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IFRS Information - First Half of 2007
Date:9/13/2007

N/A

DAYTRANA 31.8 - N/A N/A

GI

PENTASA 84.0 62.6 +34 +6

LIALDA 5.0 - N/A N/A

RENAL

FOSRENOL 47.3 13.9 N/A +12

DYNEPO 1.9 - N/A N/A

1.1.1.1.6GP

CALCICHEW 25.6 22.1 +16 N/A

CARBATROL 33.4 30.3 +10 -5

REMINYL/REMINYL XL 14.6 9.3 +57 N/A

XAGRID 31.6 26.2 +21 N/A

Other product

sales 52.6 57.8 -9

__________ __________ __________

832.0 667.9 +25

__________ __________ __________

Human Genetic

Therapies

REPLAGAL 64.4 54.1 +19 N/A

ELAPRASE 69.3 - N/A N/A

__________ __________ __________

133.7 54.1 N/A

__________ __________ __________

Total product sales

965.7 722.0 +34

__________ __________ __________

The following discussion includes references to prescription and market share data for Shire's key products. The source of this data is IMS Health, June 2007. IMS Health is a leading global provider of business intelligence for the pharmaceutical and healthcare industries.

ADDERALL XR

ADDERALL XR is the leading brand in the US ADHD market with an average market share of 26% during the six months to June 30, 2007 (2006: 26%). US ADHD market growth of
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SOURCE Shire plc
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