Navigation Links
IBM Scientists Use Lab-on-a-Chip Nanochannel Technology Designed to "Stretch" DNA to Help Detect Disease
Date:5/15/2017

ARMONK, N.Y., May 15, 2017 /PRNewswire/ -- IBM (NYSE: IBM) scientists have developed a "lab-on-a-chip" technology that can stretch double-stranded DNA molecules with the potential to efficiently reveal biomarkers that may indicate disease.

This technology complements the IBM Research's "lab-on-a-chip" nanoDLD technology which separates bioparticles, such as exosomes and which may also contain biomarkers for disease detection. The nanochannel technology, which uses an array of diamond shaped micropillars1 to pre-stretch DNA from its coiled state, before being pushed through the chip's nanochannels, could allow medical professionals to detect the presence of genomic alterations in the DNA molecules.

DNA Stretching Video: https://www.youtube.com/watch?v=cQPMzc5n_4Q 

Caption: Fluorescent microscopy video of lambda-DNA molecules (~48,000 base pairs in length and labelled with a fluorescence dye), as they stretch, before they get linearized when they translocate through nanochannels of a width of 200 nm.

Scientists have discovered2 that certain genetic alterations, such as fusions of different parts of DNA, or an unusual amplification of the number of copies of certain genes, or a simple change in the DNA sequence can increase susceptibility to disease, or be the sign of a developing cancer. The challenge is detecting these alterations in DNA with affordable and easy to deploy technology. Today, medical labs can detect genomic alterations from patients' DNA samples, but it requires lengthy, expensive processing of DNA samples from a tissue biopsy or from blood.

Using standard silicon chip technology may enable the detection of these DNA alterations to be compact, more cost-effective and easier for mass production. IBM's goal is to integrate the fluidic chip with electronics that make it possible to transmit the data from the chip to datacenters for analysis. The long-term vision is that medical professionals could have a point-of-care device, packaged with the biochip, to conduct DNA testing that is then sent to the cloud for analysis. For example, the technology could be combined with cognitive tools such as Watson for Genomics or Watson Oncology to help detect the presence of DNA alterations, so doctors can propose treatment options tailored to their patients who have those mutations. As with all Watson technologies, the goal is to augment human intelligence. In this case, helping doctors make more informed decisions.

"Our goal is to help doctors realize the precision medicine paradigm through speeding up the analysis of DNA samples by generating more automated technology. To that end, we have developed research technology on a standard silicon chip, using standard CMOS wafer fabrication processes – to create our biochip," said Gustavo Stolovitzky, Program Director, IBM Translational Systems Biology and Nanobiotechnology, IBM Research.

"IBM Research has decades of investment in and deep expertise on semiconductor and fabrication technologies. We also have a unique infrastructure and skill sets to make devices with new functions, from manipulating lights to detecting molecules. This DNA biochip is one example of a successful demonstration of these capabilities and expertise at IBM Research in the era of Internet of Things (IoT)," said Qinghuang Lin, Program Manager, IBM IoT for Healthcare, IBM Research.

For more about the IBM Research technology, read the paper Wafer-Scale Integration of Sacrificial Nanofluidic Chips for Detecting and Manipulating Single DNA Molecules, published in Nature Communications' March 2016 issue.

  1. Hydrodynamics of diamond-shaped gradient nanopillar arrays for effective DNA translocation into nanochannelsACS Nano
  2. Liquid biopsy: monitoring cancer-genetics in the bloodNature Clinical Oncology

About IBM Research

For more than seven decades, IBM Research has defined the future of information technology with more than 3,000 researchers in 12 labs located across six continents. Scientists from IBM Research have produced six Nobel Laureates, 10 U.S. National Medals of Technology, five U.S. National Medals of Science, six Turing Awards, 19 inductees into the National Academy of Sciences and 20 inductees into the U.S. National Inventors Hall of Fame. For more information about IBM Research, visit www.ibm.com/research.

Contact Information

Chris Nay
IBM Media Relations – Research
1 (512) 286-7727
cnay@us.ibm.com

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/ibm-scientists-use-lab-on-a-chip-nanochannel-technology-designed-to-stretch-dna-to-help-detect-disease-300457852.html


'/>"/>
SOURCE IBM
Copyright©2017 PR Newswire.
All rights reserved


Related biology technology :

1. Research Team led by JCVI Scientists Uncover More Complexity and Detail in Southern African Genomic Diversity
2. NineSigma Announces Winners in $25,000 Sustainable Packaging Challenge in Conjunction With Scientists Without Borders and Partners
3. Highly lethal Ebola virus has diagnostic Achilles heel for biothreat detection, scientists say
4. A bright idea: Tiny injectable LEDs help neuroscientists study the brain
5. Scientists Find Way to Fast-Track Production of Stem Cells that Show Promise in Treating AMD
6. Scripps Research Institute Scientists Find Antibody that Transforms Bone Marrow Stem Cells Directly into Brain Cells
7. Scottish Scientists Lead This Years Life Science Discoveries
8. NYSCF scientists create personalized bone substitutes from skin cells
9. Biomarker could help scientists choose the right cell line when conducting stem cell experiments
10. Advancing Research to Therapies for Brain Tumors Conference Connects Academic Scientists to Industry Investors
11. Scientists to Meet with State and Federal Lawmakers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... 2017 , ... Vortex Biosciences , provider of circulating tumor cell (CTC) ... cells using Vortex microfluidic technology ” in Nature Precision Oncology on May 8th. ... Carlo and Dr. Matthew Rettig at the University of California, Los Angeles. The publication ...
(Date:5/23/2017)... Switzerland (PRWEB) , ... May 23, 2017 , ... ... forces machine manufacturers to re-engineer their control technology again and again. METTLER TOLEDO ... problem for machine manufacturers. The videos illustrate how integration of the ACT350 into ...
(Date:5/21/2017)... ... May 20, 2017 , ... ... the lengthy trial and error process by finding the right antidepressant faster. ... strengthen the doctor-patient relationship through a personalized approach to treatment. , ...
(Date:5/18/2017)... ... May 16, 2017 , ... Clinical Supplies Management (“CSM”), a Great Point Partners ... to grow. CSM has doubled in size over the past six months with ... strategy. , Roger Gasper joins CSM as Chief Financial Officer. Roger has over ...
Breaking Biology Technology:
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
(Date:4/3/2017)... 3, 2017  Data captured by IsoCode, ... detected a statistically significant association between the ... treatment and objective response of cancer patients ... predict whether cancer patients will respond to ... well as to improve both pre-infusion potency testing ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
Breaking Biology News(10 mins):