Navigation Links
Image of new antibiotic in action opens up new opportunities to combat antibacterial resistance
Date:8/4/2010

Detailed pictures published today reveal how a new type of experimental antibiotic can kill bacteria that are already resistant to existing treatments [1]. The findings could ultimately help scientists to develop new antibiotics to tackle the bacteria responsible for many hospital and community-acquired infections.

Using an imaging technique called x-ray crystallography, a team of researchers from GlaxoSmithKline (GSK) captured a snapshot of the new compound latched on to the enzyme topoisomerase. This enzyme is part of the bacteria's internal machinery and helps the bacteria produce proteins and replicate. Stopping this enzyme prevents the bacteria from reproducing. Medicines, known as the quinolones, that target the enzyme have been used successfully as antibiotics since 1962, however bacteria are increasingly developing resistance to this class of drugs.

By looking at x-ray images, the team have demonstrated that the new investigational medicine attaches to the enzyme in a different place to the quinolones, enabling it to stop the same bacteria that are resistant to these older treatments. The research is published today in the journal Nature, and is the result of two unique collaborations between GSK and the Wellcome Trust's Seeding Drug Discovery initiative and the U.S. Defense Threat Reduction Agency (DTRA).

"We already knew that targeting this enzyme was clinically proven to stop bacteria in their tracks, we just needed to be a bit more inventive in how we attacked it," said Michael Gwynn, from GSK's Infectious Diseases research group. "These images and the data showing the efficacy of this compound against a range of bacteria validate our approach, demonstrating that the enzyme can still be blocked even in bacteria already resistant to other antibiotics that work against this same enzyme."

The study also reports the potency of the new compound, called GSK 299423, against antibiotic-resistant strains of bacte
'/>"/>

