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Implantable slimming aid
Date:11/26/2013

s Fussenegger. The animals ate less because the implant signalised a feeling of satiety to them. Mice that received normal animal feed with a five-per-cent fat content did not lose any weight or reduce their intake of food, says the biotechnologist.

Sensor for different dietary fats

One major advantage of the new synthetic regulatory circuit is the fact that it is not only able to measure one sort of fat, but rather several saturated and un-saturated animal and vegetable fats that are ingested with food at once. How-ever, this development cannot simply be transferred to humans. It will take many years to develop a suitable product. Nonetheless, Fussenegger can certainly envisage that one day obese people with a body mass index of way over thirty could have such a gene network implanted to help them lose weight. Fussenegger sees the development as a possible alternative to surgical inter-ventions such as liposuction or gastric bands. "The advantage of our implant would be that it can be used without such invasive interventions." Another merit: instead of intervening in the progression of a disease that is difficult to regulate, it has a preventive effect and exploits the natural human satiety mechanism.

This gene network is one of the most complex that Fussenegger and his team have constructed to date and was made possible thanks to the biotechnologist's years of experience in the field. It is not the first time he and his team have suc-ceeded in constructing such a complex feedback regulatory circuit: a number of years ago, they produced an implant that can also be used to combat gout via a feedback regulatory circuit.


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Contact: Martin Fussenegger
martin.fussenegger@bsse.ethz.ch
41-613-873-160
ETH Zurich
Source:Eurekalert  

Page: 1 2

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