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IVF Thanksgiving: Reproductive Science Center Marks 25th Anniversary
Date:11/25/2013

CSI), a laboratory procedure that isolates and injects one sperm into an egg, resulting in a high likelihood of fertilization and embryo development. Considered one of the sentinel achievements in reproductive technology, ICSI has revolutionized the treatment of male factor infertility.

In 1996, Reproductive Science Center physicians and embryologists achieved pregnancy for a couple challenged by a previously untreatable form of male factor infertility known as azoospermia, in which the man has no sperm in his ejaculate. The RSC doctors were able to use sperm, which had previously been frozen after being surgically retrieved from the man’s testicles. Using ICSI, his testicular sperm was injected into eggs retrieved from his wife. Embryos developed, leading to a successful pregnancy and live birth of a healthy baby.

In addition to ICSI, RSC was also an early adopter of Preimplantation Genetic Diagnostic testing (PGD), and more specifically “microarray” technology that affords a much higher sensitivity for genetic mutation detection or chromosome copy number determination in embryos. RSC Science and Laboratory Director Kathryn Go, PhD explains that, “The evolution of these methods is critically important in all areas of medicine and is widely applied to understand the differences between healthy and diseased cells and tissues.”

The 1990s also marked the emergence of “third party reproduction” -- the use of egg donors and gestational surrogates. These were critical in expanding services to older infertile women especially, as well as women who could not gestate (carry a pregnancy). IVF using egg donors and gestational carriers has also revolutionized the ability for male couples to have genetically related children. The Reproductive Science Center’s Medical Director, Samuel Pang, MD, was the first Reproductive Endocrinologist in New England to facilitate IVF for a gay male couple in 1998. Dr. Pang has also pioneered “Reciprocal IVF” for female
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