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Important Step Forward in Osteoarthritis Research: Bioactive Collagen Peptides Stimulate the Regeneration of Cartilage Tissue
Date:9/14/2009

gs about an increase in proteoglycan. Previously, the Harvard/Tufts clinical trial had proved the regenerative effect of FORTIGEL(R) on the knee-joint cartilage using an objective imaging technique. These two investigations complement each other.

The double-blinded, placebo-controlled Harvard/Tufts trial involved 30 patients diagnosed with osteoarthritis of the knee and revealed a significant regeneration of the cartilage tissue in the FORTIGEL(R) group. In the placebo group cartilage degeneration progressed as before.

To analyze the structural changes in the cartilage tissue the Harvard/Tufts researchers deployed a special imaging technique (dGEMRIC). Following the injection of a special dye into the patient's knee joint it is possible to determine the proteoglycan density in the cartilage with a high degree of accuracy. The results of this clinical trial indicate a significant increase in proteoglycan after the application of FORTIGEL(R). This delivers clinical confirmation for the experimental findings of the CRI.

Treatment of osteoarthritis

"The targeted manipulation of the cartilage metabolism opens up new possibilities for the treatment and prevention of osteoarthritis," emphasizes Dr. Oesser. Unlike analgesic and antirheumatic drugs, which merely alleviate the symptoms and effects, FORTIGEL(R) now offers the potential for an alimentary, causal therapy.

Worldwide approximately 135 million people suffer from osteoarthritis. Experts predict a rapid rise in this figure - above all in the industrialized nations. The prevention of arthritic diseases enjoys top priority, due not least to the high costs incurred by the healthcare systems.

Based in Kiel/Germany, the Collagen Research Institute (CRI) was established in 2003 as an independent research organization. The institute's activities centre on
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SOURCE Collagen Research Institute
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