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IFRS Information - First Half of 2007
Date:9/13/2007

e dimesylate)

XAGRID(R) (anagrelide hydrochloride)

The following are trade marks of third parties referred to in this filing.

3TC (trademark of GlaxoSmithKline ("GSK"))

DYNEPO (trademark of Sanofi-Aventis)

JUVISTA (trademark of Renovo)

PENTASA (trademark of Ferring)

RAZADYNE (trademark of Johnson & Johnson)

REMINYL (trademark of Johnson & Johnson, excluding UK and Republic of

Ireland)

SEASONIQUE (trademark of Barr Laboratories, Inc.)

ZEFFIX (trademark of GSK)

SHIRE PLC

RESULTS OF OPERATIONS FOR THE SIX MONTHS TO JUNE 30, 2007 AND

2006 UNDER IFRS

Total revenues

The following table provides an analysis of Shire's total revenues by

source:

6 months to 6 months to

June 30, June 30,

2007 2006 Change

$'M $'M %

Product sales 965.7 722.0 +34

Royalties 123.5 121.4 +2

Other 13.9 6.7 +107

Total 1,103.1 850.1 +30

Product sales

The following table provides an analysis of Shire's key product sales:

6 months to 6 months to US

June 30, June 30, Product sales prescription

growth growth

2007 2006

$'M $'M % %

Specialty

Pharmaceuticals

ADHD

ADDERALL XR 504.2 426.8 +18 +7

ADDERALL - 18.9 N/A
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SOURCE Shire plc
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