Navigation Links
Implanted neurons, grown in the lab, take charge of brain circuitry
Date:11/21/2011

aved.

A critical tool that allowed the UW group to answer this question was a new technology known as optogenetics, where light, instead of electric current, is used to stimulate the activity of the neurons.

"Previously, we've been limited in how efficiently we could stimulate transplanted cells. Now we have a tool that allows us to specifically stimulate only the transplanted human cells, and lots of them at once in a non-invasive way," says Weick.

Weick explains that the capacity to modulate the implanted cells was a necessary step in determining the function of implanted cells because previous technologies were too imprecise and unreliable to accurately determine what transplanted neurons were doing.

Embryonic stem cells, and the closely related induced pluripotent stem cells can give rise to all of the 220 types of tissues in the human body, and have been directed in the lab to become many types of cells, including brain cells.

The appeal of human embryonic stem cells and induced pluripotent cells is the potential to manufacture limitless supplies of healthy, specialized cells to replace diseased or damaged cells. Brain disorders such as Parkinson's disease and amyotrophic lateral sclerosis, more widely known as Lou Gehrig's disease, are conditions that scientists think may be alleviated by using healthy lab grown cells to replace faulty ones. Multiple studies over the past decade have shown that both embryonic stem cells and induced cells can alleviate deficits of these disorders in animal models.

The new study opens the door to the potential for clinicians to deploy light-based stimulation technology to manipulate transplanted tissue and cells. "The marriage between stem cells and optogenetics has the potential to assist in the treatment of a number of debilitating neurodegenerative disorders," notes Su-Chun Zhang, a UW-Madison professor of neuroscience and an author of the new PNAS report. "You can imagin
'/>"/>

Contact: Jason P. Weick
weick@wisc.edu
608-262-8969
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Implanted glucose sensor works for more than 1 year
2. Gem of an idea: A flexible diamond-studded electrode implanted for life
3. Laboratory-grown urethras implanted in patients, scientists report
4. New method for producing precursor of neurons, bone and other important tissues from stem cells
5. Ions control shape of nanofibers grown on clear substrate
6. Carbon molecule with a charge could be tomorrows semiconductor
7. Lilly to Take Charge to Earnings Related to Pending Federal and State Investigations of Past Practices
8. T-System Releases The T SystemEV(R) 2.6.3, Featuring New Meds/Allergies Notification, Automated Charge Capture
9. A supercharged metal-ion generator
10. Boston Scientific Resolves Outstanding Litigation Matter, Finalizes Goodwill Impairment Charge
11. Authentidate Teams with Nortel to Enhance Hospital Patient Discharge and Placement Processes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... More than 5 million Americans are currently ... seniors will die with Alzheimer’s or another dementia, according ... shocked many Americans into looking for ways to improve ... age-related cognitive disorders. Jonathan Weisman, president of Biohack Pure, ...
(Date:1/15/2014)... Freeslate, Inc ., the leading ... Lupin Limited, one of India’s top five pharmaceutical companies, ... System for high throughput solid form screening. ... a wide range of quality, affordable generic and branded ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company ... under simulated embryonic conditions, today announced that they have ... Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent ... is an amendment to the existing license between Histogen ...
(Date:1/14/2014)... SAN DIEGO and BETHESDA, Md. ... they are joining together with two institutes from the ... more reliable tools for bringing safer, more effective treatments ... with the National Center for Advancing Translational Sciences (NCATS) ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... firm , Brookfield, Wis. Norlight ... the customer base and business assets of the Michigan-based ... to give Norlights product range, including hosted IP telephony ... Rapids and Lansing regions. , Criticare purchasing orders for ...
... CIO of American Family When Byrne Chapman started his ... he imagined. Yet the business needs at American Family Insurance ... has started handling terabytes of storm data from the national ... paths and match the predictions to the locations of their ...
... gadget guys and girls this is your time. The shops ... season. But when it comes to the value of these devices ... them. I guess I fall into the latter category. , ... (although when I read the Unabombers manifesto several years ago a ...
Cached Biology Technology:American Family CIO takes entrepreneurial approach to innovation 2American Family CIO takes entrepreneurial approach to innovation 3American Family CIO takes entrepreneurial approach to innovation 4More electronic gadgets, more miscommunication 2More electronic gadgets, more miscommunication 3
(Date:4/23/2014)... Huntington,s disease, most in their mid-thirties and forties, ... behavioral decline within two decades. "Mutant" protein clusters, ... disease, have been the primary focus of therapies ... new research from Prof. Gerardo Lederkremer and Dr. ... Cell Research and Immunology, in collaboration with Prof. ...
(Date:4/23/2014)... evidence that the source of a unique rhythmic sound, ... the "bio-duck," is the Antarctic minke whale ( Balaenoptera ... in the 1960s who thought it sounded like a ... locations in the Southern Ocean, but its source has ... an international team of researchers deployed acoustic tags on ...
(Date:4/23/2014)... The shale gas boom has transformed the energy ... locations, it could cause conflict among the energy ... resources, say researchers. They add that degraded water ... adequate safeguards. The feature article appears in the ... , Meagan S. Mauter and colleagues point out ...
Breaking Biology News(10 mins):On the defensive 2On the defensive 3Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3How to avoid water wars between 'fracking' industry and residents 2
... University of Pittsburgh,s Department of Biological Sciences to encourage ... been rewarded with two prestigious grants totaling $2 million ... as the renewed appointment of department chair and Eberly ... Professors nationwide and the only one in Pennsylvania. ...
... in plots to blow up the London subway, among other ... planned to pack some of his bombs with toxic gas. ... his accomplices before they could carry out their attacks. ... failed, at some point someone might succeed. The right ...
... from a shrub called the burning bush, known for ... in biofuels and low-calorie food oils, according to Michigan ... applied to seeds of the species Euonymus alatus -- ... the gene responsible for its manufacture of a novel, ...
Cached Biology News:Pitt's education of aspiring undergrad, high school biologists rewarded with $2 million 2'Scrubbing' chemical-contaminated buildings clean with lasers 2'Scrubbing' chemical-contaminated buildings clean with lasers 3Research promises healthier vegetable oil -- and tractor fuel to harvest it 2
Request Info...
Purified Mouse anti-Hu LAT (pY226) Storage Temperature: Refrigerate(2 to 8C)...
Molecular Biology grade. Ideally suited for DNA and RNA separation and recovery. High gel strength. Gelling temp. 36C. Melting temp. 88C. EEO: 0.05-0.13 Resolution 0.2-40 kb; Rnase/Dnase: none detec...
...
Biology Products: