Navigation Links
Important Step Forward in Osteoarthritis Research: Bioactive Collagen Peptides Stimulate the Regeneration of Cartilage Tissue

MONTREAL and KIEL, Germany, September 14 /PRNewswire/ -- Working in collaboration with Kiel University, researchers at the Kiel- based Collagen Research Institute (CRI) have demonstrated the stimulating effect of special bioactive collagen peptides (FORTIGEL(R)) in the context of cell experiments. Last weekend the CRI presented its research findings at the congress of the Osteoarthritis Research Society International (OARSI) in Montreal. The investigations of the CRI provide an explanation for the findings of a joint clinical trial carried out by Harvard Medical School and Tufts Medical Center - likewise presented at the congress. With the aid of special imaging (MRI) techniques this clinical trial demonstrated that FORTIGEL(R) stimulated cell metabolism in the knee-joint cartilage and promotes the regeneration of cartilage tissue.

In cooperation with Kiel University the CRI researchers applied molecular-biology and protein-chemistry analysis methods directly to the cells in order to demonstrate the stimulating effect of FORTIGEL(R). Developed by GELITA AG, this product contains a special combination of high-purity bioactive collagen peptides. "In our investigations we showed that - alongside the synthesis of Type II collagen - FORTIGEL(R) induces the increased production of aggrecan, a special proteoglycan which is of central importance to the cartilage function," explains Dr. Steffen Oesser, Director of the CRI. This provides experimental proof that the application of bioactive collagen peptides stimulates the renewed synthesis of the extracellular cartilage matrix.

Cell experiment underpins the Harvard/Tufts clinical study

The cell-based experiments of the CRI confirm the findings of a clinical trial conducted by the Harvard Medical School and the Tufts Medical Center. The CRI has clearly demonstrated at the cellular level that FORTIGEL(R) brings about an increase in proteoglycan. Previously, the Harvard/Tufts clinical trial had proved the regenerative effect of FORTIGEL(R) on the knee-joint cartilage using an objective imaging technique. These two investigations complement each other.

The double-blinded, placebo-controlled Harvard/Tufts trial involved 30 patients diagnosed with osteoarthritis of the knee and revealed a significant regeneration of the cartilage tissue in the FORTIGEL(R) group. In the placebo group cartilage degeneration progressed as before.

To analyze the structural changes in the cartilage tissue the Harvard/Tufts researchers deployed a special imaging technique (dGEMRIC). Following the injection of a special dye into the patient's knee joint it is possible to determine the proteoglycan density in the cartilage with a high degree of accuracy. The results of this clinical trial indicate a significant increase in proteoglycan after the application of FORTIGEL(R). This delivers clinical confirmation for the experimental findings of the CRI.

Treatment of osteoarthritis

"The targeted manipulation of the cartilage metabolism opens up new possibilities for the treatment and prevention of osteoarthritis," emphasizes Dr. Oesser. Unlike analgesic and antirheumatic drugs, which merely alleviate the symptoms and effects, FORTIGEL(R) now offers the potential for an alimentary, causal therapy.

Worldwide approximately 135 million people suffer from osteoarthritis. Experts predict a rapid rise in this figure - above all in the industrialized nations. The prevention of arthritic diseases enjoys top priority, due not least to the high costs incurred by the healthcare systems.

Based in Kiel/Germany, the Collagen Research Institute (CRI) was established in 2003 as an independent research organization. The institute's activities centre on degenerative changes to the connective tissue and the development of complementary and alternative therapies in the area of osteoarthritis, osteoporosis and wound healing. Since its establishment CRI has devoted special attention to investigating the effects of collagen peptides on the extracellular matrix of the articular cartilage.

    Collagen Research Institute

    Dr. Steffen Oesser
    Tel. +49-(0)431-56-06-610
    Fax  +49-(0)431-56-06-613

SOURCE Collagen Research Institute
Copyright©2009 PR Newswire.
All rights reserved

Related biology technology :

1. Cephalon Reinforces Important Prescribing and Dosing Information for FENTORA
2. 454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation
3. Stem Cell Science Holds Opportunities as Important Tool for Diabetes Research Beyond Cell-Based Treatments
4. Oregon Health Care Quality Corporation Receives Important Designation from U.S. Department of Health and Human Services
5. Off-Label Stent Use: How Important Are FDA Approvals to Physicians?
6. AMT Makes Important Advance in the Development of its Gene Therapy for Hemophilia B -Company Accesses Technology to Prevent Immune Response
7. Silence Obtains Important Patent Protection for Lead Internal Development Compound, Atu027
8. Mymetics Corporation Important Shareholders Information Conference Call
9. Ukrainian President Yushchenko: Pharmaceuticals Very Important
10. Fifth DuraHeart(TM) U.S. Implant Marks Important Milestone in U.S. Pivotal Trial
11. Bavarian Nordic Receives USD 25 Million Milestone Payment After Submission of Important IMVAMUNE(R) Data to The U.S. Health Authorities
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... Cancer experts ... they believe could be a new and helpful biomarker for malignant pleural mesothelioma. ... here to read it now. , Biomarkers are components in the blood, ...
(Date:6/27/2016)... NC (PRWEB) , ... June 27, 2016 , ... ... mission to bring innovative medical technologies, services and solutions to the healthcare market. ... and implementation of various distribution, manufacturing, sales and marketing strategies that are necessary ...
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... announced the funding of a Sponsored Research Agreement ... circulating tumor cells (CTCs) from cancer patients.  The ... in CTC levels correlate with clinical outcomes in ... These data will then be employed to support ...
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
Breaking Biology Technology:
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
Breaking Biology News(10 mins):