Navigation Links
Implanted neurons, grown in the lab, take charge of brain circuitry
Date:11/21/2011

MADISON -- Among the many hurdles to be cleared before human embryonic stem cells can achieve their therapeutic potential is determining whether or not transplanted cells can functionally integrate into target organs or tissues.

Writing today (Monday, Nov. 21) in the Proceedings of the National Academy of Sciences, a team of Wisconsin scientists reports that neurons, forged in the lab from blank slate human embryonic stem cells and implanted into the brains of mice, can successfully fuse with the brain's wiring and both send and receive signals.

Neurons are specialized, impulse conducting cells that are the most elementary functional unit of the central nervous system. The 100 billion or so neurons in the human brain are constantly sending and receiving the signals that govern everything from walking and talking to thinking. The work represents a crucial step toward deploying customized cells to repair damaged or diseased brains, the most complex human organ.

"The big question was can these cells integrate in a functional way," says Jason P. Weick, the lead author of the new study and a staff scientist at the University of Wisconsin-Madison's Waisman Center. "We show for the first time that these transplanted cells can both listen and talk to surrounding neurons of the adult brain."

The Wisconsin team tested the ability of their lab grown neurons to integrate into the brain's circuitry by transplanting the cells into the adult mouse hippocampus, a well-studied region of the brain that plays a key role in processing memory and spatial navigation. The capacity of the cells to integrate was observed in live tissue taken from the animals that received the cell transplants.

Weick and colleagues also reported that the human neurons adopted the rhythmic firing behavior of many brain cells talking to one another in unison. And, perhaps more importantly, that the human cells could modify the way the neural network beh
'/>"/>

Contact: Jason P. Weick
weick@wisc.edu
608-262-8969
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Implanted glucose sensor works for more than 1 year
2. Gem of an idea: A flexible diamond-studded electrode implanted for life
3. Laboratory-grown urethras implanted in patients, scientists report
4. New method for producing precursor of neurons, bone and other important tissues from stem cells
5. Ions control shape of nanofibers grown on clear substrate
6. Carbon molecule with a charge could be tomorrows semiconductor
7. Lilly to Take Charge to Earnings Related to Pending Federal and State Investigations of Past Practices
8. T-System Releases The T SystemEV(R) 2.6.3, Featuring New Meds/Allergies Notification, Automated Charge Capture
9. A supercharged metal-ion generator
10. Boston Scientific Resolves Outstanding Litigation Matter, Finalizes Goodwill Impairment Charge
11. Authentidate Teams with Nortel to Enhance Hospital Patient Discharge and Placement Processes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... OR and Hershey, PA (PRWEB) December 19, 2014 ... Pink: BJCT), a leading developer and manufacturer of ... entered into an agreement with Immunomic Therapeutics, Inc. ... Biojector®-2000 needle-free injection device with its LAMP™ vaccine ... an option for an exclusive Worldwide license to ...
(Date:12/19/2014)... MA (PRWEB) December 19, 2014 Charm ... MRLAFMQ test for the Detection of Aflatoxin M1 in ... to receive independent third party validation. The peer reviewed ... Unit of the Institute for Agricultural and Fisheries Research ... Group. , Aflatoxin B1, the most toxic aflatoxin ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), ... promotion of Nick Maroulis, Pharm.D. to the newly created ... , In this position, Dr. Maroulis will continue to ... directors of our multi-site pharmacies as the company expands. ... during that time he has served in many different ...
(Date:12/19/2014)... EVANSTON, Ill. , Dec. 19, 2014 ... to develop novel drugs for diseases of the central ... Ph.D., president and chief executive officer, will present at ... Dr. Riedel,s presentation will take place at 3:00 p.m. ... St. Francis in San Francisco, Calif. ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... non-profit arm the SBC Foundation, has given $285,500 in ... Milwaukee has reported. , ,Twenty-four organizations that ... received money to help them use more technology. The ... which typically gives from $2,500 to $25,000 per organization. ...
... secretary of Wisconsins Department of Commerce, said on Friday that he ... partner in the law firm Quarles & Bradys Milwaukee office. , ... two years. He will be returning to the firm he worked ... deal from Governor Doyle as a leader, a boss, and a ...
... Having judged last years a success, the Wisconsin ... the second annual Wisconsin Governor's Business Plan Contest ... businesses will submit 250-word business proposals within one of ... business services. The proposals will be accepted until January ...
Cached Biology Technology:Secretary Nettles leaving Commerce for law practice 2Secretary Nettles leaving Commerce for law practice 3Governors business-plan competition starts another round 2Governors business-plan competition starts another round 3
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/8kmfcn/iphone_5s ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... July 2012, Apple introduced the fingerprint reading feature ... only device of Apple incorporating such a feature, ...
(Date:12/19/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... North America Perimeter Security Systems Market" report to ... The North American perimeter security market is ... 2014 to 2019. Although the U.S. market holds a ... is expected to grow at a higher CAGR ...
(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the leading ... study that pinpoints fine-scale differences in genetic ancestry of ... . Since immigrants first arrived more than ... has served as a meeting place for ... history and the ongoing mixing of peoples with African, ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 323andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... , Sept. 4, 2013  Rapid growth in microRNA (miRNA) ... its diagnostic and therapeutic potential, has fuelled development ... Of the various miRNA technologies, which include quantitative ... functional tools, qRT PCR remains the fastest-growing, while ...
... . Families of thousands of victims of ... appropriate punishment, because of a suite of technologies able ... graves, perhaps hundreds of thousands remain undiscovered. Researchers at ... Ridge National Laboratory are developing a method to discover ...
... pleased to announce that the 2014 HFSP Nakasone Award ... Institute of Science for his pioneering work in discovering ... single most important foundation of the field of systems ... of genetic circuits to systematic analysis and understanding. ...
Cached Biology News:Frost & Sullivan: Diagnostic and Therapeutic Potential of microRNAs Stimulate Need for More Research Tools 2Frost & Sullivan: Diagnostic and Therapeutic Potential of microRNAs Stimulate Need for More Research Tools 3Frost & Sullivan: Diagnostic and Therapeutic Potential of microRNAs Stimulate Need for More Research Tools 4September 2013 story tips 2September 2013 story tips 3The 2014 HFSP Nakasone Award goes to Uri Alon 2
... The SPD101B is a no-frills, basic SpeedVac ... Although economically priced, this unit still features ... a digitial display of time and heat. ... samples and accepts a wide variety of ...
Digital display of time, vacuum and temperature , Dual vacuum control of ramping rate and ultimate level , Comes complete with RH40-12 (40 x 1.5 ml) Rotor and (2) Glass Condensation Flasks. ...
... The DNA120 is a dedicated concentrator for ... precipitates of DNA/RNA. The integrated system combines ... pump. The compact design, automatic pump and ... run time; one for heater time), makes ...
For absolute protein quantification. 4 peptides in 5 vials x 2 nmol per peptide...
Biology Products: