Navigation Links
Immune system protein starves 'staph' bacteria
Date:2/14/2008

One of the ways we defend ourselves against bacterial foes is to hide their food, particularly the metals they crave. A multi-disciplinary team led by Vanderbilt University investigators has now discovered that a protein inside certain immune system cells blocks the growth of staph bacteria by sopping up manganese and zinc.

The findings, reported Feb. 15 in Science, support the notion that binding metals to starve bacteria is a viable therapeutic option for treating localized bacterial infections. New treatment strategies are urgently needed to combat the surging number of infections and deaths caused by antibiotic-resistant forms of Staphylococcus aureus (staph), such as MRSA.

If recent estimates are accurate, the number of deaths caused by MRSA exceeds the number of deaths attributable to HIV/AIDS in the United States.

Staph is arguably the most important bacterial pathogen impacting the public health of Americans, said Eric Skaar, Ph.D., assistant professor of Microbiology and Immunology and senior author of the study.

Staph is the leading cause of pus-forming skin and soft tissue infections, the leading cause of infectious heart disease, the number one hospital-acquired infection, and one of four leading causes of food-borne illness.

And it seems as if complete and total antibiotic resistance of the organism is inevitable at this point, Skaar said.

The dire outlook motivates Skaar and his colleagues in their search for new antibiotic targets.

Skaar and Brian Corbin, Ph.D., postdoctoral fellow and lead author of the report in Science, reasoned that proteins present at the site of a staph infection might be important to the battle between the bug and the immune system, and might therefore make good targets for therapeutics. They took advantage of the fact that staph forms abscesses pimple-like infected areas in internal organs like the liver.

Because we can tell exactly where the infection is
'/>"/>

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. MedImmune Strengthens Key Leadership Functions to Further Support Recently Expanded, Rapidly Advancing Product Portfolio
2. MedImmune Submits Biologics License Application to FDA for Motavizumab
3. Peptimmune Announces First Close of Series D Private Financing
4. MedImmune Broadens Focus of Venture Capital Fund to Include New Therapeutic Areas
5. QED International Associates Announces Changes to the HealthShares(TM) Autoimmune-Inflammation and Neuroscience Indexes - Correction
6. QED International Associates Announces Changes to the HealthShares(TM) Autoimmune-Inflammation and Neuroscience Indexes
7. MedImmune Announces Seven Key Promotions and New Hires
8. AstraZeneca Bolsters Its Worldwide Biologics Division Through Integration of Cambridge Antibody Technology Into MedImmune
9. MedImmune to Present RSV Surveillance and Cost-Effectiveness Data at American Academy of Pediatrics National Conference & Exhibition
10. MedImmune Recognized by Local Volunteer Organization for Its Employees Exceptional Commitment to Community Service within Montgomery County
11. Advanced Immune Support Formula Licensed From UC Berkeley Launched
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... N.Y. , June 30, 2015  Custom Computer ... announced today that they are silver sponsors of the ... official PCDC sponsor, Custom is lending their support of ... low-income communities. Since its founding in 1993, ... the primary care area.  PCDC has financed over 100 ...
(Date:6/30/2015)... IL (PRWEB) , ... June 30, 2015 , ... ... effective August 14. She has accepted the position of vice president of instruction ... August 17. , “I greatly appreciated the opportunity to lead SIUE during ...
(Date:6/29/2015)... ... June 30, 2015 , ... This cutting edge standard making ... Featuring 12 distinct peaks, the WAV-8 is the world’s first cuvette-shaped, solid-state filter ... deep into the NIR range. Previous spectrophotometer calibration standards, such as those made from ...
(Date:6/29/2015)... ... 2015 , ... The global microfluidics market is expected to ... to 2020). The market is mainly driven by the rising geriatric population, growing ... lack of adequate healthcare and research infrastructure in emerging markets, dearth of skilled ...
Breaking Biology Technology:Custom Computer Specialists Announces Sponsorship Of The Primary Care Development Corporation's Corporate Circle 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 2SIUE’s Furst-Bowe Accepts VP of Instruction at CVTC 3FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 2FireflySci Releases Spectrophotometer Calibration Standards for NIR Wavelength Accuracy Verification 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5
... , SAN DIEGO , July 20 Volcano Corporation ... therapy guidance tools designed to enhance the diagnosis and treatment of coronary ... results for the second quarter and first six months of fiscal 2010 ... , , ...
... , July 19 Univfy, a pioneer in ... prognostic tools, announced today the publication of new research findings ... Sciences ( PNAS ) by its founding scientific team ... paper details their development of the first rigorously validated prognostic ...
... 19 "Amira Pharmaceuticals, Inc. announced today that its FLAP ... milestones." , , , ... the successful progression of the program to Phase 2 studies, which explore the ... , , , ...
Cached Biology Technology:Volcano Corporation Schedules Second Quarter Conference Call, Webcast 2Univfy and Stanford Scientists Develop the First Personalized Prognostic Test to Predict Live Birth Outcomes with In Vitro Fertilization 2Univfy and Stanford Scientists Develop the First Personalized Prognostic Test to Predict Live Birth Outcomes with In Vitro Fertilization 3Univfy and Stanford Scientists Develop the First Personalized Prognostic Test to Predict Live Birth Outcomes with In Vitro Fertilization 4Amira Pharmaceuticals Hits Two Development Milestones Related to FLAP Inhibitor Program 2
(Date:6/30/2015)... June 30, 2015 Genisphere announced ... CEO to help further develop Genisphere,s therapeutics capabilities and ... experience, having spent much of the last 25 years ... Baxter Bioscience, and Johnson & Johnson. Tom started his ... and Biotech Corporate Finance. He graduated from Dartmouth College ...
(Date:6/25/2015)... , June 25, 2015  Imagine a tool ... toward a healthier, happier life. That,s exactly what USANA,s ... to do. The cutting-edge, portable health program provides a ... solutions to help improve your lifestyle and nutrition. ... dinner and gala Wednesday night, USANA,s THA was honored ...
(Date:6/24/2015)... SAN JOSE, Calif. , June 24, 2015 ... leading developer of human interface solutions, today announced ... fingerprint sensor to provide secure authentication for its ... Having recently reached more than 200 million shipments ... shipment with Sharp reinforces Synaptics, strength, scalability and ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2
... reporting evidence that certain ingredients in shampoo, detergents and ... precursor materials for formation of a suspected cancer-causing contaminant ... plants. The study sheds new light on possible environmental ... which is of ongoing concern to health officials. Their ...
... Elsevier, the world-leading provider of scientific, technical and ... initiative for the Chinese market which involves the establishment ... Center School of Distance Learning for Medical Education (PUHSC). ... affiliated to PUHSC and Elsevier, signed an agreement today ...
... bacteria counts, in more than 70 percent of bottled ... United States Pharmacopeia (USP). Researchers from Ccrest laboratories ... of the American Society for Microbiology in San Diego. ... number of urban Canadians are switching over to bottled ...
Cached Biology News:Elsevier and Peking University Health Science Center develop new China online CME service 2Study finds high level of bacteria in bottled water in Canada 2
... which belong to the transforming growth ... is a large group of extra-cellular ... of development, reproductive function and tumor ... bone morphogenetic proteins, growth differentiation factors, ...
... be able to handle larger sample volumes, automate ... as interface with telemetry systems. The AccuSampler ... dogs, pigs, and primates. The system may ... the computer can be located outside the animal ...
... laboratories working in a regulated environment, ... pipette calibration software that automates gravimetric ... a framework that meets todays regulatory ... a secure solution that includes a ...
... Vtg in plasma from juvenile or male fish ... disrupting chemicals (EDCs) with estrogenic effects in fish. ... test for the estrogenic effects of EDCs in ... a double-antibody immunometric (sandwich) EIA for analyzing Vtg ...
Biology Products: