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ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results
Date:11/3/2009

9% QD confirmatory clinical study and are working diligently to file a supplemental New Drug Application (sNDA) in 2009. Our rich late-stage pipeline includes a new low-dose formulation of bromfenac for dry eye, which is expected to enter Phase 3 studies during the first half of 2010, and bepotastine nasal spray, both of which represent even larger market opportunities than ocular allergy. We are confident in our core products and in our ability to grow our business even further over the coming years as we launch new products."

                                   Net Revenue
                      (in millions, except percentage data)

                 Three Months Three Months       Nine Months Nine Months
                    Ended        Ended              Ended      Ended
                  September    September     %    September  September   %
                  30, 2009     30, 2008   Change  30, 2009   30, 2008  Change

    Xibrom         $21.4        $16.2       32%     $55.1      $41.6     32%
    Istalol          5.1          3.9       31%      13.0        9.5     37%
    Vitrase          1.4          1.5       -7%       4.0        3.7      8%
    Bepreve          1.2          0.0        -        1.2        0.0      -
    Total product   29.1         21.6       35%      73.3       54.8     34%
    Other            2.9          0.1        -        3.1        0.2      -
    Total          $32.0        $21.7       47%     $76.4      $55.0     39%

Third Quarter and Year to Date Operating Details

Net revenue for the three and nine months ended September 30, 2009 was $32.0 and $76.4 million, respectively, or an increase of 47% and 39%, respectively, over the same periods of 2008. Included in net revenue for the three and nine months in 2009 is $1.2 million associated with the launch of Bepreve and $2.9 million of previously deferred revenue associated with the termination of a supply agreement.

Gross margin for the
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SOURCE ISTA Pharmaceuticals, Inc.
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