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Immune Function in Adult Heart Transplant Patients Reflects Risk for Organ Rejection and Infection
Date:4/11/2008

(average CMI = 438 ng/mL ATP) than the average measure among patients showing no signs of rejection (average CMI = 301 ng/mL ATP; p = 0.05).

The analysis also looked at the incidence of infections among the study population. A total of 30 infections were identified in patients with low CMI (<225 ng/mL ATP; based on 57 assays) as compared to only eight infections in patients with moderate or strong CMI (>225 ng/mL ATP; based on 113 assays). The average CMI in samples from patients with infection was 119 ng/mL ATP as compared to 336 ng/mL ATP in samples from patients with no sign of infection (p < 0.001). Identified infections included 13 with a viral etiology; 15 with bacterial etiology; and 10 with fungal etiology.

"Immune function monitoring of adult heart transplant patients using the ImmuKnow assay may have the potential to aid in the assessment of the immune status of the patient and the patient's risk for organ rejection or infection," concluded Dr. Kobashigawa. "We are currently conducting clinical studies using these data to manage immunosuppression in our heart transplant patients, with the goal of limiting risk for rejection and infection."

Dr. Kobashigawa's presentation was entitled, "Success of immune monitoring with ImmuKnow (Cylex(TM)) to assess rejection/infectious risk in heart transplantation." Dr. Kobashigawa is Clinical Professor of Medicine and Chief of the Division of Clinical Faculty Medicine at David Geffen School of Medicine at UCLA. He is also Medical Director of the UCLA Heart Transplant Program.

About ImmuKnow(R)

ImmuKnow is an immune cell function assay that can detect cell-mediated immunity (CMI) in adult immunosuppressed patients by measuring the concentration of adenosine triphosphate (ATP) released from CD4 cells following cell stimulation.

The ImmuKnow test is a qualitative assay and does not directly quantify the level of immunosuppression. Results of ImmuKnow assays should be used in conjunc
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SOURCE Cylex Inc.
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