gross Margin
4. Improved wettability of carbon nanotubes opens the door to new possibilities
5. Diagnostic Turnaround Improved by 600% Through Interoperability
6. Taxotere(R)-Based Chemotherapy Significantly Improved Overall Survival Compared With Standard Anthracycline-Based Chemotherapy in Early Stage Breast Cancer
7. New Robotic Imaging Technology Holds Promise of Improved Cancer Care
8. Improved governance needed to realize nanotechs benefits
9. Sophisticated soil analysis for improved land use
10. China Kangtai Cactus Biotech Announces Improved Milk Production in Cows From Companys Cactus Cattle Feed
11. Phase 3 studies show golimumab significantly improved signs and symptoms of rheumatoid arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Village, Calif. (PRWEB) January 15, 2014 ... treatment and management through the genomic analysis of tumor ... offer Therapy Finder™, a web-based cancer decision support application ... reporting option with Cynvenio’s ClearID™ genomic test, Therapy Finder ...
(Date:1/15/2014)... Toronto, Canada (PRWEB) January 15, 2014 ... perspectives on nonclinical and clinical safety assessment in biosimilars. ... a path for biosimilar drug development, however the complex ... regards to quality, safety and efficacy extremely challenging. Based ...
(Date:1/15/2014)... 15, 2014 Two champions of science, ... sponsorship of an annual competition for middle and high ... to, innovative STEM study. The competition presents students with ... of Engineering Aptitude, Mathematics, and Sciences is a ...
(Date:1/15/2014)... 2013 was a banner year of continued ... saw continued independent research led by the team at ... $1 million grant from the Susanne Marcus Collins Foundation, ... peer reviewed journal, Amy Grant highlighted Brainwave Optimization® in ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Inc. (NTI(R)) (Nasdaq: NTII ), today announced ... GmbH (Merz) for sales,by Merz and its marketing ... disease for the quarter ended September 30,2007. Under ... payments on sales of Memantine by Merz and ...
... improved but still flawed government-wide plan for nanotechnology ... system. Federally-funded studies essential to managing possible ... by a top-down strategy tied to projected commercialization, ... decision-making process. , The National Nanotechnology ...
... collaboration between researchers at the National Institute of Standards ... Kentucky potentially offers a low-cost way to mass produce ... for a wide range of applications including flexible displays, ... field diagnostics. , In a paper posted this week,* ...
Cached Biology Technology:Neurobiological Technologies Reports $2.1 Million Quarterly Payment for Sales of Memantine 2Federal nanotech risk research plan still comes up short 2Directed self-ordering of organic molecules for electronic devices 2
(Date:7/9/2014)... common frog is one of the amphibians with the ... in permanent areas of water where it comes into ... its larvae. Research carried out by the Spaniard Germn ... the larvae of these frogs have developed a defensive ... tails and larger bodies if they co-exist with the ...
(Date:7/9/2014)... measurement results accrue. To completely and systematically archive ... In fact, researchers in the life sciences spend ... to an online survey of 70 people working ... for Applied Information Technology FIT in Sankt Augustin. ... no centralized or structured approach to data collection ...
(Date:7/9/2014)... inhibitors and N-methyl-D-aspartate receptor antagonists can alleviate ... to affect irreversible cognitive dysfunction and effectively ... Amyloid beta peptide (Aβ) vaccines reduced and ... (AD) transgenic mouse model, and significantly improved ... and his team, First Affiliated Hospital of ...
Breaking Biology News(10 mins):Frogs have developed rapid defences against the red swamp crayfish 2Frogs have developed rapid defences against the red swamp crayfish 3Managing the data jungle 2Managing the data jungle 3
... of vertebrate species, but while groups such as mammals, birds ... decades, knowledge about relationships among many types of fishes was ... of scientists led by Richard Broughton, associate professor of biology ... of Oklahoma, published two studies that dramatically increase understanding of ...
... proportion of black carbon created during combustion will remain in ... burying black carbon in the ground in order to restrain ... a part of black carbon will dissolve from soil to ... to the ocean was estimated in a research article published ...
... the University of Birmingham, BGI and its open-access ... the UK,s Natural Environment Research Council (NERC) to ... large-scale environmental metabolomics data. Metabolomics involves the ... living organisms and can provide an indication of ...
Cached Biology News:Something's fishy in the tree of life 2'Black carbon' flowing from soil to oceans 2Collaboration to establish new computational resources for metabolomics 2
RABBIT ANTI HUMAN TRRAP (CT) Immunogen: Recombinant C-terminal kinase-related domain of human TRRAP....
RABBIT ANTI HUMAN CHYMOTRYPSIN...
MSE ANTI CAN. CD3:FITC/RAT ANTI CD4:RPE...
MOUSE ANTI POLY (ADP-RIBOSE) Immunogen: Purified poly (ADP-ribose) polymer, 10-50 unit chain length...
Biology Products: