Navigation Links
Immune cell discovery could help to halt cancer spread
Date:8/14/2014

testines, mucous membranes and skin to detect and destroy diseased cells. However these predatory natural killer cells are a double-edged sword.

Dr Huntington said the team showed natural killer cells also played a role in death from toxic shock (sepsis), and in rejecting bone marrow transplants.

"Natural killer cells led the response that caused rejection of donor stem cells in bone marrow transplantations," Dr Huntington said. "They also produced inflammatory signals that can result in toxic shock syndrome, a potentially fatal illness caused by bacterial toxins that causes a whole-body inflammatory reaction."

Dr Huntington said the discovery provided a solid lead to look for ways of boosting natural killer cells when they are needed in higher supply, or depleting them when they are causing illness.

"We showed MCL-1 levels inside the cell increase in response to a blood cell signalling protein called interleukin 15 (IL-15). We previously knew IL-15 boosted production and survival of natural killer cells, and we have shown that IL-15 does this by initiating a cascade of signals that tell the natural killer cell to produce MCL-1 to keep it alive."

"Now that we know the critical importance of MCL-1 in the survival of natural killer cells, we are investigating how we might manipulate this protein, or other proteins in the pathway, to treat disease," Dr Huntington said.


'/>"/>

Contact: Liz Williams
williams@wehi.edu.au
61-428-034-089
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. MedImmune Announces Winners of Its 6th Annual Global Abstract Competition
2. Immune Design Corp. Appoints Wayne R. Gombotz, Ph.D. as Chief Development Officer
3. MU researchers identify key plant immune response in fight against bacteria
4. Argos Therapeutic Arcelis™ Immunotherapy AGS-003 in Combination With Sunitinib Shows Statistically Significant Correlation of Immune System Response to Overall Survival in Phase 2 Study in Patients with Advanced Renal Cell Carcinoma (RCC)
5. Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach
6. IGY Immune Technology & Life Sciences Purchases Manufacturing Facility to Produce Purified Immunoglobulin Y (IgY)
7. Immune Deficiency Foundation Urges FDA To Exempt Immunoglobulin From Biosimilars Pathway
8. Peer-reviewed Article Reports ProImmune's Immune Formulation 200® Activates the Immune-Support Gene Nrf2.
9. Genalyte Launches Maverick ENA Kits For Fast, Easy And Accurate Multiplexed Autoimmune Testing
10. AllCells Introduces Autoimmune Diseased Cells and Tissue Products
11. Novel Cancer Immune Therapy Developer Oncos Therapeutics Appoints Experienced Industry Leader Frans Wuite as President and CEO
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune cell discovery could help to halt cancer spread
(Date:11/26/2014)... 25, 2014 Miles Holder, formerly of ... Graphel Carbon Products team as Sales/Marketing Manager. Mr. Holder ... customer service for the graphite industry. , “We are ... team,” stated Dave Trinkley, VP of Market and Product ... of experience in the graphite industry, along with his ...
(Date:11/26/2014)... N.J. and WILMINGTON, DE (PRWEB) November 26, 2014 ... 2nd Annual MPN Heroes recognition reception on December 5, ... of Hematology’s annual meeting. The MPN Heroes event will ... contributions in the field of myeloproliferative neoplasms (MPNs). ... show "Nashville," will discuss his family's cancer journey at ...
(Date:11/26/2014)... Theravalues Corporation est fier d,annoncer le lancement de ... Hi Europe 2014 (du 2 au 4 décembre à ... la plus biodisponible actuellement sur le marché, elle ... approuvés par les règlements européens. La ... racine de curcuma ( Curcuma longa ) qui ...
(Date:11/26/2014)... 25 novembre 2014 /PRNewswrie/ -- Theravalues Corporation annuncia con ... europeo in occasione di Hi Europe 2014 (dal 2 ... Si tratta della curcumina con la maggiore biodisponibilità ... cristalli) e ingredienti approvati dalle norme europee. ... della pianta curcumina ( Curcuma longa ) che è ...
Breaking Biology Technology:Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... year, and I have talked less about music this year than ... is bring back more music (hopefully something blue, rock, or folk-related). ... to as many concerts this past year, or bought many new ... 2006, my focus has been more on biotech's international side and ...
... get the first spot on Google , Yahoo ... was the highest bid. Today, even the experts aren't sure ... continue to update their pay-per click (PPC) infrastructures to increase ... ranking for ads promoting link farms and other sites without ...
... Madison, Wis. - The nation's space agency announced this month ... long enough to pack for the longer trip to Mars ... should bypass the Earth's lifeless satellite and head directly ... Still others say the government should get out of the business ...
Cached Biology Technology:2006: A great biotech financing year, unless you were going public! 22006: A great biotech financing year, unless you were going public! 32006: A great biotech financing year, unless you were going public! 42006: A great biotech financing year, unless you were going public! 5It takes more than money to reach the top 2It takes more than money to reach the top 3It takes more than money to reach the top 4Flying to the moon? Take Wisconsin tech along 2Flying to the moon? Take Wisconsin tech along 3Flying to the moon? Take Wisconsin tech along 4
(Date:11/7/2014)... conjunction with the Glendale and ... the Verdugos has announced the " GLENDALE - ... to keep the Verdugo Regional Crime Lab operational after its ... existence, the Lab has processed more than 400 DNA samples, ... "Because our number one priority is the wellbeing of ...
(Date:11/6/2014)... occur because of metastasis, yet progress in preventing ... , "It,s been particularly challenging to design drugs ... fellow in systems biology at Harvard Medical School. ... after they,ve already metastasized." , Gujral and colleagues ... help researchers better understand how metastasis begins. Their ...
(Date:11/5/2014)... Fidel Santamaria, associate professor of biology in the ... researchers in the nation selected to receive a ... Grant for Exploratory Research (EAGER). The funding supports ... support researchers to create new technology that will ... Santamaria, complex behaviors in neuroscience are broken into ...
Breaking Biology News(10 mins):Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Migration negation 2Migration negation 3UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... 2008, 1:00 p.m. ET) Research published in Nature Chemical ... death pathway, termed necroptosis, all target and inhibit RIP1 ... Induced by trauma such as a heart attack or ... tissue damage contributing to death or long-term disability. The ...
... In a bid to significantly boost our understanding of ... (UEA) and the Lowestoft-based Centre for Environment, Fisheries & ... The alliance will strengthen existing collaboration between the ... research. The pressures of global climate change on the ...
... (11 April) at the UK National Stem Cell Network ... bone stem cells may be harnessed to repair the ... of osteoarthritis. Scientists at Cardiff University have successfully ... although it cannot become any cell in the body ...
Cached Biology News:Stopping unwanted cell death: Implications for drug discovery 2Stopping unwanted cell death: Implications for drug discovery 3New UEA-Cefas alliance launched 2Stem cells offer cartilage repair hope for arthritis sufferers 2
...
...
... This antibody recognizes murine IRF7 ... with other related IRF proteins. ... murine IRF7 protein was confirmed ... the 293T cells transfected with ...
...
Biology Products: