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Hypoxia Induces Stem Cell Gene Expression, Protein Production and Cell Surface Markers
Date:5/3/2010

ociated markers, such as Brachyury, Gata4, CCR4, LIN28 and Nodal FGF5 were also expressed at higher levels in the hypoxic cultures as compared to fibroblasts grown under normal oxygen levels.

These studies suggest hypoxic culture of somatic cells in large-scale bioreactor systems is a potentially feasible and efficient method for obtaining and producing adequate amounts of pluripotent stem cells and associated factors for clinical regenerative medicine applications.

"Reprogramming adult, differentiated somatic cell types through chemical manipulation or genetic transfection to transform the cells into a dedifferentiated, pluripotent stem cell phenotype has been the focus of many recent studies," said Dr. Jonathan Mansbridge, Chief Scientific Officer at Histogen. "Although these experiments have demonstrated the ability to induce cells back to a pluripotent state, the methods used have raised considerable issues regarding mutagenicity and clinical safety. We now have preliminary evidence that, by altering the oxygen levels under which neonatal fibroblasts are cultured, there is potential for a viable pluripotent stem cell source that would be free of these issues."

Human extracellular matrix (hECM) compositions produced under the hypoxia/microgravity conditions discussed here are covered by pending US patent #2010/0047305. "Induction of Stem Cell Marker Expression in Human Dermal Fibroblasts in Hypoxic Culture Conditions" will be presented by Dr. Mansbridge at the ICSCE event, taking place May 2-5, 2010 in Boston, Mass.

About Histogen
Histogen, launched in 2007, seeks to redefine regenerative medicine by developing a series of high value products that do not contain embryonic stem cells or animal components. Through Histogen's proprietary bioreactors that mimic the embryonic environment, newborn cells are encouraged to naturally produce the vital proteins and growth factors from which
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