Contact: Jen Middleton
j.middleton@wellcome.ac.uk
44-207-611-7262
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Repligen Announces FDA and EMA Approval of Re-analysis of Images from Phase 3 Trial of RG1068 for Pancreatic Imaging
2. Physicists capture first images of atomic spin
3. Caliper Life Sciences Launches Living Image(R) 4.0 Software
4. Imagenetix to Present at 2nd Annual LD MICRO Conference at the Luxe Sunset Bel Air
5. Imagenetix, Inc. to Present at the 2009 RedChip New York Equities Conference
6. First Spaceborne Hyperspectral Imager Will Use QImaging Rolera-MGi EMCCD Camera
7. Imagenetix, Inc. Announces Interview With Bloomberg Radio
8. Boston University Periodontal Study on Imagenetix Compound Published in The Journal of Periodontology
9. Imagenetix, Inc. Reports First Quarter 2010 Results
10. Powerful Image Registration and Recognition Software Unveiled for Medical, Satellite, and Defense Imaging Industries
11. ChemImage Works to Improve Existing Methods of Imaging Untreated Fingerprints on Paper Substrates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... BROOK, NY (PRWEB) July 30, 2014 ... APDN), (Twitter: @APDN), a biotechnology firm that provides DNA-based ... Michael E. Hogan, Ph.D. Vice President of Life Sciences, ... mid-September. , Dr. Hogan will lead APDN’s ... form business relationships with biotech and healthcare customers, provide ...
(Date:7/30/2014)... SAN DIEGO , July 30, 2014  Orexigen ... it has received the Day 180 List of Outstanding ... Medicinal Products for Human Use (CHMP) for the NB32 ... / bupropion SR) is an investigational drug candidate being ... of the earlier Day 120 time point were adequately ...
(Date:7/30/2014)... IRVINE, Calif. , July 30, 2014 /PRNewswire/ ... on the research and development of compounds to ... in humans, today announces that its partner, CardioNova, ... Phase 1b clinical trial with AtheroNova,s lead compound, ... continuation of the AHRO-001 Phase 1 safety trial ...
(Date:7/30/2014)... 2014 Vala Sciences was recently ... Protection Agency (EPA). This new contract was awarded ... including tests designed to assess the effect of ... of connections between neurons (synapses), which are critical ... formation by environmental pollutants likely contributes to a ...
Breaking Biology Technology:Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 2Dr. Michael E. Hogan, Ph.D., Joins Applied DNA Sciences as Vice President, Life Sciences 3Orexigen Receives CHMP Day 180 List of Outstanding Issues 2Orexigen Receives CHMP Day 180 List of Outstanding Issues 3AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 2AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 3AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 4U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 2U.S. Environmental Protection Agency (EPA) Awards Vala Sciences a Second ToxCast Contract 3
... 6 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical,Inc. ("China Sky ... ), a leading,fully integrated pharmaceutical company producing over-the-counter drugs ... appointment of Mr.,William Wei Lee as an independent member ... 4, 2009. Mr. Jiang Qi-Feng resigned from the,Board effective ...
... Aug. 6 /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: ... focused on endocrine therapy and oncology, today announced that ... a corporate overview at the upcoming Canaccord Adams 29th ... at 2:00 p.m. (eastern time) at the Intercontinental Hotel ...
... WALTHAM, Mass., Aug. 6 Repligen Corporation (Nasdaq: RGEN ... ended June 30, 2009. Total revenue for the quarter was ... of fiscal year 2009. The prior year results were favorably ... for royalties on the U.S. sales of Orencia(R) prior to the ...
Cached Biology Technology:China Sky One Medical, Inc. Appoints New Independent Director 2China Sky One Medical, Inc. Appoints New Independent Director 3Repligen Reports First Quarter Fiscal Year 2010 Financial Results 2Repligen Reports First Quarter Fiscal Year 2010 Financial Results 3Repligen Reports First Quarter Fiscal Year 2010 Financial Results 4Repligen Reports First Quarter Fiscal Year 2010 Financial Results 5Repligen Reports First Quarter Fiscal Year 2010 Financial Results 6Repligen Reports First Quarter Fiscal Year 2010 Financial Results 7
(Date:7/30/2014)... distance between two points is a straight line, and ... taking the familiar axiom to heart. , Though ... intense, with each racing for the chance to fertilize ... form cooperative groups that allow them to take a ... study, conducted by Heidi Fisher, a post-doctoral student working ...
(Date:7/30/2014)... joint venture between The University of Texas at San ... Center at San Antonio, has selected the winners of ... from UTSA and Lei Huang from the Health Science ... engineered ferritins for tracking and protecting neural stem cells ... focused on finding a treatment for stroke through stem ...
(Date:7/30/2014)... of $1 million from the Cornelia Cogswell Rossi Foundation ... Center. , The newly established Connie Cogswell ... develop a greater breadth and depth of knowledge of ... pace of research to improve human health. , The ... the Laboratory and its external partners, supporting research to ...
Breaking Biology News(10 mins):When cooperation counts 2When cooperation counts 3Rossi Foundation pledges $1M for JAX neurobehavioral research center 2
... Development Research Centre (IDRC) together with the Canadian Institutes ... Research Council of Canada (NSERC), and the Social Sciences ... that five research teams have been awarded a total ... on Adaptation to Climate Change (IRIACC). ...
... programs -- one involving traditional health club sessions and the ... similar amounts of weight and body fat, but the online ... them live healthier and leaner lives. "It,s counter-intuitive, ... but the activities that they do in a virtual world ...
... male bird called a golden-collared manakin performs a difficult, ... scientists report that female golden-collared manakins select mates based ... "The male jumps like he,s been ... Schlinger, professor and departmental chair of integrative biology and ...
Cached Biology News:International research initiative on adaptation to climate change announces research awards 2International research initiative on adaptation to climate change announces research awards 3ACSM: Weight loss success in a 3-D virtual world 2Again, but faster! The spectacular courtship dance of a tiny bird 2Again, but faster! The spectacular courtship dance of a tiny bird 3
Anti-human CD48/BLAST-1, clone MEM102, Monoclonal Antibody...
Recognizes Kir4.1. The epitope does not share homology with any other known proteins.,SPECIES REACTIVITIES: The antibody is also expected to work with mouse and human due to sequence homology. Oth...
Mouse Anti-Amyloid beta [1-16], clone 6E10, Monoclonal Antibody...
Immunogen: Synthetic peptide: N(171) H G F L S A D Q QL I K(183) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: