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INFORM-1 Interim Results Accepted for Late-Breaker Presentation at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL)
Date:3/18/2009

dose we've explored in the clinic to date and the dose of R7128 is only one-half the dose currently being studied in the clinic, we look forward to presenting the results of subsequent higher dose cohorts of INFORM-1."

INFORM-1 Study Design

The following information regarding the INFORM-1 study is available on www.clinicaltrials.gov:

  • Patients in Cohort A are dosed in two groups, Group A and Group B. Patients in Group A receive 500mg BID of R7128 as monotherapy for three days followed by four days of combination therapy comprised of the same dose of R7128 plus 100mg q8h of ITMN-191. Patients in Group B receive 100mg q8h of ITMN-191 as monotherapy for three days followed by four days of combination therapy comprised of the same dose of ITMN-191 plus 500mg BID of R7128.
  • Patients in Cohort B receive the same doses of R7128 and ITMN-191 as patients in both groups of Cohort A, but for a full 14 days in combination. Cohort B is referred to as Group C in the EASL abstract.
  • Patients in Cohort C are dosed in two groups, Group D and Group E. Patients in Group D receive 1000 mg BID of R7128 and 100mg q8h of ITMN-191 for 14 days. Patients in Group E receive 500 mg BID of R7128 and 200 mg q8h of ITMN-191 for 14 days.
  • Patients in Cohort D are dosed in one Group (Group F) and receive 1000 mg BID of R7128 and 200 mg of ITMN-191 q8h for 14 days.

About EASL

The European Association for the Study of the Liver (EASL) is the leading European association in the field of liver research. EASL brings together clinicians and scientists interested in the liver, providing an outlet for networking and learning. The EASL Annual Meeting attracts more than 7,000 participants annually.

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